Page 29 - JCBP-1-1

Journal of Clinical and

Basic Psychosomatics

ORIGINAL RESEARCH ARTICLE
A higher risk for melanoma in patients with

Parkinson’s disease: Based on the results from
National Health and Nutrition Examination

Survey 2001 – 2004

2
3
1
3
Huan Chen , Ning Du , Lixia Wang *, and Lin Yang *
1 Department of Dermatology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China
2 Department of Psychiatry, University-Town Hospital of Chongqing Medical University, Chongqing,
China
3 Department of Neurology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China

Abstract

The relationship between Parkinson’s disease (PD) and melanoma has been
controversial. The present study used data from the 2001 – 2004 National Health
and Nutrition Examination Survey database. This study included individuals
aged ≥20 years with complete data on PD and melanoma, in which 48 participants
were comorbid with the melanoma group, and 5774 were not. Both univariate
*Corresponding authors: and multivariate logistic regression analyses were conducted to investigate the
Lixia Wang connection. There was a higher proportion of PD in the melanoma group than in
(xial2023@163.com)
Lin Yang the non-melanoma group (2.45% vs. 0.30%). Univariate logistic regression analysis
(yanglin20230328@126.com) revealed that individuals with PD had an 8.32-fold higher risk of developing
Citation: Chen H, Du N, Wang L, melanoma than those without PD. In addition, PD was significantly correlated with
et al., 2023, A higher risk for melanoma (OR, 8.747; 95% CI, 1.264 – 60.506; p = 0.030) after controlling for covariates
melanoma in patients with in multivariate analysis. In conclusion, our research indicates a significant correlation
Parkinson’s disease: Based on
the results from National Health between PD and melanoma in American adults.
and Nutrition Examination Survey
2001 – 2004. Journal of Clinical and
Basic Psychosomatics, 1(1): 0571. Keywords: Parkinson’s disease; National Health and Nutrition Examination Survey;
https://doi.org/10.36922/jcbp.0571 Melanoma; Comorbidity; Sampling weights
Received: April 18, 2023
Accepted: May 30, 2023
Published Online: June 26, 2023 1. Introduction
Copyright: © 2023 Author(s). The prevalence of melanoma is rising annually, making it one of the five most common
This is an Open-Access article cancers in the United States . It is particularly aggressive, with a tendency to develop
[1]
distributed under the terms of the
Creative Commons Attribution quickly, a high risk of metastasis, and a poor prognosis. However, the poor prognosis of
License, permitting distribution, and melanoma is only due to delayed diagnosis. The average 5-year survival rate for all stages
reproduction in any medium, which of melanoma in the U.S. is 94%. The estimated 5-year survival rate for patients whose
provided that the original work is
[2]
properly cited. melanoma is detected early is over 99% . Furthermore, the etiology of this melanocytic
malignancy is multifactorial and complex.
Publisher’s Note: AccScience
Publishing remains neutral with Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the
regard to jurisdictional claims in [3]
published maps and institutional destruction of dopaminergic neurons in the substantia nigra densa , as well as the
[4]
affiliations. reduction of dopamine in the striatum and the presence of Lewy bodies . The link between

Volume 1 Issue 1 (2023) 1 https://doi.org/10.36922/jcbp.0571