Page 189 - IJB-9-1

International Journal of Bioprinting

REVIEW ARTICLE
State-of-the-art techniques for promoting tissue

regeneration: Combination of three-dimensional
bioprinting and carbon nanomaterials

Iruthayapandi Selestin Raja , Moon Sung Kang , Suck Won Hong , Hojae Bae ,
2
3
1†
2†
Bongju Kim , Yu-Shik Hwang , Jae Min Cha *, Dong-Wook Han *
5
4
6
1,2
1 BIO-IT Fusion Technology Research Institute, Pusan National University, Busan 46241, South
Korea
2 Department of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology,
Pusan National University, Busan 46241, South Korea
3
Department of Stem Cell and Regenerative Biotechnology, KU Convergence Science and
Technology Institute, Konkuk University, Seoul, 05029, Republic of Korea
4 Dental Life Science Research Institute/Innovation Research & Support Center for Dental Science,
Seoul National University Dental Hospital, Seoul 03080, South Korea
5 Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of
Dentistry, Kyung Hee University, Seoul 02447, South Korea
6 Department of Mechatronics Engineering, College of Engineering, Incheon National University,
Incheon 22012, South Korea
(This article belongs to the Special Issue: Functional Bioprinting Systems for Tissue Engineering)
† These authors contributed equally Abstract
to this work.
*Corresponding authors: Biofabrication approaches, such as three-dimensional (3D) bioprinting of hydrogels,
Jae Min Cha (j.cha@inu.ac.kr) have recently garnered increasing attention, especially in the construction of 3D
Dong-Wook Han (nanohan@pusan. structures that mimic the complexity of tissues and organs with the capacity for cy-
ac.kr)
tocompatibility and post-printing cellular development. However, some printed gels
Citation: Raja IS, Kang MS, show poor stability and maintain less shape fidelity if parameters such as polymer
Hong SW, et al., 2023, State-of-
the-art techniques for promoting nature, viscosity, shear-thinning behavior, and crosslinking are affected. Therefore,
tissue regeneration: Combination of researchers have incorporated various nanomaterials as bioactive fillers into poly-
three-dimensional bioprinting and meric hydrogels to address these limitations. Carbon-family nanomaterials (CFNs),
carbon nanomaterials. Int J Bioprint,
9(1): 635. hydroxyapatites, nanosilicates, and strontium carbonates have been incorporated
https://doi.org/10.18063/ijb.v9i1.635 into printed gels for application in various biomedical fields. In this review, follow-
ing the compilation of research publications on CFNs-containing printable gels in
Received: July 04, 2022
Accepted: August 23, 2022 various tissue engineering applications, we discuss the types of bioprinters, the pre-
Published Online: November 4, requisites of bioink and biomaterial ink, as well as the progress and challenges of
2022
CFNs-containing printable gels in this field.
Copyright: © 2022 Author(s).
This is an Open Access article
distributed under the terms of the Keywords: Carbon-family nanomaterial; Bioprinting; Tissue engineering; Bioink;
Creative Commons Attribution Biomaterial ink
License, permitting distribution
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: Whioce 1. Introduction
Publishing remains neutral with
regard to jurisdictional claims in Three-dimensional (3D) bioprinting, as a subset of additive manufacturing, has become
published maps and institutional an emerging technology in many biomedical applications, including tissue engineering
affiliations.

Volume 9 Issue 1 (2023) 181 https://doi.org/10.18063/ijb.v9i1.635