Page 19 - ITPS-8-2
P. 19
INNOSC Theranostics and
Pharmacological Sciences AMPK in metabolism, energy and aging
Pharmacol. 2021;12:753881. activates AMPK-Nrf2 signaling to protect neuronal cells
from oxygen glucose deprivation-reoxygenation. Aging
doi: 10.3389/fphar.2021.753881
(Albany NY). 2019;11:12032-12042.
62. Wang Y, Li X, Guo Y, Chan L, Guan X. alpha-Lipoic acid doi: 10.18632/aging.102534
increases energy expenditure by enhancing adenosine
monophosphate-activated protein kinase-peroxisome 72. Jensen TE, Ross FA, Kleinert M, et al. PT-1 selectively
proliferator-activated receptor-gamma coactivator-1alpha activates AMPK-γ1 complexes in mouse skeletal muscle,
signaling in the skeletal muscle of aged mice. Metabolism. but activates all three γ subunit complexes in cultured
2010;59:967-976. human cells by inhibiting the respiratory chain. Biochem J.
2015;467:461-472.
doi: 10.1016/j.metabol.2009.10.018
doi: 10.1042/BJ20141142
63. Dean S, Braakhuis A, Paton C. The effects of EGCG on fat
oxidation and endurance performance in male cyclists. Int J 73. Zadra G, Photopoulos C, Tyekucheva S, et al. A novel direct
Sport Nutr Exerc Metab. 2009;19:624-644. activator of AMPK inhibits prostate cancer growth by
blocking lipogenesis. EMBO Mol Med. 2014;6:519-538.
doi: 10.1123/ijsnem.19.6.624
doi: 10.1002/emmm.201302734
64. Chen W, Pan Y, Wang S, et al. Cryptotanshinone activates
AMPK-TSC2 axis leading to inhibition of mTORC1 74. Kudryavtseva AV, Krasnov GS, Dmitriev AA, et al.
signaling in cancer cells. BMC Cancer. 2017;17:34. Mitochondrial dysfunction and oxidative stress in aging and
cancer. Oncotarget. 2016;7:44879-44905.
doi: 10.1186/s12885-016-3038-y
doi: 10.18632/oncotarget.9821
65. Luo Z, Ma L, Zhao Z, et al. TRPV1 activation improves
exercise endurance and energy metabolism through 75. Vatner SF, Zhang J, Oydanich M, Berkman T, Naftalovich R,
PGC-1α upregulation in mice. Cell Res. 2012;22:551-564. Vatner DE. Healthful aging mediated by inhibition of
oxidative stress. Ageing Res Rev. 2020;64:101194.
doi: 10.1038/cr.2011.205
doi: 10.1016/j.arr.2020.101194
66. Wu RM, Sun YY, Zhou TT, et al. Arctigenin enhances
swimming endurance of sedentary rats partially by 76. Hajam YA, Rani R, Ganie SY, et al. Oxidative stress in
regulation of antioxidant pathways. Acta Pharmacol Sin. human pathology and aging: Molecular mechanisms and
2014;35:1274-1284. perspectives. Cells. 2022;11:552.
doi: 10.1038/aps.2014.70 doi: 10.3390/cells11030552
67. Jeong HW, Cho SY, Kim S, et al. Chitooligosaccharide 77. Covarrubias AJ, Kale A, Perrone R, et al. Senescent cells
+
induces mitochondrial biogenesis and increases exercise promote tissue NAD decline during ageing via the activation
+
endurance through the activation of Sirt1 and AMPK in of CD38 macrophages. Nat Metab. 2020;2:1265-1283.
rats. PLoS One. 2012;7(7):e40073. doi: 10.1038/s42255-020-00305-3
doi: 10.1371/journal.pone.0040073 78. de Lange P, Lombardi A, Silvestri E, et al. Physiological
68. Murase T, Misawa K, Haramizu S, Minegishi Y, Hase T. approaches targeting cellular and mitochondrial pathways
Nootkatone, a characteristic constituent of grapefruit, underlying adipose organ senescence. Int J Mol Sci.
stimulates energy metabolism and prevents diet-induced 2023;24:11676.
obesity by activating AMPK. Am J Physiol Endocrinol Metab. doi: 10.3390/ijms241411676
2010;299:E266-E275.
79. Cavaliere G, Catapano A, Trinchese G, et al. Crosstalk
doi: 10.1152/ajpendo.00774.2009 between adipose tissue and hepatic mitochondria in the
69. Baltgalvis KA, White K, Li W, et al. Exercise performance development of the inflammation and liver injury during
and peripheral vascular insufficiency improve with AMPK ageing in high-fat diet fed rats. Int J Mol Sci. 2023;24:2967.
activation in high-fat diet-fed mice. Am J Physiol Heart Circ doi: 10.3390/ijms24032967
Physiol. 2014;306:H1128-H1145.
80. Weir HJ, Yao P, Huynh FK, et al. Dietary restriction and
doi: 10.1152/ajpheart.00839.2013 AMPK increase lifespan via mitochondrial network and
70. Xu YY, Chen FL, Ji F, Fei HD, Xie Y, Wang SG. Activation peroxisome remodeling. Cell Metab. 2017;26:884-896.e5.
of AMP-activated protein kinase by compound 991 protects doi: 10.1016/j.cmet.2017.09.024
osteoblasts from dexamethasone. Biochem Biophys Res 81. Bonda DJ, Lee HG, Camins A, et al. The sirtuin pathway in
Commun. 2018;495:1014-1021.
ageing and Alzheimer disease: Mechanistic and therapeutic
doi: 10.1016/j.bbrc.2017.11.132 considerations. Lancet Neurol. 2011;10:275-579.
71. Mo Y, Zhu JL, Jiang A, Zhao J, Ye L, Han B. Compound 13 doi: 10.1016/S1474-4422(11)70013-8
Volume 8 Issue 2 (2025) 13 doi: 10.36922/itps.4852

