Page 54 - JCBP-2-3

Journal of Clinical and
Basic Psychosomatics Proteomic analysis of mind-body psychotherapy in psoriasis

Table 2. List of exosomal proteins showing significant differences between psoriasis patients and healthy controls
S. No. UniProt entry ID Gene name Protein name Ratio Q value Up/
(disease/health) Downregulation
1 A2NYU9 N/A Heavy chain Fab (Fragment) 0.12 0.04 Down
2 P05121 PAI1 Plasminogen activator inhibitor 1 0.15 0.03 Down
3 Q13835 PKP1 Plakophilin-1 0.26 0.04 Down
4 Q04695 KRT17 Keratin, type I cytoskeletal 17 0.27 0.01 Down
5 P35754 GLRX Glutaredoxin-1 0.31 0.03 Down
6 Q6VFQ6 HBB Hemoglobin beta chain 0.32 0.01 Down
7 P37840 SNCA Alpha-synuclein 0.33 0.04 Down
8 P01860 IGHG3 Immunoglobulin heavy constant gamma 3 0.41 0.049 Down
9 A0A0C4DH68 IGKV2-24 Immunoglobulin kappa variable 2-24 0.44 0.01 Down
10 P22105 TENX Tenascin-X 0.46 0.03 Down
11 B2R582 N/A Highly similar to C-type lectin 0.47 0.03 Down
domain family 3, member B (CLEC3B)
12 P01591 JCHAIN Immunoglobulin J chain 0.49 0.02 Down
13 Q8NCL6 N/A highly similar to Ig alpha-1 chain C region 0.50 0.02 Down
14 P01871 IGHM Immunoglobulin heavy constant mu 0.53 0.04 Down
15 Q0ZCH6 N/A Immunoglobulin heavy chain variable region 0.58 0.04 Down
16 Q0ZCF9 N/A Immunglobulin heavy chain variable region 0.58 0.02 Down
17 B1N7B9 BMS1P20 Cryocrystalglobulin CC2 lambda light chain variable region 0.59 0.04 Down
18 P26572 MGAT1 Alpha-1,3-mannosyl-glycoprotein 0.63 0.05 Down
2-beta-N-acetylglucosaminyltransferase
19 P39060 COIA1 Collagen alpha-1(XVIII) chain 1.52 0.03 Up
20 Q13421 MSLN Mesothelin 1.58 0.02 Up
21 P62753 RS6 40S ribosomal protein S6 1.59 0.03 Up
22 Q9Y509 VH3 VH3 protein (Fragment) 1.61 0.02 Up
23 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1 1.62 0.03 Up
24 P04632 CPNS1 Calpain small subunit 1 1.63 0.04 Up
25 P01024 CO3 Complement C3 1.63 0.02 Up
26 O60282 KIF5C Kinesin heavy chain isoform 5C 1.65 0.02 Up
27 P62244 RS15A 40S ribosomal protein S15a 1.67 0.02 Up
28 Q9HCU4 CELR2 Cadherin EGF LAG seven-pass G-type receptor 2 1.69 0.04 Up
29 P61247 RS3A 40S ribosomal protein S3a 1.84 0.00 Up
30 P62736 ACTA2 Actin alpha 2, aortic smooth muscle 2 1.90 0.04 Up
31 Q9Y577 TRI17 E3 ubiquitin-protein ligase TRIM17 1.94 0.049 Up
32 P62266 RS23 40S ribosomal protein S23 1.96 0.01 Up
33 Q6P387 CP046 Uncharacterized protein C16orf46 2.36 0.01 Up
34 Q01518 CAP1 Adenylyl cyclase-associated protein 1 2.46 0.03 Up
35 P50552 VASP Vasodilator-stimulated phosphoprotein 2.55 0.02 Up
36 B4DRA0 N/A Highly similar to RNA-binding region-containing protein 2 3.12 0.02 Up
37 O00233 PSMD9 26S proteasome non-ATPase regulatory subunit 9 3.16 0.02 Up
38 P37802 TAGL2 Transgelin-2 3.20 0.04 Up
39 P58166 INHB Inhibin beta E chain 3.23 0.04 Up
40 Q6ZW64 N/A Highly similar to Protein Tro alpha1 H, myeloma 6.18 0.04 Up
41 P19957 ELAF Elafin 9.12 0.01 Up

Volume 2 Issue 3 (2024) 6 doi: 10.36922/jcbp.2381