Page 29 - JCBP-2-4

Journal of Clinical and
Basic Psychosomatics Genetic factors and personality disorders

research specifically focusing on paranoid personality as a neural basis for impulsive-antisocial behavior and
and heroin comorbidity is limited, there are several substance abuse in individuals with psychopathy. The
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factors to consider. Paranoia can be associated with COMT gene’s impact on dopamine mechanism can have
certain substance abuses, such as the use of cocaine and implications for antisocial personality traits, potentially
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methamphetamine. However, the literature on paranoid accounting for notable differences observed among
personality disorder and heroin use is limited. individuals with different COMT variants.
Additionally, we observed no association between 4.3.4. Depressive personality disorder
genetic factors and paranoid personality disorder in
females with heroin dependence. The literature is scarce on the relationship depressive
personality disorder and genetics in individuals with
4.3.3. Antisocial personality disorder and heroin heroin dependence. Patients with personality disorders
had a higher frequency of previous depressive episodes.
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A previous study claimed that heroin dependence is in Depression increases the risk of developing substance use
high degree in comorbidity with antisocial personality disorders. Furthermore, a previous study claimed that in
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disorder. Antisocial personality disorder is a personality heroin-dependent individuals, higher levels of depression
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disorder characterized by a pervasive pattern of was correlated with higher levels of psychoticism and
disregard for and violation of the rights of others. Heroin neuroticism. 67
dependence, on the other hand, is a substance use
disorder involving a compulsive and harmful dependence While there is limited research specifically examining
on heroin. the relationship between depressive personality disorder
and heroin dependence, there are some connections
Antisocial personality disorder and heroin dependence between the two considering self-medication hypothesis
are two distinct yet interconnected mental health and vulnerability to addiction. In general, our research
conditions that can significantly impact an individual’s revealed no significant genetic factors (e.g., COMT)
quality of life. Another study found that psychopathy may associated with depressive personality disorder.
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exacerbate decision-making deficits in heroin dependent
individuals. The association between 5-HTTVNTR The current literature lacks sufficient evidence on the
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and DATVNTR interactions may be linked to the relationship between depressive personality disorder
co-occurrence of antisocial personality disorder in male and genetics in heroin-dependent individuals. However,
patients dependent on heroin. 57 patients with personality disorders have been found to
have a higher frequency of previous depressive episodes,
Antisocial personality disorder is associated with increased and depression itself has been linked to an increased risk
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psychiatric problems and criminal activities. Hence, it is of developing substance use disorders.
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crucial to comprehend the interconnection between heroin
use and crime, as well as the causal relationship between the 5. Conclusion
two.
In individuals with heroin dependence, COMT SNPs are
Overall, we found that antisocial personality associated with the development of personality changes,
disorder is associated with following SNPs: rs1544325 including antisocial personality disorder. Genetic factors,
(χ : 12.082), rs4680 (χ : 10.460), rs4818 (χ : 9.601), and however, were not found to be linked with other personality
2
2
2
rs242924 (χ : 9.202). Additionally, rs242924 is related to disorders, such as paranoid personality disorder, depressive
2
corticotropin-releasing hormone, a neuropeptide that personality disorder, and schizotypal personality disorder,
plays a crucial role in response to stress. 60 under investigation.
In addition, a previous study offers additional evidence 5.1. Limitations
supporting the involvement of the COMT gene as a
modifier that influences the variation between individuals The current study has several significant methodological
in their inclination towards violent behavior, specifically limitations. Firstly, due to its cross-sectional nature, it is
in subjects without significant mental disorders. challenging to determine the temporal sequence between
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Moreover, the role of COMT is to facilitate the breakdown the variables. Consequently, we cannot establish whether
of catecholamines-like dopamine. The chronic use of the variables preceded or followed the symptoms.
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addictive drugs (e.g., heroin) can lead to a reduction in the Moreover, a substantial portion of the data relied on
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expression of dopamine receptors in the brain. Moreover, self-reported measures (personality scale results), which
the hyperreactivity of the dopaminergic reward system at introduce a risk of biased self-presentation. It is important
the neurochemical and neurophysiological levels can serve to acknowledge that personality is a complex construct,

Volume 2 Issue 4 (2024) 7 doi: 10.36922/jcbp.3890