Page 33 - JCBP-1-1

Journal of Clinical and
Basic Psychosomatics Relationship between PD and melanoma based on NHANES

hydroxylase, and peroxidase . Furthermore, it has also Funding
[15]
been suggested that Parkin inactivation (loss-of-function
mutations in PARK2), typically found in young-onset This work was supported by Science and Technology
Plan of Yunnan Provincial Department of Science and
PD, may also enhance melanoma susceptibility and Technology (202101BA070001-205).
progression . Furthermore, flaws in cellular processes,
[16]
such as autophagy and proteostasis, may also be linked Conflict of interest
to the co-occurrence of the two diseases [17-19] . Moreover,
changes in melanin deposition and/or enzymes related The authors have no conflicts of interest to declare.
to melanin synthesis are essential areas where these two Author contributions
distinct diseases intersect [20-22] .
Conceptualization: Huan Chen, Lin Yang
The advantages of this study are as follows: (i) The Formal analysis: Ning Du
utilization of the NHANES database, which is relatively Investigation: Huan Chen, Ning Du, Lixia Wang
standardized and thus increases the accuracy of the results; Methodology: Huan Chen
(ii) the large sample size, standardized data collection, Writing – original draft: Huan Chen
and reliable information, which make the cross-sectional Writing – review & editing: Huan Chen
study more objective; and (iii) the construction of multiple
models to adjust for confounding factors to confirm the Ethics approval and consent to participate
relationship between PD and melanoma, resulting in Ethical review and approval were waived for this study due
relatively reliable results. Nevertheless, there are also some to the fact that NHANES surveys were previously reviewed
drawbacks. To begin with, the small number of patients and approved by the Centers for Disease Control (CDC)
with both PD and melanoma in our study (n = 1) may have and Prevention National Center for Health Statistics
caused some bias in the results, leading to a higher risk (NCHS) Research Ethics Review Board (Atlanta, U.S.).
multiplier. In addition, the data we analyzed were from U.S.
citizens, so the results of this study may not be applicable Consent for publication
to populations in Asian countries or other regions or Not applicable.
countries. In addition, the melanoma data section in
the NHANES database has not been updated in recent Availability of data
years, lacking recent data to support the hypothesized
relationship between PD and melanoma. Finally, compared Publicly available datasets were analyzed in this study. These
to longitudinal studies, the present study has less evidence datasets can be found here: https://wwwn.cdc.gov/nchs/
of causality since it is a cross-sectional study. nhanes/ContinuousNhanes/Default.aspx?BeginYear= 2005.

Despite the limitations of this study, it is essential to References
emphasize the potential risk of melanoma comorbidities 1. Siegel RL, Miller KD, Jemal A, 2019, Cancer statistics, 2019.
in patients with PD, and to actively implement preventive CA Cancer J Clin, 69: 7 – 34.
and therapeutic interventions to reduce the likelihood of https://doi.org/10.3322/caac.21551
comorbidities and improving the quality of patients’ life.
In addition, it is imperative to conduct prospective, multi- 2. Lyakhov PA, Lyakhova UA, Nagornov NN, 2022, System
center, and large-sample-size clinical studies in the future for the recognizing of pigmented skin lesions with fusion
to explore and elucidate the intricate relationship between and analysis of heterogeneous data based on a multimodal
neural network. Cancers (Basel), 14: 1819.
PD and melanoma.
https://doi.org/10.3390/cancers14071819
5. Conclusion 3. Brot S, Thamrin NP, Bonnet ML, et al., 2022, Long-term
Our research indicates that there is a significant correlation evaluation of intranigral transplantation of human iPSC-
between PD and melanoma in American adults. derived dopamine neurons in a Parkinson’s disease mouse
model. Cells, 11: 1596.
Acknowledgments https://doi.org/10.3390/cells11101596
The authors thank Zhang Jing of Shanghai Tongren 4. Gao H, Sun H, Yan N, et al., 2022, ATP13A2 declines zinc-
Hospital for his exemplary work on the NHANES database. induced accumulation of α-synuclein in a Parkinson’s
His remarkable nhanesR package and webpage have makes disease model. Int J Mol Sci, 23: 8035.
data more accessible. https://doi.org/10.3390/ijms23148035

Volume 1 Issue 1 (2023) 5 https://doi.org/10.36922/jcbp.0571