Page 60 - JCBP-2-3

Journal of Clinical and
Basic Psychosomatics Proteomic analysis of mind-body psychotherapy in psoriasis

4.4. Stress and therapy in PS patients Acknowledgments

Our previous study showed that the skin symptoms of The authors would like to thank patients and HCs who
patients with psoriasis significantly improved after the contributed to the present study.
MMIP. Nowadays, studies have demonstrated that 37 –
25
88% of patients with psoriasis believe that their disease is Funding
caused or exacerbated by stress. Furthermore, the related This research was supported by the Natural Science
62
psychological problems can affect daily social activities and Foundation of Inner Mongolia Autonomous Region
work; it causes embarrassment, lack of self-esteem, anxiety, (2021MS08101), and partly supported by the Science
1
and an increased prevalence of depression. Therefore, and Technology Major Project of the Inner Mongolia
psychological interventions like relaxation therapy could Autonomous Region (NMGZDZX2017) and Mongolian
decrease disease severity and improve psoriasis patients’ Psychosomatic Medicine Innovation Talent Team Project
quality of life. In this study, we demonstrated for the first of the Ordos City (2021).
63
time that the proteomics analysis of the exosomes is helpful
at analyzing the therapeutic effect of MMIP. Conflict of interest
The limitation of the study was the small size of the The authors declare no conflicts of interest.
patients and healthy individuals enrolled. In the future,
plasma-derived exosomes and therapeutically effective Author contributions
exosomal proteins need to be further analyzed and verified Conceptualization: Haorile Chagan-Yasutan, Nagongbilige
in a large-scale population study to understand the He, Toshio Hattori
pathogenesis of psoriasis and determine the therapeutic Formal analysis: Haorile Chagan-Yasutan, Sarnai Arlud
targets. Here, we examined the effect of MMIP on Investigation: Haorile Chagan-Yasutan, Nagongbilige He,
exosomal proteome in selected patients with PASI 75; Sarnai Arlud, Siriguleng Wuyun
however, the clinical effect of MMIP on psoriasis needs Methodology: Ruiming Gao, Wenfeng Bao, Rihan Wu,
to be confirmed by a randomized controlled study in the Qiqige Gerile, Jiletu Xin
future. Nevertheless, the present study, for the first time, Writing–original draft: Haorile Chagan-Yasutan, Toshio
showed the biomolecular effect of MMIP and provided Hattori
novel insights into the pathophysiology of PS. Writing–review & editing: Haorile Chagan-Yasutan, Toshio
Hattori
5. Conclusion
Ethics approval and consent to participate
In this study, we conducted comparative proteomics
analysis of the exosomes derived from the plasma of MMIP- The study was conducted according to the code of ethics of
treated psoriasis patients and HCs. The results showed the World Medical Association (Declaration of Helsinki)
that the involvement of apelin signaling and ribosome and approved by the Ethical Committee Review Board of
pathways is pathologically associated with psoriasis. The the International Mongolian Medicine Hospital of Inner
potential involvement of a circuit comprising complement, Mongolia (2018-002). Written informed consent was
protease, and its inhibitor is postulated. MMIP therapy obtained from all of the participants.
attenuates the activation of actin-mediated inflammatory Consent for publication
pathways and alters Fc receptor-mediated phagocytosis
pathways as well as the pathways of tight junction and Written informed consent was obtained from all
vascular smooth muscle contraction. In addition, nine participants to publish their data. Moreover, the effort
types of immunoglobulins were decreased in psoriasis, has been made by authors to conceal any identifying
and one of them significantly increased after the MMIP. information of the participants that appear in the paper.
Further, validation study revealed that the levels of serum
ELAF were higher in psoriasis patients than in HCs and Availability of data
significantly decreased after MMIP. Thus, MMIP can Data are available from the corresponding author on
heighten immunity and suppress inflammation in psoriasis reasonable request.
patients at the biomolecular level. Through proteomics
analysis of plasma-derived exosomes, new insights into References
psoriasis pathology and therapeutic targets in MMIP are 1. World Health Organization. Global Report on Psoriasis.
unveiled. Geneva: World Health Organization; 2016.

Volume 2 Issue 3 (2024) 12 doi: 10.36922/jcbp.2381