Page 50 - ITPS-7-2

INNOSC Theranostics

and Pharmacological Sciences

REVIEW ARTICLE
Navigating the complex landscape of cardiac

metabolism in health and disease states

Pongpan Tanajak * and Tipthida Pasachan 3
1,2
1 Rehabilitation Center, Apinop Wetchakam Hospital, Kaeng Khoi, Saraburi, Thailand
2 Nakorn-Nan Physical Therapy Clinic, Rehabilitation Center, Pupiang, Nan, Thailand
3 Department of Health and Aesthetics, Faculty of Integrative Medicine, Rajamangala University of
Technology Thanyaburi, Khlong Luang, Pathum Thani, Thailand

Abstract

The intricate interplay between cardiovascular health and metabolic regulation forms
a critical junction in understanding the complexities of heart-related conditions.
Cardiometabolic regulation orchestrates a sophisticated network of factors governing
energy utilization, substrate metabolism, and cellular processes within the cardiovascular
system. Balancing these mechanisms is pivotal for optimal heart function, considering
the substantial energy demands for both contractile and non-contractile activities. In a
healthy heart, fatty acids (FAs) derived from FA β-oxidation contribute to approximately
70% of total energy production. However, emerging evidence sheds light on pathological
changes in the heart that lead to profound metabolic alterations. These alterations involve
*Corresponding author: a shift from predominant FA utilization to alternative substrates such as glucose and
Pongpan Tanajak ketone bodies, accompanied by an increased reliance on FAs. This metabolic remodeling
(ptanajak2531@gmail.com) extends beyond substrate metabolism, encompassing changes in transporter
Citation: Tanajak P, Pasachan T. expression, the activity of metabolic-related proteins, hormonal functions, and cardiac
Navigating the complex landscape mitochondrial energetics. This comprehensive review article delves into the intricate web
of cardiac metabolism in health of cardiometabolic regulation, elucidating the multifaceted factors influencing cardiac
and disease states. INNOSC
Theranostics and Pharmacological metabolism across diverse states encompassing health, metabolic disorders, and heart
Sciences. INNOSC Theranostics diseases. Unraveling the molecular intricacies and interconnected pathways shaping
and Pharmacological Sciences. cardiac metabolism in various physiological and pathological conditions provides
2024;7(2):2302.
doi: 10.36922/itps.2302 critical insights into the adaptive mechanisms and dysregulations associated with heart-
related conditions. Furthermore, the exploration of these regulatory mechanisms offers
Received: November 23, 2023
promising avenues for targeted therapeutic interventions and diagnostic strategies
Accepted: January 12, 2024 in cardiovascular medicine. Integrating multidisciplinary approaches and leveraging
Published Online: November 23, advanced technologies will facilitate a deeper understanding of cardiac metabolism,
2023 paving the way for innovative interventions to mitigate metabolic dysregulation and
Copyright: © 2024 Author(s). optimize cardiac health.
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution Keywords: Cardiac metabolism; Obesity; Metabolic syndrome; Diabetes mellitus;
License, permitting distribution, Myocardial ischemia; Cardiac hypertrophy; Heart failure
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with 1. Introduction
regard to jurisdictional claims in
published maps and institutional Mitochondrial fatty acid (FA) utilization, glycolysis, and glucose oxidation are pivotal
affiliations processes responsible for generating almost all of the total adenosine triphosphate

Volume 7 Issue 2 (2024) 1 doi: 10.36922/itps.2302