Page 307 - IJB-9-4

International Journal of Bioprinting Design and biomechanical analysis of porous tantalum prostheses

in 2017. Follow-up observations of about 5 years indicate Methodology: Shilong Mao, Yang Liu, Fuyou Wang, Peng He
that the designed and fabricated prosthesis integrates well Supervision: Xianzhe Wu, Xingshuang Ma, Yanfeng Luo
with the surrounding bone tissue and the patient can Writing – original draft: Shilong Mao, Yang Liu
take normal movements without any discomfort (data Writing – review & editing: Shilong Mao, Xingshuang Ma,
not shown), supporting our numerical simulation results. Yanfeng Luo
Our attempts by combining patient-specific design and All authors read and approved the manuscript for
numerical simulation of the 3D-printed prostheses provide publication.
a valuable paradigm for prostheses design and may help to
improve the success rate of implants. However, it should Ethics approval and consent to participate
be noted that, bone tissues are anisotropic and their
mechanical properties are patient- and site-specific. Future Research ethics approval has been obtained from the
work should take bone tissues as anisotropic rather than ethics committee of the Southwest Hospital of Army
isotropic materials. In addition, a quantitative relationship Medical University, China for this study (2016-J-001), and
between the patient’s CT data and the bone mineral density informed consent has been obtained from the patient for
and bone mechanical properties should be established, participating in this study.
by which the patient- and site-specific bone remodeling
process followed by implantation of the prostheses could be Consent for publication
applied for FEA and biomechanical matching evaluation. The patient has consented to publish his relevant data in
this work.
5. Conclusion
In this work, we successfully constructed FEA models for Availability of data
the tibia and the patient-specific prosthesis based on the All data used in this work are presented in the paper.
patient’s CT data. By using the models, together with the
mechanical properties of 3D-printed porous tantalum References
and the patient’s weight and postures, the maximum von
Mises stress and displacement and compressive strain were 1. Woiczinski M, Steinbrück A, Weber P, et al., 2015,
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the biomechanical requirements for the prosthesis, the element model for total knee replacement. Comput Methods
porous tantalum prostheses with sufficient mechanical Biomech Biomed Eng, 19(10):1033–1045.
support to knee joint and matchable biomechanical https://doi.org/10.1080/10255842.2015.1089534
stimulation to tibia were successfully determined. This 2. Grelsamer RP, 2007, Applications of porous tantalum in total
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evaluating porous tantalum prostheses and may help to
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3. Matsuno H, Yokoyama A, Watari F, et al., 2001,
Acknowledgments Biocompatibility and osteogenesis of refractory metal
implants, titanium, hafnium, niobium, tantalum and
None. rhenium. Biomaterials, 22(11):1253–1262.

Funding https://doi.org/10.1016/S0142-9612(00)00275-1
4. Zou X, Li H, Bünger M, et al., 2004, Bone ingrowth
This study was funded by National Key Research and characteristics of porous tantalum and carbon fiber
Development Plan of China (2016YFB1101401) and interbody devices: An experimental study in pigs. Spine J,
National Natural Science Foundation of China (No. 4(1):99–105.
32271362).
https://doi.org/10.1016/S1529-9430(03)00407-8
Conflict of interest 5. Bobyn JD, Stackpool GJ, Hacking SA, et al., 1999,
Characteristics of bone ingrowth and interface mechanics
The authors declare no conflict of interest. of a new porous tantalum biomaterial. J Bone Joint Surg Br,
81(5):907–914.
Author contributions https://doi.org/10.1302/0301-620X.81B5.9283

Conceptualization: Xianzhe Wu, Xingshuang Ma, Yanfeng Luo 6. Rossi SMP, Perticarini L, Ghiara M, et al., 2022, High
Investigation: Shilong Mao, Yang Liu survival rate at mid-term follow up of porous tantalum

Volume 9 Issue 4 (2023) 299 https://doi.org/10.18063/ijb.735