Page 49 - ITPS-8-2

INNOSC Theranostics and
Pharmacological Sciences MDD biomarkers: Clinical implications

33. Li-Juan N, Feng S, Ya-Yun X, et al. L-Carnitine and Acetyl- doi: 10.1200/JCO.2024.42.16_suppl.e13045
L-Carnitine: Potential Novel Biomarkers for Major Depressive 44. Cattaneo A, Gennarelli M, Uher R, et al. Candidate
Disorder. Research Square [Preprint]; 2020.
genes expression profile associated with antidepressants
doi: 10.21203/rs.3.rs-60837/v1 response in the GENDEP study: Differentiating
between baseline ‘predictors’ and longitudinal ‘targets’.
34. Nasca C, Lee FS, Young SP, et al. Acetyl-l-carnitine deficiency
in patients with major depressive disorder. Proc Natl Acad Neuropsychopharmacology. 2013;38(3):377-85.
Sci U S A. 2018;115(34):8627-8632. doi: 10.1038/npp.2012.191
doi: 10.1073/pnas.1801609115 45. Lin CH, Huang MW, Lin CH, Huang CH, Lane HY. Altered
mRNA expressions for N-methyl-D-aspartate receptor-
35. Du F, Yu Q, Swerdlow RH, Waites CL. Glucocorticoid-
driven mitochondrial damage stimulates Tau pathology. related genes in WBC of patients with major depressive
Brain. 2023;146(10):4378-4394. disorder. J Affect Disord. 2019;245:1119-1125.
doi: 10.1016/j.jad.2018.12.016
doi: 10.1093/brain/awad127
46. Chimienti F, Cavarec L, Vincent L, et al. Brain region-
36. Sharma VK, Singh TG, Mehta V, Mannan A. Biomarkers:
Role and scope in neurological disorders. Neurochem Res. specific alterations of RNA editing in PDE8A mRNA in
2023;48(7):2029-2058. suicide decedents. Transl Psychiatry. 2019;9(1):91.
doi: 10.1038/s41398-018-0331-3
doi: 10.1007/s11064-023-03873-4
47. Salvetat N, Van der Laan S, Vire B, et al. RNA editing
37. Cattaneo A, Ferrari C, Uher R, Bocchio-Chiavetto L,
Riva MA, Pariante CM. Absolute measurements of blood biomarkers for predicting mood alterations in HCV
macrophage migration inhibitory factor and interleukin- patients. J Neurovirol. 2019;25(6):825-836.
1-β mRNA levels accurately predict treatment response doi: 10.1007/s13365-019-00772-9
in depressed patients. Int J Neuropsychopharmacol. 48. Rotter A, Lenz B, Pitsch R, Richter-Schmidinger T,
2016;19(10):pyw045.
Kornhuber J, Rhein C. Alpha-synuclein RNA expression is
doi: 10.1093/ijnp/pyw045 increased in major depression. Int J Mol Sci. 2019;20(8):2029.
38. Feng J, Wang M, Li M, et al. Serum miR-221-3p as a new doi: 10.3390/ijms20082029
potential biomarker for depressed mood in perioperative 49. Villanueva-Charbonneau G, Potvin S, Marchand S, et al.
patients. Brain Res. 2019;1720:146296.
Serotonin transporter mRNA expression is reduced in
doi: 10.1016/j.brainres.2019.06.015 the peripheral blood mononuclear cells of subjects with
major depression but normal in fibromyalgia. Brain Sci.
39. Liu Z, Li X, Chen C, et al. Identification of antisense lncRNAs
targeting GSK3β as a regulator in major depressive disorder. 2023;13(10):1485.
Epigenomics. 2020;12(19):1725-1738. doi: 10.3390/brainsci13101485
doi: 10.2217/epi-2019-0402 50. Roy B, Yoshino Y, Allen L, Prall K, Schell G, Dwivedi Y.
Exploiting circulating microRNAs as biomarkers in
40. Cui X, Niu W, Kong L, et al. Hsa_circRNA_103636: Potential
novel diagnostic and therapeutic biomarker in Major psychiatric disorders. Mol Diagn Ther. 2020;24(3):279-298.
depressive disorder. Biomarker Med. 2016;10(9):943-952. doi: 10.1007/s40291-020-00464-9
41. Numata S, Ishii K, Tajima A, et al. Blood diagnostic 51. Fan HM, Sun XY, Guo W, et al. Differential expression of
biomarkers for major depressive disorder using multiplex microRNA in peripheral blood mononuclear cells as specific
DNA methylation profiles: Discovery and validation. biomarker for major depressive disorder patients. J Psychiatr
Epigenetics. 2015;10(2):135-141. Res. 2014;59:45-52.
doi: 10.1080/15592294.2014.1003743 doi: 10.1016/j.jpsychires.2014.08.007
42. Hicks EM, Seah C, Cote A, et al. Integrating genetics 52. Lopez JP, Fiori LM, Cruceanu C, et al. MicroRNAs 146a/
and transcriptomics to study major depressive disorder: b-5 and 425-3p and 24-3p are markers of antidepressant
A conceptual framework, bioinformatic approaches, and response and regulate MAPK/Wnt-system genes. Nat
recent findings. Transl Psychiatry. 2023;13(1):129. Commun. 2017;8:15497.
doi: 10.1038/s41398-023-02412-7 doi: 10.1038/ncomms15497
43. Guo W, Tan J, Chan B, et al. Transcriptomic analysis of the 53. Qiao-Li Z, Xin-Yang S, Wei G, et al. A preliminary analysis of
tumor immune microenvironment (TIME) in patients with association between plasma microRNA expression alteration
breast cancer with liver metastasis (BCLM). J Clin Oncol. and symptomatology improvement in Major Depressive
2024;42:e13045-e13045. Disorder (MDD) patients before and after antidepressant

Volume 8 Issue 2 (2025) 43 doi: 10.36922/itps.4404