Page 26 - JCBP-2-4

Journal of Clinical and
Basic Psychosomatics Genetic factors and personality disorders

Table 1. Personality disorders and genetic parameters
Paranoid personality Depressive Antisocial personality Schizotypal Hallucinogen Alcohol use
disorder personality disorder disorder personality disorder use
rs1544325 P>0.05 P>0.05 P<0.05; P>0.05 P>0.05 P>0.05
χ : 12.082
2
φ: 0.131
rs174696 p>0.05 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05
rs4680 P>0.05 P>0.05 P<0.05; P>0.05 P>0.05 P>0.05
χ : 10.460
2
φ: 0.124
rs4818 P>0.05 P>0.05 P<0.05; P>0.05 P>0.05 P>0.05
2
χ : 9.601
φ: 0.117
rs933271 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05
rs737866 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05
rs12953076 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05
rs4458044 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05
rs242924 P>0.05 P>0.05 P<0.05; P>0.05 P>0.05 P>0.05
2
χ : 9.202
φ: 0.112
rs17689966 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05
rs3792738 P>0.05 P>0.05 P>0.05 P>0.05 P<0.05; P>0.05
χ : 7.875
2
φ: 0.104
rs1715751 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05
rs32897 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05 P>0.05
rs10062367 P>0.05 P>0.05 P>0.05 P>0.05 P<0.05, P>0.05
χ : 9.342
2
φ: 0.113
rs1875999 P>0.05 P>0.05 P>0.05 P>0.05 P<0.01; P>0.05
χ :13.147
2
φ: 0.135

(P > 0.05). However, a correlation was observed between
antisocial personality disorder and schizotypal personality
disorder (P < 0.05, r = 0.150) as well as between antisocial
personality disorder and paranoid personality disorder
(P < 0.01, r = 0.187).
After controlling for the impact of schizoid personality
disorder, a weak but significant correlation (P < 0.05,
r = 0.124) was found between depressive and paranoid
personality disorder. However, when also considering the
influence of antisocial personality disorder in addition to Figure 2. A summary of the main subjects overviewed in the current
work
schizoid, the correlation between depressive and paranoid
personality disorder was not found to be significant related to stress and COMT. Our analysis revealed a significant
(P > 0.05). Figure 2 presents a visual summary or overview
of theis work. association between antisocial personality disorder and the
following SNPs: rs1544325 (χ : 12.082), rs4680 (χ : 10.460),
2
2
4. Discussion rs4818 (χ : 9.601), and rs242924 (χ :9.202).
2
2
The main findings of the study indicated that specific Furthermore, hallucinogen use was associated with
personality disorders may be associated with genetic factors rs3792738 (P < 0.05), rs10062367 (P < 0.05), and rs1875999

Volume 2 Issue 4 (2024) 4 doi: 10.36922/jcbp.3890