Page 230 - IJB-9-6

International

Journal of Bioprinting

REVIEW ARTICLE
Bioprinting technology for the management

of diabetic foot disease: Emerging applications,
challenges, and prospects

Fan Xu , Shunli Rui , Cheng Yang , Xiaoyan Jiang , Wei Wu , Xianlun Tang ,
1
1
1
2
3
1
David G. Armstrong , Yu Ma *, and Wuquan Deng *
1
1
4
1 Department of Endocrinology, School of Medicine, Chongqing Emergency Medical Center,
Chongqing University Central Hospital, Chongqing 400014, China
2 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and
Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing
University, Chongqing 400030, China
3 Chongqing Key Laboratory of Complex Systems and Bionic Control, College of Automation,
Chongqing University of Posts and Telecommunications, Nan’an district, Chongqing 400065, China
4 Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles,
CA 90033, USA
(This article belongs to the Special Issue: Bioprinting strategies for managing skin diseases and injuries)
Abstract
Most conventional therapies have limitations in the repair of complex wounds caused
by chronic inflammation in patients with diabetic foot ulcers (DFUs). In response to
the demand for more biotechnology strategies, bioprinting has been explored in
the regeneration field in recent years. However, challenges remain regarding the
*Corresponding authors: structure of complex models and the selection of proper biomaterials. The purpose
Yu Ma (81846846@qq.com) of this review is to introduce the current applications of bioprinting technology
Wuquan Deng in chronic diabetic foot wound healing. First, the most common application of
(wuquandeng@cqu.edu.cn)
bioprinting in producing skin equivalents to promote wound healing is introduced;
Citation: Xu F, Rui S, Yang C, et al., second, functional improvements in the treatment of chronic and difficult-to-
2023, Bioprinting technology for
the management of diabetic foot heal DFU wounds facilitated by bioprinting applications are discussed; and last
disease: Emerging applications, but not least, bioprinting applications in addressing unique diabetic foot disease
challenges, and prospects. Int J characteristics are summarized. Furthermore, the present work summarizes material
Bioprint, 9(6): 0142.
https://doi.org/10.36922/ijb.0142 selection and correlations between three-dimensional (3D) bioprinting and a variety
of biomimetic strategies for accelerating wound healing. Novel, biotechnological
Received: April 17, 2023 tools such as organoids for developing new biomaterials for bioprinting in the future
Accepted: June 12, 2023
Published Online: July 31, 2023 are also discussed.
Copyright: © 2023 Author(s).
This is an Open Access article Keywords: Bioprinting; Wound; Skin; Diabetic foot disease; Biomaterial
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited. 1. Introduction
Publisher’s Note: AccScience Bioprinting is an emerging technology with widespread applications in regenerative
Publishing remains neutral with medicine . In recent years, various types of scaffold materials and biomaterial inks
[1]
regard to jurisdictional claims in have been developed for biomedical applications . Currently, bioprinting is used
[2]
published maps and institutional
affiliations. not only for implants and treatment in vivo but also for model construction and

Volume 9 Issue 6 (2023) 222 https://doi.org/10.36922/ijb.0142