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Innovative Medicines & Omics Antioxidant nanomedicines for therapies

acid and edetate calcium disodium were used in clinic for while CeO nanoparticles catalyze antioxidation reactions
2
eliminating Pb ions, but suffer from low selectivity and side to alleviate oxidative damage, synergistically elevating the
effects. Natural bacteria have presented high performances therapeutic efficacy of Pb poisoning.
498
in adsorption of heavy metal, and Pan et al. further
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constructed a bacteria-based bioreactor for concurrent Although the applications of antioxidant nanomedicines
500
Pb ion adsorption and ROS scavenging (Figure 40). The for the treatment of these diseases are in their early stage
bioreactor was fabricated by decorating CeO nanoparticles (Table 10), it is expected that more advances will be made
2
on a nonpathogenic bacteria Escherichia coli MG1655, in the future by constructing new versatile antioxidant
which can accumulate in Pb-rich organs to absorb Pb ions, nanomedicines.

Table 10. Summary of representative antioxidant nanomedicines for the treatment of other diseases
Antioxidant nanomedicine Reaction type Disease References
Zr-doped CeO nanoparticle Catalytic Sepsis 452
2
Single-atom Co nanocatalyst Catalytic Sepsis 454
WS nanosheet Catalytic Sepsis 455
2
Mn O nanoparticle Catalytic Spinal cord injury 460
3 4
MnO nanoparticle embedded in a hydrogel Catalytic Spinal cord injury 463
2
CeO nanoparticle in a nanofiber bundle scaffold Catalytic Tendon injury 466
2
Polydopamine nanoparticle Non-catalytic Periodontal disease 46
Epigallocatechin gallate-based nanoparticle Non-catalytic Periodontal disease 469
CeO nanoparticle in orofacial prosthesis Catalytic Nasopalatal defect 472
2
CeO nanoparticle with bovine serum albumin Catalytic Depression 478
2
Bilirubin nanomedicine Non-catalytic Acute pancreatitis 484
Prussian blue nanoparticle Catalytic Acute pancreatitis 485
Nb C nanosheet Non-catalytic Ionizing irradiation injury 489
2
Melanin nanoparticle Noncatalytic Ionizing irradiation injury 490
Prussian blue nanoparticle Catalytic Ionizing irradiation injury 491
CeO nanoparticle Catalytic Ionizing irradiation injury 492
2
Mn O /CeO nanoparticle Catalytic Ionizing irradiation injury 493
3 4 2
CeO nanoparticle on Escherichia coli MG1655 Catalytic Heavy metal poisoning 500
2

Figure 40. Schematic illustration of heavy metal poisoning protection using a bacteria-based bioreactor. Reproduced with permission from Pan et al.
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Copyright © 2019, Wiley-VCH.

Volume 1 Issue 1 (2024) 45 doi: 10.36922/imo.2527