Page 50 - ITPS-8-2

INNOSC Theranostics and
Pharmacological Sciences MDD biomarkers: Clinical implications

treatment. Eur J Psychiatry. 2014;28(4):252-264. 64. Homorogan C, Enatescu VR, Nitusca D, Marcu A,
Seclaman E, Marian C. Distribution of microRNAs associated
54. Wan Y, Liu Y, Wang X, et al. Identification of differential
microRNAs in cerebrospinal fluid and serum of patients with with major depressive disorder among blood compartments.
major depressive disorder. PLoS One. 2015;10(3):e0121975. J Int Med Res. 2021;49(4):3000605211006633.
doi: 10.1371/journal.pone.0121975 doi: 10.1177/03000605211006633
55. Song R, Bai Y, Li X, et al. Plasma circular RNA DYM related 65. Kim HK, Tyryshkin K, Elmi N, et al. Plasma microRNA
to major depressive disorder and rapid antidepressant effect expression levels and their targeted pathways in patients
treated by visual cortical repetitive transcranial magnetic with major depressive disorder who are responsive to
stimulation. J Affect Disord. 2020;274:486-493. duloxetine treatment. J Psychiatr Res. 2019;110:38-44.
doi: 10.1016/j.jad.2020.05.109 doi: 10.1016/j.jpsychires.2018.12.007
56. Maffioletti E, Cattaneo A, Rosso G, et al. Peripheral whole 66. Qi B, Fiori LM, Turecki G, Trakadis YJ. Machine learning
blood microRNA alterations in major depression and analysis of blood microRNA Data in major depression:
bipolar disorder. J Affect Disord. 2016;200:250-258. A case-control study for biomarker discovery. Int J
Neuropsychopharmacol. 2020;23(8):505-510.
doi: 10.1016/j.jad.2016.04.021
doi: 10.1093/ijnp/pyaa029
57. Zhao L, Yang X, Cui L, et al. Increased expression of a novel
miRNA in peripheral blood is negatively correlated with 67. Marshe VS, Islam F, Maciukiewicz M, et al. Validation study
hippocampal volume in patients with major depressive of microRNAs previously associated with antidepressant
disorder. J Affect Disord. 2019;245:205-212. response in older adults treated for late-life depression with
venlafaxine. Prog Neuropsychopharmacol Biol Psychiatry.
doi: 10.1016/j.jad.2018.10.363
2020;100:109867.
58. Lou D, Wang J, Wang X. miR-124 ameliorates depressive- doi: 10.1016/j.pnpbp.2020.109867
like behavior by targeting STAT3 to regulate microglial
activation. Mol Cell Probes. 2019;48:101470. 68. Torres-Berrio A, Nouel D, Cuesta S, et al. MiR-218:
A molecular switch and potential biomarker of susceptibility
doi: 10.1016/j.mcp.2019.101470
to stress. Mol Psychiatry. 2020;25(5):951-964.
59. Hung YY, Wu MK, Tsai MC, Huang YL, Kang HY. Aberrant
expression of intracellular let-7e, miR-146a, and miR-155 doi: 10.1038/s41380-019-0421-5
correlates with severity of depression in patients with major 69. Bian Y, Yang L, Wang Z, et al. Integrated Analysis Profiles of
depressive disorder and is ameliorated after antidepressant Long Non-Coding RNAs Reveal Potential Biomarkers Across
treatment. Cells. 2019;8(7):647. Brain Regions in Post-Traumatic Stress Disorder. Research
doi: 10.3390/cells8070647 Square [Preprint]; 2020.
60. Mendes-Silva AP, Fujimura PT, Silva J, et al. Brain-enriched doi: 10.21203/rs.3.rs-15824/v1
microRNA-184 is downregulated in older adults with major 70. Liu Z, Li X, Sun N, et al. Microarray profiling and
depressive disorder: A translational study. J Psychiatr Res. co-expression network analysis of circulating lncRNAs and
2019;111:110-120. mRNAs associated with major depressive disorder. PLoS
doi: 10.1016/j.jpsychires.2019.01.019 One. 2014;9(3):e93388.
61. Zhang Y, Du L, Bai Y, et al. CircDYM ameliorates depressive- doi: 10.1371/journal.pone.0093388
like behavior by targeting miR-9 to regulate microglial 71. Cui X, Sun X, Niu W, et al. Long non-coding RNA: Potential
activation via HSP90 ubiquitination. Mol Psychiatry. diagnostic and therapeutic biomarker for major depressive
2020;25(6):1175-1190. disorder. Med Sci Monit. 2016;22:5240-5248.
doi: 10.1038/s41380-018-0285-0 doi: 10.12659/msm.899372
62. Ibrahim P, Denniston R, Mitsuhashi H, et al. Profiling small 72. Cui X, Niu W, Kong L, et al. Can lncRNAs be indicators
RNA from brain extracellular vesicles in individuals with for the diagnosis of early onset or acute schizophrenia
depression. Int J Neuropsychopharmacol. 2024;27(3):pyae013. and distinguish major depressive disorder and generalized
doi: 10.1093/ijnp/pyae013 anxiety disorder?-A cross validation analysis. Am J Med
Genet B Neuropsychiatr Genet. 2017;174(4):335-341.
63. Wang H, Liu L, Chen X, et al. MicroRNA-messenger
RNA regulatory network mediates disrupted TH17 doi: 10.1002/ajmg.b.32521
cell differentiation in depression. Front Psychiatry. 73. Seki T, Yamagata H, Uchida S, et al. Altered expression of
2022;13:824209.
long noncoding RNAs in patients with major depressive
doi: 10.3389/fpsyt.2022.824209 disorder. J Psychiatr Res. 2019;117:92-99.

Volume 8 Issue 2 (2025) 44 doi: 10.36922/itps.4404