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Villapún, et al.
                        A                                      B
















                        C                                      D















           Figure 6. Analysis of system optimization including (A) impact quantification of poor machine control, (B) method for input setting
           selection, (C) techniques used to monitor 3D printing, and (D) post processing steps used on the printed part.

           using an in-built system (40%), through system readings   and raw material [60,65] . Commercially  available  systems
           (40%) or other means. Only two medical experts report   have recently started to be available from companies such
           in situ process monitoring, with 42.9% using system   as Renishaw PLC, SLM Solutions GmbH or Velo 3D Inc.,
           readings, 14.3% depending on manual inspection and   however, most methods function in an open loop where
           the last neglecting parameter control. Other monitoring   information is processed and evaluated afterwards . An
                                                                                                         [65]
           tools included visual and manual inspection, experience   ideal in situ monitoring system should be able to detect
           or fundamental characterization of specifically designed   and  correct  any deviations  from  the  optimal  process
           specimens.                                          in a closed loop to prevent waste of time,  materials,
               All respondents, regardless of expertise, recognized   and energy due to failed production. Nevertheless, the
           the importance of parameter control to ensure the quality   datasets  involved  are  normally  too extensive  to enable
           of the finished part (Figure 6A). However, there seems to   real time processing, limiting AM uptake [60,65] . Thus, the
           be a clear disconnection between control and biological   limited presence of such systems in the surveyed firms
           compatibility. Manipulation  of these inputs is critical   seems reasonable, with greater uptake in manufacturing
           for part production and compliance with clinical needs;   and academia while of great interest for medical experts
           however, their selection seems to be commonly based on   (Figure 6C).
           the producer’s  recommendations, previous experience,   In the previous paragraphs, parameter optimization
           or simple parametric analysis (Figure 6B). In 2012, the   and monitoring was questioned; however, poor surface
           UK  AM special interest  group showcased the limited   finish, porosity, and heterogeneous microstructures of as
           robustness of available  systems, which  coupled  with   printed parts are still the main limitations of modern AM
           the reduced guidance on QC had caused reticence  and   processes. A  critical  example  of  their  influence  comes
           doubts on AM adoption [60,62,63] . More mature  processes   from the hand of fatigue performance, which even today
           have  well  established  practices with statistical  models   still challenges the use of metal AM parts. Anisotropic
           and controlled sampling, ensuring the viability of each   properties arising from microstructural orientation due to
           batch. In contrast, AM is an emerging technology focused   complex thermal history and the mesostructure naturally
           on personalization, which complicates implementation of   occurring from the layer-by-layer processing of the
           traditional QC processes [41,50,64] . As a response to this gap   base material weaken the dynamic resistance of as build
           in manufacturing control, in situ monitoring systems have   parts. Moreover, these  heavily synergize  with  defects
           been arising to control process deposition, energy source   in the form of unmelted particles and inner porosity to

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