Page 98 - JCTR-11-2

Journal of Clinical and
Translational Research Biomimetic matrix used to treat diabetic foot ulcers

which require thawing and/or additional manipulation Funding
such as cutting to size, rehydrating, or reconstituting, the
BMM delivery system is ready to use and easy to apply. None.
Historically, other biomaterials used in wound Conflict of interest
management do not address some of the most critical factors The authors declare no conflict of interest.
to achieving wound closure. Collagen-based materials, for
instance, provide a substrate for cellular migration and Author contributions
proliferation and may help reduce enzymatic degradation
but do not control bioburden and are, in fact, prone to Conceptualization: Adam Landsman
microbial colonization. Living cell materials have been Investigation: All authors
13
shown to stimulate wound healing by introducing growth Methodology: Adam Landsman
factors in addition to an ECM, but they also fail to reduce Writing – original draft: All authors
bioburden during the healing process and are constrained Writing – review & editing: All authors
by other limitations including low cell survival post- Ethics approval and consent to participant
delivery or even adverse events such as immunogenicity.
This work has been approved by Massachusetts General
BMM mimics the native ECM, which is critical in Brigham IRB, Protocol #2025P000269.
supporting cellular infiltration and revascularization
while also functioning as an antibacterial barrier to Consent for publication
contamination. The specifically designed delivery system
enables precise application and intimate contact of the Not applicable.
BMM with the wound bed, including hard-to-reach areas, Availability of data
and therefore eliminates dead space. The self-stable, sterile,
ready, and easy-to-use system makes it a convenient Data is available from the corresponding author upon
product across different wound care settings. The fact that reasonable request.
the matrix is resorbable and fully integrated with the tissue
is also beneficial, as it does not require product removal at References
dressing changes, which could disrupt the newly developed 1. Darwin E, Tomic-Canic M. Healing chronic wounds:
tissue and delay the healing process. BMM was uniquely Current challenges and potential solutions. Curr Dermatol
designed to address the specific clinical needs of a chronic Rep. 2018;7(4):296-302.
wound and to address the shortcomings of other treatment doi: 10.1007/s13671-018-0239-4
options.
2. Vecin NM, Kirsner RS. Skin substitutes as treatment for
5. Conclusion chronic wounds: Current and future directions. Front Med
(Lausanne). 2023;10:1154567.
In this small case series, we explored the use of BMM, a
novel class of self-assembling peptide-based biomaterial doi: 10.3389/fmed.2023.1154567
for wound care. The findings demonstrate that BMM 3. Singh AV, Chandrasekar V, Prabhu VM, et al. Sustainable
treatment rapidly reduced wound area, improved overall bioinspired materials for regenerative medicine:
appearance, and reduced the depth of complex diabetic Balancing toxicology, environmental impact, and ethical
lower extremity wounds. Considering the limitations of a considerations. Biomed Mater. 2024;19(6):1-17.
case series, it is important to note that this study lacks the doi: 10.1088/1748-605X/ad85bb
statistical rigor and appropriate methodology to support 4. Haines LA, Rajagopal K, Ozbas B, Salick DA, Pochan DJ,
BMM’s efficacy. However, these results provide insights Schneider JP. Light-activated hydrogel formation via the
into the potential use of this innovative product to treat triggered folding and self-assembly of a designed peptide.
and manage complex chronic wounds. Further studies, J Am Chem Soc. 2005;127:17025-17029.
preferably randomized clinical trials, are needed to validate doi: 10.1021/ja054719o
and expand the findings from this study.
5. Jafari A. Advancements in self-assembling peptides:
Acknowledgments Bridging gaps in 3D cell culture and electronic device
fabrication. J Biomater Appl. 2024;38(10):1013-1035.
The authors would like to thank Ana Tellechea, Brunno
Caetano, Manav Mehta, Daljit Kaur, and Rebecca Salamone doi: 10.1177/08853282241240139
for their help and guidance with this study. 6. La Manna S, Di Natale C, Onesto V, Marasco D. Self-

Volume 11 Issue 2 (2025) 92 doi: 10.36922/jctr.24.00063