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INNOSC Theranostics and
            Pharmacological Sciences                                             AMPK in metabolism, energy and aging



               the cellular and molecular mechanisms of physical activity-  50.  Möller I, Wintermeyer A, Bender K, et al. Screening for the
               induced health benefits. Cell Metab. 2015;22:4-11.  synthetic cannabinoid JWH-018 and its major metabolites
                                                                  in human doping controls. Drug Test Anal. 2011;3:609-620.
               doi: 10.1016/j.cmet.2015.05.011
            39.  Fan W, Evans RM. Exercise mimetics: Impact on health and      doi: 10.1002/dta.158
               performance. Cell Metab. 2017;25:242-247.       51.  Regensteiner JG,  Bauer  TA,  Reusch  JE. Rosiglitazone
               doi: 10.1016/j.cmet.2016.10.022                    improves exercise capacity in individuals with type  2
                                                                  diabetes. Diabetes Care. 2005;28:2877-2883.
            40.  Guerrieri D, Moon HY, van Praag H. Exercise in a pill: The
               latest on exercise-mimetics. Brain Plast. 2017;2:153-169.     doi: 10.2337/diacare.28.12.2877
               doi: 10.3233/BPL-160043                         52.  Roi GS, Garagiola U, Verza P, et al. Aspirin does not affect
                                                                  exercise performance. Int J Sports Med. 1994;15:224-227.
            41.  Gubert C, Hannan AJ. Exercise mimetics: Harnessing the
               therapeutic effects of physical activity. Nat Rev Drug Discov.      doi: 10.1055/s-2007-1021050
               2021;20:862-879.                                53.  Rencurel F, Stenhouse A, Hawley SA, et al. AMP-activated
               doi: 10.1038/s41573-021-00217-1                    protein kinase mediates phenobarbital induction of CYP2B
                                                                  gene expression in hepatocytes and a newly derived human
            42.  Ouchi N, Shibata R, Walsh K. AMP-activated protein kinase   hepatoma cell line. J Biol Chem. 2005;280:4367-4373.
               signaling stimulates VEGF expression and angiogenesis in
               skeletal muscle. Circ Res. 2005;96:838-846.        doi: 10.1074/jbc.M412711200
               doi: 10.1161/01.RES.0000163633.10240.3b         54.  Feng X, Luo Z, Ma L, et al. Angiotensin II receptor blocker
                                                                  telmisartan enhances running endurance of skeletal muscle
            43.  Treins C, Murdaca J, Van Obberghen E, Giorgetti-Peraldi S.   through activation of the PPAR-δ/AMPK pathway.  J  Cell
               AMPK  activation  inhibits the  expression  of  HIF-1alpha   Mol Med. 2011;15:1572-1581.
               induced by insulin and IGF-1.  Biochem Biophys Res
               Commun. 2006;342:1197-1202.                        doi: 10.1111/j.1582-4934.2010.01085.x
               doi: 10.1016/j.bbrc.2006.02.088                 55.  Hart N, Sarga L, Csende Z,  et al. Resveratrol attenuates
                                                                  exercise-induced adaptive responses in rats selectively bred
            44.  Kobilo T, Guerrieri D, Zhang Y, Collica SC, Becker KG, van   for low running performance. Dose Response. 2013;12:57-71.
               Praag H. AMPK agonist AICAR improves cognition and
               motor coordination in young and aged mice. Learn Mem.      doi: 10.2203/dose-response.13-010.Radak
               2014;21:119-126.                                56.  Mnatsakanyan N, Jonas EA. The new role of F F  ATP
                                                                                                       1 o
               doi: 10.1101/lm.033332.113                         synthase in mitochondria-mediated neurodegeneration and
                                                                  neuroprotection. Exp Neurol. 2020;332:113400.
            45.  Guerrieri D, van Praag H. Exercise-mimetic AICAR
               transiently  benefits  brain  function.  Oncotarget.      doi: 10.1016/j.expneurol.2020.113400
               2015;6:18293-18313.                             57.  Althaher AR, Alwahsh M. An overview of ATP synthase,
               doi: 10.18632/oncotarget.4715                      inhibitors, and their toxicity. Heliyon. 2023;9:e22459.
            46.  Hawley SA, Ross FA, Chevtzoff C, et al. Use of cells expressing      doi: 10.1016/j.heliyon.2023.e22459
               gamma subunit variants to identify diverse mechanisms of   58.  Zheng J, Ramirez VD. Inhibition of mitochondrial
               AMPK activation. Cell Metab. 2010;11:554-565.      proton F0F1-ATPase/ATP synthase by polyphenolic
               doi: 10.1016/j.cmet.2010.04.001                    phytochemicals. Br J Pharmacol. 2000;130:1115-1123.
            47.  Jeon SM. Regulation and function of AMPK in physiology      doi: 10.1038/sj.bjp.0703397
               and diseases. Exp Mol Med. 2016;48:e245.        59.  Fang X, Wu H, Wei J, Miao R, Zhang Y, Tian J. Research
               doi: 10.1038/emm.2016.81                           progress on the pharmacological effects of berberine
                                                                  targeting mitochondria.  Front Endocrinol (Lausanne).
            48.  Marino A, Hausenloy DJ, Andreadou I, Horman S,   2022;13:982145.
               Bertrand  L, Beauloye C. AMP-activated protein kinase:
               A remarkable contributor to preserve a healthy heart against      doi: 10.3389/fendo.2022.982145
               ROS injury. Free Radic Biol Med. 2021;166:238-254.  60.  Liu Z, Cui C, Xu P, et al. Curcumin activates AMPK pathway
               doi: 10.1016/j.freeradbiomed.2021.02.047           and regulates lipid metabolism in rats following prolonged
                                                                  clozapine exposure. Front Neurosci. 2017;11:558.
            49.  Foretz  M,  Guigas  B,  Viollet  B.  Metformin:  Update  on
               mechanisms of action and repurposing potential. Nat Rev      doi: 10.3389/fnins.2017.00558
               Endocrinol. 2023;19:460-476.
                                                               61.  Zhang X, Wang L, Guo R, et al. Ginsenoside Rb1 ameliorates
               doi: 10.1038/s41574-023-00833-4                    diabetic arterial stiffening  via AMPK pathway.  Front


             Volume 8 Issue 2 (2025)                        12                               doi: 10.36922/itps.4852
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