Page 56 - JCBP-2-3

Journal of Clinical and
Basic Psychosomatics Proteomic analysis of mind-body psychotherapy in psoriasis

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Figure 2. Differentially expressed proteins (DEPs) identified in proteomics analysis comparing protein profiles between patients with psoriasis and HCs.
(A) Volcano plot shows significantly increased proteins (n = 23) and decreased proteins (n = 18) in patients with psoriasis. (B) Heatmap shows significantly
altered proteins between patients with psoriasis (Disease) and HCs (Health). (C) KEGG pathway analysis unveils two pathways involved in psoriasis. (D)
PPI figure shows the interaction of DEPs (Table 2 presents the full name of proteins).
Abbreviations: MMIP: Mongolian mind-body interactive psychotherapy; KEGG: Kyoto Encylopedia of Genes and Genomes; PPI: Protein-protein
interaction; HCs: Healthy controls.

In the KEGG pathway analysis, the pathway 3.5. Validation of elafin before and after therapy in
of Fc gamma R-mediated phagocytosis (https:// psoriasis patients
www.kegg.jp/dbget-bin/www_bget?map04666), The levels of ELAF were validated in serum samples
tight junction (https://www.kegg.jp/dbget-bin/ of MMIP-treated (n = 56) psoriasis patients and HCs
www_bget?map04530), and vascular smooth muscle (n = 29). The levels of ELAF were significantly elevated
contraction (https://www.kegg.jp/dbget-bin/www_ in psorisis patients (before therapy), as compared to HCs
bget?map04270) (Figure 3C) with the correlated (P < 0.0001), and significantly decreased after the MMIP
exosomal proteins of COF1, VASP, MYL6, and ACTA2 therapy (P < 0.01) (Figure 4). However, there was no
was significantly involved in the recovery of patients correlation between serum ELAF and PASI before and
with psoriasis by MMIP (Figure 3D). after the MMIP therapy.

Volume 2 Issue 3 (2024) 8 doi: 10.36922/jcbp.2381