Page 348 - IJB-9-3

International Journal of Bioprinting

REVIEW ARTICLE
Mammalian-specific decellularized matrices

derived bioink for bioengineering of liver tissue
analogues: A review

Tanveer Ahmad Mir *, Makoto Nakamura , Shinji Sakai , Shintaroh Iwanaga ,
2
1
2
3
Shadil Ibrahim Wani , Alaa Alzhrani 1,4,8 , Kenichi Arai , Bilal Ahmed Mir ,
2
5
6
Shadab Kazmi , Abdullah M. Assiri , Dieter C. Broering 1,8
1,7
1,8
1 Transplant Research and Innovation Department, Tissue/Organ Bioengineering & BioMEMS
Laboratory, Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research
Centre, Riyadh 11211, KSA
2 Division of Biomedical System Engineering, Graduate School of Science and Engineering,
University of Toyama, Toyama 930-8555, Japan
3 Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School
of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan
4 Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz
University, Jeddah, KSA
5
Department of Clinical Biomaterial Applied Science, Faculty of Medicine, University of Toyama,
Toyama 930-0194, Japan
6 Division of Intellectual Information Engineering, Graduate School of Science and Engineering,
University of Toyama, Toyama 930-8555, Japan
7 Department of Child Health, School of Medicine, University of Missouri, Columbia, USA
8 College of Medicine, Alfaisal University, Riyadh 11211, KSA

*Corresponding author: Abstract
Tanveer Ahmad Mir
(tmir@kfshrc.edu.sa ) The absolute shortage of compatible liver donors and the growing number of potential
Citation: Mir TA, Nakamura M, recipients have led scientists to explore alternative approaches to providing tissue/
Sakai S, et al., 2023, Mammalian- organ substitutes from bioengineered sources. Bioartificial regeneration of a fully
specific decellularized matrices functional tissue/organ replacement is highly dependent on the right combination
derived bioink for bioengineering
of liver tissue analogues: A review. of engineering tools, biological principles, and materiobiology horizons. Over the
Int J Bioprint, 9(3): 714. past two decades, remarkable achievements have been made in hepatic tissue
https://doi.org/10.18063/ijb.714 engineering by converging various advanced interdisciplinary research approaches.
Received: December 05, 2022 Three-dimensional (3D) bioprinting has arisen as a promising state-of-the-art tool
Accepted: January 18, 2023 with strong potential to fabricate volumetric liver tissue/organ equivalents using
Published Online: March 20, 2023
viscosity- and degradation-controlled printable bioinks composed of hydrous
Copyright: © 2023 Author(s). microenvironments, and formulations containing living cells and associated
This is an Open Access article supplements. Source of origin, biophysiochemical, or thermomechanical properties
distributed under the terms of the
Creative Commons Attribution and crosslinking reaction kinetics are prerequisites for ideal bioink formulation and
License, permitting distribution realizing the bioprinting process. In this review, we delve into the forecast of the
and reproduction in any medium, potential future utility of bioprinting technology and the promise of tissue/organ-
provided the original work is
properly cited. specific decellularized biomaterials as bioink substrates. Afterward, we outline various
methods of decellularization, and the most relevant studies applying decellularized
Publisher’s Note: Whioce
Publishing remains neutral with bioinks toward the bioengineering of in vitro liver models. Finally, the challenges
regard to jurisdictional claims in and future prospects of decellularized material-based bioprinting in the direction of
published maps and institutional clinical regenerative medicine are presented to motivate further developments.
affiliations.

Volume 9 Issue 3 (2023) 340 https://doi.org/10.18063/ijb.714