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INNOSC Theranostics and
Pharmacological Sciences AMPK in metabolism, energy and aging

uptake. Arch Biochem Biophys. 2011;509:142-146. Endocannabinoid levels in rat limbic forebrain and
hypothalamus in relation to fasting, feeding and satiation:
doi: 10.1016/j.abb.2011.03.005
Stimulation of eating by 2-arachidonoyl glycerol. Br J
106. Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Pharmacol. 2002;136:550-557.
Aja S. AMPK in the brain: Its roles in energy balance and
neuroprotection. J Neurochem. 2009;109:17-23. doi: 10.1038/sj.bjp.0704767
117. Di Marzo V, Goparaju SK, Wang L, et al. Leptin-regulated
doi: 10.1111/j.1471-4159.2009.05916.x
endocannabinoids are involved in maintaining food intake.
107. Oh TS, Cho H, Cho JH, Yu SW, Kim EK. Hypothalamic Nature. 2001;410:822-825.
AMPK-induced autophagy increases food intake by
regulating NPY and POMC expression. Autophagy. doi: 10.1038/35071088
2016;12:2009-2025. 118. Bullón P, Alcocer-Gómez E, Carrión AM, et al. AMPK
phosphorylation modulates pain by activation of NLRP3
doi: 10.1080/15548627.2016.1215382
inflammasome. Antioxid Redox Signal. 2016;24:157-170.
108. Lim CT, Kola B, Korbonits M. AMPK as a mediator of
hormonal signalling. J Mol Endocrinol. 2010;44:87-97. doi: 10.1089/ars.2014.6120
doi: 10.1677/JME-09-0063 119. Russe OQ, Möser CV, Kynast KL, et al. Activation of the
AMP-activated protein kinase reduces inflammatory
109. Rosso P, Fioramonti M, Fracassi A, et al. AMPK in the nociception. J Pain. 2013;14:1330-1340.
central nervous system: Physiological roles and pathological
implications. Res Rep Biol. 2016;7:1-13. doi: 10.1016/j.jpain.2013.05.012
doi: 10.2147/RRB.S90858 120. Sun LJ, Yu JW, Wan L, Zhang XY, Shi YG, Chen MY.
Endocannabinoid system activation contributes to glucose
110. Kola B, Boscaro M, Rutter GA, Grossman AB, Korbonits M. metabolism disorders of hepatocytes and promotes hepatitis
Expanding role of AMPK in endocrinology. Trends C virus replication. Int J Infect Dis. 2014;23:75-81.
Endocrinol Metab. 2006;17:205-215.
doi: 10.1016/j.ijid.2013.12.017
doi: 10.1016/j.tem.2006.05.006
121. Borgquist A, Meza C, Wagner EJ. The role of AMP-
111. Kola B, Hubina E, Tucci SA, et al. Cannabinoids and ghrelin activated protein kinase in the androgenic potentiation of
have both central and peripheral metabolic and cardiac cannabinoid-induced changes in energy homeostasis. Am J
effects via AMP-activated protein kinase. J Biol Chem. Physiol Endocrinol Metab. 2015;308:E482-E495.
2005;280:25196-25201.
doi: 10.1152/ajpendo.00421.2014
doi: 10.1074/jbc.C500175200
122. Hanus L, Avraham Y, Ben-Shushan D, Zolotarev O,
112. Wittmann G, Deli L, Kalló I, et al. Distribution of type 1 Berry EM, Mechoulam R. Short-term fasting and prolonged
cannabinoid receptor (CB1)-immunoreactive axons in the semistarvation have opposite effects on 2-AG levels in
mouse hypothalamus. J Comp Neurol. 2007;503:270-279. mouse brain. Brain Res. 2003;983:144-151.

doi: 10.1002/cne.21383 doi: 10.1016/s0006-8993(03)03046-4
113. Cota D, Marsicano G, Tschöp M, et al. The endogenous 123. Rosen ED, Spiegelman BM. Adipocytes as regulators
cannabinoid system affects energy balance via central of energy balance and glucose homeostasis. Nature.
orexigenic drive and peripheral lipogenesis. J Clin Invest. 2006;444:847-853.
2003;112:423-431.
doi: 10.1038/nature05483
doi: 10.1172/JCI17725
124. Cristino L, Luongo L, Imperatore R, et al. Orexin-A
114. Christ-Crain M, Kola B, Lolli F, et al. AMP-activated protein and endocannabinoid activation of the descending
kinase mediates glucocorticoid-induced metabolic changes: antinociceptive pathway underlies altered pain perception
A novel mechanism in Cushing’s syndrome. FASEB J. in leptin signaling deficiency. Neuropsychopharmacology.
2008;22:1672-1683. 2016;41:508-520.
doi: 10.1096/fj.07-094144 doi: 10.1038/npp.2015.173
115. Hiley CR, Ford WR. Cannabinoid pharmacology in the 125. King-Himmelreich TS, Möser CV, Wolters MC, et al. AMP-
cardiovascular system: Potential protective mechanisms activated kinase and the endogenous endocannabinoid
through lipid signalling. Biol Rev Camb Philos Soc. system might contribute to antinociceptive effects of
2004;79:187-205. prolonged moderate caloric restriction in mice. Mol Pain.
doi: 10.1017/s1464793103006201 2017;13:1744806917703111.
116. Kirkham TC, Williams CM, Fezza F, Di Marzo V. doi: 10.1177/1744806917703111

Volume 8 Issue 2 (2025) 15 doi: 10.36922/itps.4852