Page 366 - IJB-9-6

International Journal of Bioprinting Surface modification of PCL scaffolds

roughness of PCL scaffolds, making them favorable for cell 2. Stahl A, Yang YP, 2021, Regenerative approaches for the
proliferation and adhesion. Additionally, osteoinductive treatment of large bone defects. Tissue Eng Part B Rev, 27(6):
properties were enhanced in vitro and in vivo, likely due 539–547.
to modified surface-mediated enhancement of osteogenic https://doi.org/10.1089/ten.TEB.2020.0281
differentiation via the integrinα2/β1-PI3K-Akt signaling 3. Dimitriou R, Jones E, Mcgonagle D, et al., 2011, Bone
pathway. These findings suggest that NaOH treatment is a regeneration: Current concepts and future directions. BMC
cost-efficient and effective strategy for surface modification Med, 9: 66.
of PCL scaffolds in bone tissue regeneration.
https://doi.org/10.1186/1741-7015-9-66.
Acknowledgments 4. Azi ML, Aprato A, Santi I, et al., 2016, Autologous bone
graft in the treatment of post-traumatic bone defects: A
We acknowledge Mrs. Xiaoli Qu for helping the team use systematic review and meta-analysis. BMC Musculoskelet
immunofluorescence microscopy (State Key Laboratory Disord, 17(1): 465.
for Manufacturing Systems Engineering, Xi’an Jiaotong
University). The Figdraw was acknowledged for producing https://doi.org/10.1186/s12891-016-1312-4
Scheme 1 and Figure 6F. 5. Charbe NB, Tambuwala M, Palakurthi SS, et al., 2023,
Biomedical applications of three-dimensional bioprinted
Funding craniofacial tissue engineering. Bioeng Transl Med, 8(1):
e10333.
This work was supported by National Natural Science
Foundation of China (No. 31971272) and International https://doi.org/10.1002/btm2.10333
Science and Technology Cooperation Keg Program project 6. Shi Y, Yu L, Gong C, et al., 2021, A bioactive magnesium
of Shaanxi Province (No. 2023-GHZD-25). phosphate cement incorporating chondroitin sulfate for
bone regeneration. Biomed Mater, 16(3).
Conflict of interest https://doi.org/10.1088/1748-605X/abf5c4
The authors declare no conflicts of interests. 7. Roseti L, Parisi V, Petretta M, et al., 2017 Scaffolds for bone
tissue engineering: State of the art and new perspectives.
Author contributions Mater Sci Eng C Mater Biol Appl, 78: 1246–1262.
Conceptualization: Hongbin Fan https://doi.org/10.1016/j.msec.2017.05.017
Formal analysis: Jingyi Dang, Zhao Zhang 8. Wunner FM, Wille ML, Noonan TG, et al., 2018, Melt
Methodology: Yubo Shi, Lei Wang electrospinning writing of highly ordered large volume
Resources: Jiankang He, Zhennan Qiu, Xiaoli, Qu scaffold architectures. Adv Mater, 30(20): e1706570.
Writing – original draft: Yubo Shi, Liguo Sun https://doi.org/10.1002/adma.201706570
Writing – review & editing: Yubo Shi, Hongbin Fan
9. Kade JC, Dalton PD, 2021, Polymers for melt electrowriting.
Ethics approval and consent to participate Adv Healthc Mater, 10(1): e2001232.
https://doi.org/10.1002/adhm.202001232
The animal study was approved by Ethics Committees of The
Fourth Military Medical University (IACUC-20220071). 10. Chen Z, Liu Y, Huang J, et al., 2022, Influences of process
parameters of near-field direct-writing melt electrospinning
Consent for publication on performances of polycaprolactone/nano-hydroxyapatite
scaffolds. Polymers (Basel), 14(16): 3404.
Not applicable.
https://doi.org/10.3390/polym14163404
Availability of data 11. He J, Zhang B, Li Z, et al., 2020, High-resolution
electrohydrodynamic bioprinting: A new biofabrication
The request for raw data can be directed to the strategy for biomimetic micro/nanoscale architectures and
corresponding author. living tissue constructs. Biofabrication, 12(4): 042002.

References https://doi.org/10.1088/1758-5090/aba1fa
12. Mirzaei M, Dodi G, Gardikiotis I, et al., 2023, 3D high-
1. Maruyama T, Stevens R, Boka A, et al., 2021, BMPR1A maintains precision melt electro written polycaprolactone modified
skeletal stem cell properties in craniofacial development and with yeast derived peptides for wound healing. Biomater
craniosynostosis. Sci Transl Med, 13(583): eabb4416. Adv, 149: 213361.
https://doi.org/10.1126/scitranslmed.abb4416 https://doi.org/10.1016/j.bioadv.2023.213361

Volume 9 Issue 6 (2023) 358 https://doi.org/10.36922/ijb.1071