Page 49 - JCBP-2-3

Journal of Clinical and

Basic Psychosomatics

ORIGINAL RESEARCH ARTICLE
Unraveling the biomolecular effects of

Mongolian mind-body interactive psychotherapy
on psoriasis: An exosome proteomic analysis

Haorile Chagan-Yasutan * , Nagongbilige He *, Sarnai Arlud 1 ,
1,3
1,2
4
3
4
Siriguleng Wuyun , Ruiming Gao 1 , Wenfeng Bao , Rihan Wu , Qiqige Gerile ,
1
Jiletu Xin , and Toshio Hattori 2,5
4
1 Department of Mongolian Psychosomatic Medicine, Inner Mongolia International Mongolian
Medicine Hospital, Hohhot, China
2 Research Institute of Health and Welfare, Kibi International University, 8-Iga-machi, Takahashi,
Okayama, Japan
3 The Inner Mongolia Institute of Chinese and Mongolian Medicine, Hohhot, China
4 Ordos Mongolian Medical Hospital, Kangbashi District, Ordos, Inner Mongolia Autonomous Region, China
5 Shizuoka Graduate University of Public Health, 4-27-2 Kita Ando Aoi-ku, Shizuoka City, Japan

Abstract

Psoriasis is a chronic inflammatory skin disease etiologically related to stress.
Mongolian mind-body interactive psychotherapy (MMIP) is a group psychotherapy
*Corresponding authors: that integrates traditional Mongolian medicine theory with modern psychology.
Haorile Chagan-Yasutan Exosomes are nanovesicles that carry biomolecules such as proteins, and the lipid
(haorile@gjmyemail.gjmyy.cn) bilayer protects cargo from degeneration. The present study was conducted to
Nagongbilige He discern the effects of MMIP on psoriasis from a biomolecular perspective, particularly
(nagongbilige@gjmyemail.gjmyy.cn)
by performing an exosome proteomic analysis. Plasma exosomes were extracted
Citation: Chagan-Yasutan H, from 15 samples, derived from psoriasis patients (n = 5, before and after MMIP) and
He N, Arlud S, et al. Unraveling healthy controls (HCs; n = 5). All patients had spent 60 days engaging with MMIP.
the biomolecular effects of
Mongolian mind-body interactive Proteomic analysis was conducted using high-throughput mass spectrometry, and
psychotherapy on psoriasis: An the differentially expressed proteins (DEPs) were analyzed. Further, validation test
exosome proteomic analysis. J Clin was done in serum samples of psoriasis (n = 56) and HC (n = 29). After the MMIP,
Basic Psychosom. 2024;2(3):2381.
doi: 10.36922/jcbp.2381 the psoriasis area and severity index improved by 75%. Compared to HCs, psoriasis
patients demonstrated alterations in 41 DEPs, with significant involvement of
Received: December 6, 2023 ribosome and apelin/APJ pathway. The recovery of psoriasis following the therapy was
Accepted: April 24, 2024 found to be associated with significant alterations in 16 DEPs, involving pathways of Fc
gamma-mediated receptor phagocytosis, tight junction, and vascular smooth muscle
Published Online: May 24, 2024
contraction. Notably, one of the immunoglobulins that were reduced in psoriasis
Copyright: © 2024 Author(s). was significantly elevated after the MMIP. Validation results showed that the levels of
This is an Open-Access article
distributed under the terms of the serum elafin were higher in psoriasis than in HC but significantly decreased after MMIP.
Creative Commons Attribution In conclusion, this study demonstrated that MMIP has a significant influence on the
License, permitting distribution, profiles of immunoglobulins and inflammatory molecules, as well as several pathways
and reproduction in any medium, participating in the psoriasis recovery, providing insights into the pathophysiology of
provided the original work is
properly cited. psoriasis and possible potential therapeutic targets of the disease.
Publisher’s Note: AccScience
Publishing remains neutral with Keywords: Psoriasis; Plasma exosome; Proteomic analysis; Mongolian mind-body
regard to jurisdictional claims in
published maps and institutional interactive psychotherapy; Stress; Group psychotherapy; Biomarker; Inflammation
affiliations.

Volume 2 Issue 3 (2024) 1 doi: 10.36922/jcbp.2381