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INNOSC Theranostics and
            Pharmacological Sciences                                            Repurposed Drugs as inhibitors of Pfmrk



              In conclusion, our work underlines the significance   cycle control and transcription. J Cell Sci, 118: 5171–5180.
            of targeting Pfmrk as a potential antimalarial strategy.      https://doi.org/10.1242/jcs.02718
            These findings lay a promising foundation for further
            experimental validation and the development of novel   5.   Keenan SM, Geyer JA, Welsh WJ,  et al., 2005, Rational
            antimalarial drugs.                                   inhibitor design and iterative screening in the identification
                                                                  of selective plasmodial cyclin-dependent kinase inhibitors.
            Acknowledgments                                       Comb Chem High Throughput Screen, 8: 27–38.
                                                                  https://doi.org/10.2174/1386207053328183
            The  infrastructure support, the  resources  and guidance
            provided by IIT BHU and PARAM Shivay Facility under   6.   Li Z, Le RK, Geyer JA,  et al., 2001, Influence of human
            the National Supercomputing Mission, Government of    p16INK4 and p21CIP1 on the in vitro activity of recombinant
            India at the Indian Institute of Technology BHU, Varanasi   Plasmodium  falciparum cyclin-dependent protein kinases.
            are gratefully acknowledged.                          Biochem Biophys Res Commun, 288: 1207–1211.
                                                                  https://doi.org/10.1006/bbrc.2001.5920
            Funding                                            7.   Ko J, Park H, Heo L, et al., 2012, Galaxy WEB server for
            The research supported by research fellowship granted by   protein structure prediction and refinement. Nucleic Acids
            the Indian Institute of Technology (BHU).             Res, 40: W294–W297.
                                                                  https://doi.org/10.1093/nar/gks493
            Conflict of interest
                                                               8.   Laskowski RA, MacArthur MW, Moss DS,  et al.,  1993,
            The authors declare no conflicts of interest.         PROCHECK:  A  program  to check the  stereochemical
                                                                  quality of protein structures. J Appl Crystallogr, 26: 283–291.
            Author contributions
                                                                  https://doi.org/10.1107/s0021889892009944
            Conceptualization: Abhishek Sahu                   9.   Guex N, Peitsch MC, 1997, SWISS-MODEL and the Swiss-
            Formal analysis: Abhishek Sahu, Debanjan Kundu        PdbViewer: An environment for comparative protein
            Investigation: Abhishek Sahu, Tanuj Handa             modeling. Electrophoresis, 18: 2714–2723.
            Methodology: All authors
            Writing – original draft: Abhishek Sahu, Debanjan Kundu     https://doi.org/10.1002/elps.1150181505
            Writing – review & editing: All authors            10.  Waters PJ, Parniak MA, Akerman BR,  et al., 2000,
                                                                  Characterization of phenylketonuria missense substitutions,
            Ethics approval and consent to participate            distant from the phenylalanine hydroxylase active site,
                                                                  illustrates a paradigm for mechanism and potential
            Not applicable.                                       modulation of phenotype. Mol Genet Metab, 69: 101–110.

            Consent for publication                               https://doi.org/10.1006/mgme.2000.2965
            Not applicable.                                    11.  Lagorce D, Sperandio O, Galons H, et al., 2008, FAF-Drugs2:
                                                                  Free ADME/tox filtering tool for drug discovery and
            Availability of data                                  chemical biology projects. BMC Bioinform, 9: 396.
            Data can be requested from corresponding author       https://doi.org/10.1186/1471-2105-9-396
            following formal request.                          12.  Dallakyan S, Olson AJ, 2015, Small molecule  library
                                                                  screening by docking with PyRx.  Methods Mol Biol,
            References                                            1263: 243–250.

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            Volume 7 Issue 1 (2024)                         9                         https://doi.org/10.36922/itps.1313
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