Page 18 - ITPS-8-2
P. 18
INNOSC Theranostics and
Pharmacological Sciences AMPK in metabolism, energy and aging
the cellular and molecular mechanisms of physical activity- 50. Möller I, Wintermeyer A, Bender K, et al. Screening for the
induced health benefits. Cell Metab. 2015;22:4-11. synthetic cannabinoid JWH-018 and its major metabolites
in human doping controls. Drug Test Anal. 2011;3:609-620.
doi: 10.1016/j.cmet.2015.05.011
39. Fan W, Evans RM. Exercise mimetics: Impact on health and doi: 10.1002/dta.158
performance. Cell Metab. 2017;25:242-247. 51. Regensteiner JG, Bauer TA, Reusch JE. Rosiglitazone
doi: 10.1016/j.cmet.2016.10.022 improves exercise capacity in individuals with type 2
diabetes. Diabetes Care. 2005;28:2877-2883.
40. Guerrieri D, Moon HY, van Praag H. Exercise in a pill: The
latest on exercise-mimetics. Brain Plast. 2017;2:153-169. doi: 10.2337/diacare.28.12.2877
doi: 10.3233/BPL-160043 52. Roi GS, Garagiola U, Verza P, et al. Aspirin does not affect
exercise performance. Int J Sports Med. 1994;15:224-227.
41. Gubert C, Hannan AJ. Exercise mimetics: Harnessing the
therapeutic effects of physical activity. Nat Rev Drug Discov. doi: 10.1055/s-2007-1021050
2021;20:862-879. 53. Rencurel F, Stenhouse A, Hawley SA, et al. AMP-activated
doi: 10.1038/s41573-021-00217-1 protein kinase mediates phenobarbital induction of CYP2B
gene expression in hepatocytes and a newly derived human
42. Ouchi N, Shibata R, Walsh K. AMP-activated protein kinase hepatoma cell line. J Biol Chem. 2005;280:4367-4373.
signaling stimulates VEGF expression and angiogenesis in
skeletal muscle. Circ Res. 2005;96:838-846. doi: 10.1074/jbc.M412711200
doi: 10.1161/01.RES.0000163633.10240.3b 54. Feng X, Luo Z, Ma L, et al. Angiotensin II receptor blocker
telmisartan enhances running endurance of skeletal muscle
43. Treins C, Murdaca J, Van Obberghen E, Giorgetti-Peraldi S. through activation of the PPAR-δ/AMPK pathway. J Cell
AMPK activation inhibits the expression of HIF-1alpha Mol Med. 2011;15:1572-1581.
induced by insulin and IGF-1. Biochem Biophys Res
Commun. 2006;342:1197-1202. doi: 10.1111/j.1582-4934.2010.01085.x
doi: 10.1016/j.bbrc.2006.02.088 55. Hart N, Sarga L, Csende Z, et al. Resveratrol attenuates
exercise-induced adaptive responses in rats selectively bred
44. Kobilo T, Guerrieri D, Zhang Y, Collica SC, Becker KG, van for low running performance. Dose Response. 2013;12:57-71.
Praag H. AMPK agonist AICAR improves cognition and
motor coordination in young and aged mice. Learn Mem. doi: 10.2203/dose-response.13-010.Radak
2014;21:119-126. 56. Mnatsakanyan N, Jonas EA. The new role of F F ATP
1 o
doi: 10.1101/lm.033332.113 synthase in mitochondria-mediated neurodegeneration and
neuroprotection. Exp Neurol. 2020;332:113400.
45. Guerrieri D, van Praag H. Exercise-mimetic AICAR
transiently benefits brain function. Oncotarget. doi: 10.1016/j.expneurol.2020.113400
2015;6:18293-18313. 57. Althaher AR, Alwahsh M. An overview of ATP synthase,
doi: 10.18632/oncotarget.4715 inhibitors, and their toxicity. Heliyon. 2023;9:e22459.
46. Hawley SA, Ross FA, Chevtzoff C, et al. Use of cells expressing doi: 10.1016/j.heliyon.2023.e22459
gamma subunit variants to identify diverse mechanisms of 58. Zheng J, Ramirez VD. Inhibition of mitochondrial
AMPK activation. Cell Metab. 2010;11:554-565. proton F0F1-ATPase/ATP synthase by polyphenolic
doi: 10.1016/j.cmet.2010.04.001 phytochemicals. Br J Pharmacol. 2000;130:1115-1123.
47. Jeon SM. Regulation and function of AMPK in physiology doi: 10.1038/sj.bjp.0703397
and diseases. Exp Mol Med. 2016;48:e245. 59. Fang X, Wu H, Wei J, Miao R, Zhang Y, Tian J. Research
doi: 10.1038/emm.2016.81 progress on the pharmacological effects of berberine
targeting mitochondria. Front Endocrinol (Lausanne).
48. Marino A, Hausenloy DJ, Andreadou I, Horman S, 2022;13:982145.
Bertrand L, Beauloye C. AMP-activated protein kinase:
A remarkable contributor to preserve a healthy heart against doi: 10.3389/fendo.2022.982145
ROS injury. Free Radic Biol Med. 2021;166:238-254. 60. Liu Z, Cui C, Xu P, et al. Curcumin activates AMPK pathway
doi: 10.1016/j.freeradbiomed.2021.02.047 and regulates lipid metabolism in rats following prolonged
clozapine exposure. Front Neurosci. 2017;11:558.
49. Foretz M, Guigas B, Viollet B. Metformin: Update on
mechanisms of action and repurposing potential. Nat Rev doi: 10.3389/fnins.2017.00558
Endocrinol. 2023;19:460-476.
61. Zhang X, Wang L, Guo R, et al. Ginsenoside Rb1 ameliorates
doi: 10.1038/s41574-023-00833-4 diabetic arterial stiffening via AMPK pathway. Front
Volume 8 Issue 2 (2025) 12 doi: 10.36922/itps.4852