Page 40 - JCBP-1-2

Journal of Clinical and

Basic Psychosomatics

ORIGINAL RESEARCH ARTICLE
Mutuality of thyroid hormones and psychiatric

disorders

1,2
Sandra Vuk Pisk *, Natko Gereš , Karla Laškarin , Katarina Matić ,
1
1,2
1
1,2
1
Nedjeljka Ruljančić , Ena Ivezić , and Igor Filipčić 1,2,3
1 Department of Integrative Psychiatry, University Psychiatric Hospital Sveti Ivan, Zagreb, Croatia
2 Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, “Josip Juraj
Strossmayer” University of Osijek, Osijek, Croatia
3 Department of Psychiatry and Neurology, School of Medicine, University of Zagreb, Zagreb, Croatia
Abstract

Abnormalities in thyroid function may induce affective, anxious, psychotic, and
cognitive disorders and are a potential marker for assessing suicidal risk in patients
suffering from psychiatric disorders. This retrospective, cross-sectional, electronic,
and data-based study, comprising 118 adult psychiatric patients, aimed to establish
differences in the concentrations of total T3, T4, and thyroid-stimulating hormone
among patients diagnosed with common psychiatric disorders. The analysis
encompassed the levels of these hormones in patients who had attempted suicide
and those who had not. Lower values of total T3 were observed in patients with
depressive disorder compared to patients with psychotic and bipolar disorder,
as well as the control group. Furthermore, lower total T3 values were observed
*Corresponding author: in patients who had reported a suicide attempt in their lives compared to
Sandra Vuk Pisk participants who had not attempted suicide. These findings suggest a potential
(sandra.pisk@pbsvi.hr)
link between thyroid hormones and the regulation of central serotonin activity.
Citation: Pisk SV, Gereš N, The study underscores the importance of routinely assessing thyroid function in
Laškarin K, et al., 2023, Mutuality
of thyroid hormones and psychiatric clinical practice to facilitate early detection of suicidality and the prevention of
disorders. J Clin Basic Psychosom, suicide.
1(2): 1130.
https://doi.org/10.36922/jcbp.1130
Keywords: Thyroid hormones; Hypothalamic-pituitary-adrenal axis; Suicide prevention;
Received: June 25, 2023
Psychiatric disorders; Suicidality
Accepted: August 23, 2023
Published Online: September 20,
2023
1. Introduction
Copyright: © 2023 Author(s).
This is an Open-Access article Thyroid dysfunction, both clinically significant and subclinical, affects 5 – 8% of the
distributed under the terms of the
[1]
Creative Commons Attribution general population . A study conducted in Tehran reported a significant increase in the
License, permitting distribution, prevalence rate of overall thyroid dysfunction, rising from 1.4% at baseline to 10.5% .
[2]
and reproduction in any medium, The prevalence of psychiatric disorders is higher among patients with various thyroid
provided the original work is
properly cited. dysfunctions compared to the general population. Indeed, observational studies have
linked both hypo and hyperthyroidism to affective disorders .
[3]
Publisher’s Note: AccScience
Publishing remains neutral with Abnormalities in thyroid function can induce affective, anxious, psychotic, and cognitive
regard to jurisdictional claims in [4,5]
published maps and institutional disorders . Furthermore, the degree of abnormality in the thyroid hormone levels
affiliations. correlates with the severity of psychopathological symptoms in psychiatric disorders [6,7] .

Volume 1 Issue 2 (2023) 1 https://doi.org/10.36922/jcbp.1130