Page 205 - IJB-9-2

International Journal of Bioprinting

REVIEW ARTICLE
Toward better drug development:

Three-dimensional bioprinting in toxicological
research

4
1,3
Diána Szűcs 1,2,3 , Zsolt Fekete , Melinda Guba , Lajos Kemény 1,3,5 ,
Katalin Jemnitz , Emese Kis , Zoltán Veréb 1,3,6 *
4
4
1 Regenerative Medicine and Cellular Pharmacology Laboratory (HECRIN), Department of Dermatology
and Allergology, University of Szeged, Szeged, Hungary
2 Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary
3 Interdisciplinary Research Development and Innovation, Center of Excellence, University of Szeged,
Szeged, Hungary
4 Solvo Biotech, Szeged, Hungary
5 Hungarian Centre of Excellence for Molecular Medicine-University of Szeged Skin Research Group
(HCEMM-USZ Skin Research Group), University of Szeged, Szeged, Hungary
6 3D Center, University of Szeged, Szeged, Hungary
(This article belongs to the Special Issue: Novel culture techniques for 3D bioprinted tissue
surrogates to build patient-specific models)

Abstract

The importance of three-dimensional (3D) models in pharmacological tests and
personalized therapies is significant. These models allow us to gain insight into the cell
*Corresponding author:
Zoltán Veréb response during drug absorption, distribution, metabolism, and elimination in an organ-
(vereb.zoltan@med.u-szeged.hu) like system and are suitable for toxicological testing. In personalized and regenerative
medicine, the precise characterization of artificial tissues or drug metabolism processes
Citation: Szűcs D, Fekete Z,
Guba M, et al., 2023, Toward is more than crucial to gain the safest and the most effective treatment for the patients.
better drug development: Three- Using these 3D cell cultures derived directly from patient, such as spheroids, organoids,
dimensional bioprinting in and bioprinted structures, allows for testing drugs before administration to the patient.
toxicological research. Int J Bioprint,
9(2): 663. These methods allow us to select the most appropriate drug for the patient. Moreover,
https://doi.org/10.18063/ijb.v9i2.663 they provide chance for better recovery of patients, since time is not wasted during
Received: July 7, 2022 therapy switching. These models could be used in applied and basic research as
well, because their response to treatments is quite similar to that of the native tissue.
Accepted: October 01, 2022
Furthermore, they may replace animal models in the future because these methods
Published Online: January 6, 2023 are cheaper and can avoid interspecies differences. This review puts a spotlight on this
Copyright: © 2023 Author(s). dynamically evolving area and its application in toxicological testing.
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution Keywords: Liver; Drug development; Three-dimensional printing; ADME test; Organoid;
License, permitting distribution, Spheroid
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: Whioce
Publishing remains neutral with 1. Introduction
regard to jurisdictional claims in
published maps and institutional In drug development, the goal of a scientist is to develop a novel drug that alleviates
affiliations. a particular disease, thereby improving or even preventing a particular biological

Volume 9 Issue 2 (2023) 197 https://doi.org/10.18063/ijb.v9i2.663