Page 299 - IJB-9-5

International Journal of Bioprinting Blood components for tissue graft bioprinting

bioinks has been conducted in bone, cartilage, cardiac References
tissue, cornea, dermal, liver and pancreas, neural
tissues, and oral tissues. Solvent extrusion bioprinting 1. Groll J, Boland T, Blunk T, et al., 2016, Biofabrication:
technologies are likely to benefit from the incorporation Reappraising the definition of an evolving field.
of blood derivatives into bioinks. However, a deeper Biofabrication, 8(1): 013001.
understanding of the role of blood derivatives in https://doi.org/10.1088/1758-5090/8/1/013001
tissue repair and remodeling is needed to refine bioink 2. Mironov V, Trusk T, Kasyanov V, et al., 2009, Biofabrication:
formulations in ways that reproduce the complex biology A 21st century manufacturing paradigm. Biofabrication, 1:
and functionality of host tissues. 022001.
To fulfill as many requirements as possible with https://doi.org/10.1088/1758-5082/1/2/022001
good predictability, biomaterials can be functionalized 3. Zhang B, Cristescu R, Chrisey DB, et al., 2020, Solvent-
with tailored blood-derived products, resulting in based extrusion 3D printing for the fabrication of tissue
the transformation of inert biomaterials into reactive engineering scaffolds. Int J Bioprint, 6: 28–42.
(stimuli-response) biomaterials, inspired by physiological
repair mechanisms in which hemostasis (blood clot https://doi.org/10.18063/IJB.V6I1.211
formation, fibrin formation) is the starting point, and 4. De¸bski T, Kurzyk A, Ostrowska B, et al., 2020, Scaffold
platelet degranulation and secretome release trigger the vascularization method using an adipose-derived stem cell
regenerative cascade. (ASC)-seeded scaffold prefabricated with a flow-through
pedicle. Stem Cell Res Ther, 11: 1–14.
Acknowledgments https://doi.org/10.1186/S13287-019-1535-Z/FIGURES/7

None. 5. Lee J, Park D, Seo Y, et al., 2020, Organ-level functional 3D
tissue constructs with complex compartments and their
Funding preclinical applications. Adv Mater, 32: 2002096.
This work was supported by a collaborative fundamental https://doi.org/10.1002/ADMA.202002096
research grant from the Basque Government Elkartek 6. Deo KA, Singh KA, Peak CW, et al., 2020, Bioprinting
program under grant no. BIO4CURE KK-2022-00019/ 101: Design, fabrication, and evaluation of cell-laden 3D
BCB/01. The authors thank the funding from Institute bioprinted scaffolds. Tissue Eng - Part A, 26: 318–338.
of Health Carlos III (ISCIII) through the Biobanks and https://doi.org/10.1089/TEN.TEA.2019.0298/ASSET/
Biomodels Platform (PT20/00185). IMAGES/LARGE/TEN.TEA.2019.0298_FIGURE6.JPEG
Conflict of interest 7. Supernat A, Popęda M, Pastuszak K, et al., 2021,
Transcriptomic landscape of blood platelets in healthy
The authors declare no conflict of interest. donors. Sci Rep, 11: 15679.
https://doi.org/10.1038/s41598-021-94003-z
Author contributions
8. Nieto D, Jiménez G, Moroni L, et al., 2022, Biofabrication
Conceptualization: Cristina Del Amo, Isabel Andia approaches and regulatory framework of metastatic tumor‐
Funding acquisition: Isabel Andia on‐a‐chip models for precision oncology. Med Res Rev, 42:
Writing – original draft: Cristina Del Amo, Isabel Andia 1978–2001
Writing – review & editing: Cristina Del Amo, Isabel Andia https://doi.org/10.1002/MED.21914

Ethics approval and consent to participate 9. Burdis R, Chariyev-Prinz F, Browe DC, et al., 2022,
Spatial patterning of phenotypically distinct microtissues
Not applicable. to engineer osteochondral grafts for biological joint
resurfacing. Biomaterials, 289: 121750.
Consent for publication https://doi.org/10.1016/J.BIOMATERIALS.2022.121750

Not applicable. 10. Zhang Q, Nguyen PD, Shi S, et al., 2018, 3D bio-printed
scaffold-free nerve constructs with human gingiva-
Availability of data derived mesenchymal stem cells promote rat facial nerve
Not applicable. regeneration. Sci Rep, 8: 1–11.
https://doi.org/10.1038/s41598-018-24888-w

Volume 9 Issue 5 (2023) 291 https://doi.org/10.18063/ijb.762