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International Journal of Bioprinting            4D heterojunction shape reconfiguration by two-photon polymerization


               biomimetic features were realized or systematically   Author contributions
               integrated on-chip through our  method  with better
               chiral torsion, gripping, or smart photonics as   Conceptualization: Yufeng Tao
               demonstrated.                                   Investigation: Yufeng Tao, Zhiduo Xin, Xia Cao
            (iii) Furthermore, the satisfactory cytocompatibility and   Methodology: Chengchangfeng Lu
               cell-adhesive properties are ascribed to the hydrogel   Validation: Xuejiao Wang
               nature of the PEG and NIPAM in the composite    Writing – original draft: Yufeng Tao
               network. The measured cell viability and desirable   Writing – review & editing: Yunpeng Ren
               adhesion  behavior  proved MNIHs’ readiness     Ethics approval and consent to participate
               for the increasing market of bio-environmental
               applications.                                   Not applicable.
            (iv)  Experiments confirmed the molecule-level interaction   Consent for publication
               is  self-driven  without  any batteries, electric  motors,
               or  pneumatic  systems.  The  non-covalent  effect   All authors approved the final manuscript and the
               underneath interaction leads to a revolutionary μ/n   submission to this journal.
               scale transformation between mechanical energy and
               chemical energy.                                Availability of data
            (v)  Moreover, we unexpectedly found that the impaired   All data supporting this study are available in the
               MNIHs automatically recovered to initial shape   supplementary material of this article.
               like having self-consciousness without an in-built
               diagnosis or sensing parts, implying desirable device   References
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            previous dual/tri-layer design.
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            Acknowledgments                                    5.   Miao SD, Castro N, Nowicki M, et al., 2017, 4D printing
            All authors were grateful to Prof. Xiong Wei, Dr.  Deng   of  polymeric  materials  for  tissue  and  organ  regeneration.
            Cunsan, and Dr.  Fan Xuhao of Huazhong University of   Mater Today, 20: 577–591.
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            Funding                                            6.   Bastola A, Rodriguez NJ, Behl M, et al., 2021, Cactus-inspired
                                                                  design principles for soft robotics-based on 3D printed
            This research was financially supported by the National Key   hydrogel-elastomer systems. Mater Design, 202: 109515.
            R&D Program of China (SQ2018YFB110138), National      https://doi.org/10.1016/j.matdes.2021.109515
            Science Youth Fund of China (61805094), Natural Science
            Foundation of Jiangsu (BK20221363, BK20210746), and   7.   Almeida AC, Canejo J, Fernandes S, et al., 2018, Cellulose-
            China Postdoctoral Science Foundation (2017M622417).  based biomimetics and their applications.  Adv Mater,
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            Conflict of interest                                  https://doi.org/10.1002/adma.201703655
            The authors declare that they have no conflict of interest.  8.   Jeong HY, Lee E, An S, et al., 2020, 3D and 4D printing for


            Volume 9 Issue 3 (2023)                         22                         https://doi.org/10.18063/ijb.678
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