Page 23 - JCBP-2-4

Journal of Clinical and

Basic Psychosomatics

ORIGINAL RESEARCH ARTICLE
Exploring the role of genetic factors in

personality disorders among women with
heroin dependence

Kadir Uludag* , Hang Su, Haifeng Jiang, Na Zhong, Jiang Du ,
and Min Zhao
Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai,
China

Abstract
Heroin dependence is a severe psychiatric issue that often coexists with mood
disorders and personality disorders, which further compound the complexity
and severity of the dependence. The utilization of genetic factors in predicting
psychiatric disorders has made notable advancements. We enrolled female patients
diagnosed with heroin dependence (n = 263) and assessed individuals with paranoid
personality disorder, depressive personality disorder, antisocial personality disorder,
and schizoid personality disorder based on the DSM-IV criteria. Our objective was
to examine the single nucleotide polymorphisms (SNPs; rs174696, rs174699, rs4680,
rs4818, rs737866, rs933271, rs12953076b, and rs44458044b) and their association
with personality. We discovered a significant association of antisocial personality
disorder with rs1544325, rs4680, and rs4818 (P < 0.05). Additionally, hallucinogen
*Corresponding author: use was associated with rs3792738 (P < 0.05), rs10062367 (P < 0.05), and rs1875999
Kadir Uludag (P < 0.01). However, we did not observe a relationship between the SNPs and schizoid
(kadiruludag@mails.ucas.ac.cn)
personality disorder, paranoid personality disorder, or depressive personality disorder.
Citation: Uludag K, Su H, Jiang H, Heroin dependence is linked to specific personality disorders, particularly antisocial
Zhong N, Du J, Zhao M. Exploring
the role of genetic factors in personality disorder. The influence of genetic factors could have a significant impact
personality disorders among women on the emergence of personality alterations linked to the consumption of heroin.
with heroin dependence. J Clin
Basic Psychosom. 2024;2(4):3890.
doi: 10.36922/jcbp.3890 Keywords: Heroin dependence; Heroin dependence treatment; Drug addiction;
Received: June 7, 2024 Psychotic disorder; Personality disorder; Hallucinogen use; Antisocial personality disorder
Accepted: July 22, 2024
Published Online: October 4, 2024
1. Introduction
Copyright: © 2024 Author(s).
This is an Open-Access article The abuse or dependence on heroin is a widespread and frequently encountered
distributed under the terms of the
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1
Creative Commons Attribution issue, and it associated with negative mood states, cardiovascular problems, poor
License, permitting distribution, oral health, cognitive impairment, accelerated aging, impulsivity, experimentally-
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and reproduction in any medium, induced aggressiveness, and impaired behavior. The health-related quality of life is
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provided the original work is
properly cited. negatively impacted in Asian individuals who use heroin and report experiencing
psychopathological symptoms. 10
Publisher’s Note: AccScience
Publishing remains neutral with The consumption of heroin can potentially lead to alterations in one’s personality, while
regard to jurisdictional claims in 11
published maps and institutional individuals with specific personality traits such as positive urgency may be inclined to
affiliations. engage in heroin use. Individuals possessing positive urgency may have a higher likelihood
Volume 2 Issue 4 (2024) 1 doi: 10.36922/jcbp.3890