Page 17 - ITPS-8-2
P. 17
INNOSC Theranostics and
Pharmacological Sciences AMPK in metabolism, energy and aging
and peroxisome proliferator-activated receptor-γ doi: 10.1016/j.cmet.2009.03.012
coactivator-1α (PGC-1α) deacetylation by physical activity: 27. Foretz M, Even PC, Viollet B. AMPK activation reduces
Intact adipocytokine signaling is required. Diabetes. hepatic lipid content by increasing fat oxidation in vivo. Int J
2011;60:157-167. Mol Sci. 2018;19:2826.
doi: 10.2337/db10-0331 doi: 10.3390/ijms19092826
17. Zhou G, Myers R, Li Y, et al. Role of AMP-activated protein 28. Herzig S, Shaw RJ. AMPK: Guardian of metabolism
kinase in mechanism of metformin action. J Clin Invest. and mitochondrial homeostasis. Nat Rev Mol Cell Biol.
2001;108:1167-1174. 2018;19:121-135.
doi: 10.1172/JCI13505 doi: 10.1038/nrm.2017.95
18. Hawley SA, Ford RJ, Smith BK, et al. The Na+/glucose 29. Rehman G, Shehzad A, Khan AL, Hamayun M. Role of
cotransporter inhibitor canagliflozin activates AMPK by AMP-activated protein kinase in cancer therapy. Arch
inhibiting mitochondrial function and increasing cellular Pharm (Weinheim). 2014;347:457-468.
AMP levels. Diabetes. 2016;65:2784-2794.
doi: 10.1002/ardp.201300402
doi: 10.2337/db16-0058
30. Alessi DR, Sakamoto K, Bayascas JR. LKB1-dependent
19. O’Brien AJ, Villani LA, Broadfield LA, et al. Salicylate activates signaling pathways. Annu Rev Biochem. 2006;75:137-163.
AMPK and synergizes with metformin to reduce the survival
of prostate and lung cancer cells ex vivo through inhibition of doi: 10.1146/annurev.biochem.75.103004.142702
de novo lipogenesis. Biochem J. 2015;469:177-187. 31. Egan DF, Shackelford DB, Mihaylova MM, et al.
doi: 10.1042/BJ20150122 Phosphorylation of ULK1 (hATG1) by AMP-activated
protein kinase connects energy sensing to mitophagy.
20. Yun H, Ha J. AMP-activated protein kinase modulators: Science. 2011;331:456-461.
A patent review (2006-2010). Expert Opin Ther Pat.
2011;21:983-1005. doi: 10.1126/science.1196371
doi: 10.1517/13543776.2011.577069 32. Kim J, Kim YC, Fang C, et al. Differential regulation of
distinct Vps34 complexes by AMPK in nutrient stress and
21. Madiraju AK, Erion DM, Rahimi Y, et al. Metformin autophagy. Cell. 2013;152:290-303.
suppresses gluconeogenesis by inhibiting mitochondrial
glycerophosphate dehydrogenase. Nature. 2014;510:542-546. doi: 10.1016/j.cell.2012.12.016
doi: 10.1038/nature13270 33. Jansen T, Kvandová M, Daiber A, et al. The AMP-activated
protein kinase plays a role in antioxidant defense and
22. Ruderman NB, Keller C, Richard AM, et al. Interleukin-6 regulation of vascular inflammation. Antioxidants (Basel).
regulation of AMP-activated protein kinase. Potential role 2020;9:525.
in the systemic response to exercise and prevention of the
metabolic syndrome. Diabetes. 2006;55:S48-S54. doi: 10.3390/antiox9060525
doi: 10.2337/db06-s007 34. Mounier R, Théret M, Lantier L, Foretz M, Viollet B.
Expanding roles for AMPK in skeletal muscle plasticity.
23. Grahame Hardie D. Regulation of AMP-activated protein Trends Endocrinol Metab. 2015;26:275-286.
kinase by natural and synthetic activators. Acta Pharm Sin
B. 2016;6:1-19. doi: 10.1016/j.tem.2015.02.009
35. Hall DT, Griss T, Ma JF, et al. The AMPK agonist
doi: 10.1016/j.apsb.2015.06.002
5-aminoimidazole-4-carboxamide ribonucleotide (AICAR),
24. Lee JM, Seo WY, Song KH, et al. AMPK-dependent but not metformin, prevents inflammation-associated
repression of hepatic gluconeogenesis via disruption of cachectic muscle wasting. EMBO Mol Med. 2018;10:e8307.
CREB.CRTC2 complex by orphan nuclear receptor small
heterodimer partner. J Biol Chem. 2010;285:32182-32191. doi: 10.15252/emmm.201708307
doi: 10.1074/jbc.M110.134890 36. Sartori R, Romanello V, Sandri M. Mechanisms of muscle
atrophy and hypertrophy: Implications in health and
25. Guttzeit S, Backs J. Post-translational modifications talk and disease. Nat Commun. 2021;12:330.
crosstalk to class IIa histone deacetylases. J Mol Cell Cardiol.
2022;162:53-61. doi: 10.1038/s41467-020-20123-1
37. Shang R, Miao J. Mechanisms and effects of metformin on
doi: 10.1016/j.yjmcc.2021.08.007
skeletal muscle disorders. Front Neurol. 2023;14:1275266.
26. Zhang BB, Zhou G, Li C. AMPK: An emerging drug target
for diabetes and the metabolic syndrome. Cell Metab. doi: 10.3389/fneur.2023.1275266
2009;9:407-416. 38. Neufer PD, Bamman MM, Muoio DM, et al. Understanding
Volume 8 Issue 2 (2025) 11 doi: 10.36922/itps.4852