Page 70 - JCTR-11-5

Journal of Clinical and
Translational Research Metabolism of healthy and leukemic stem cells

doi: 10.3389/fcell.2020.599276 doi: 10.3748/wjg.v27.i40.6908
54. Yu M, Qin K, Fan J, et al. The evolving roles of Wnt signaling in 66. Lane AN, Fan TW. Regulation of mammalian nucleotide
stem cell proliferation and differentiation, the development metabolism and biosynthesis. Nucleic Acids Res.
of human diseases, and therapeutic opportunities. Genes 2015;43(4):2466-2485.
Dis. 2024;11(3):101026.
doi: 10.1093/nar/gkv047
doi: 10.1016/j.gendis.2023.04.042
67. Chandel NS. Lipid metabolism. Cold Spring Harb Perspect
55. Evans AG, Calvi LM. Notch signaling in the malignant bone Biol. 2021;13(9):a040576.
marrow microenvironment: Implications for a niche-based
model of oncogenesis. Ann N Y Acad Sci. 2015;1335(1):63-77. doi: 10.1101/cshperspect.a040576
68. Chandel NS. Carbohydrate metabolism. Cold Spring Harb
doi: 10.1111/nyas.12562
Perspect Biol. 2021;13(1):a040568.
56. Ge Y, Wang J, Zhang H, Li J, Ye M, Jin X. Fate of hematopoietic
stem cells determined by notch1 signaling (review). Exp doi: 10.1101/cshperspect.a040568
Ther Med. 2022;23(2):170. 69. Mohrin M, Shin J, Liu Y, et al. Stem cell aging. A mitochondrial
UPR-mediated metabolic checkpoint regulates hematopoietic
doi: 10.3892/etm.2021.11093
stem cell aging. Science. 2015;347(6228):1374-1377.
57. Chen J, Sun Y, Chi Z. Regulation of hematopoiesis by
hedgehog signaling (review). Mol Med Rep. 2023;27(5):100. doi: 10.1126/science.aaa2361
doi: 10.3892/mmr.2023.12987 70. Lin YF, Haynes CM. Metabolism and the UPR(mt). Mol Cell.
2016;61(5):677-682.
58. Cain CJ, Manilay JO. Hematopoietic stem cell fate decisions
are regulated by Wnt antagonists: Comparisons and current doi: 10.1016/j.molcel.2016.02.004
controversies. Exp Hematol. 2013;41(1):3-16. 71. Ocampo A, Izpisua Belmonte JC. Stem cells. Holding your
doi: 10.1016/j.exphem.2012.09.006 breath for longevity. Science. 2015;347(6228):1319-1320.
59. Merchant A, Joseph G, Wang Q, Brennan S, Matsui W. Gli1 doi: 10.1126/science.aaa9608
regulates the proliferation and differentiation of HSCs and 72. Vannini N, Girotra M, Naveiras O, et al. Specification
myeloid progenitors. Blood. 2010;115(12):2391-2396. of haematopoietic stem cell fate via modulation of
doi: 10.1182/blood-2009-09-241703 mitochondrial activity. Nat Commun. 2016;7:13125.
60. Chandel NS. Glycolysis. Cold Spring Harb Perspect Biol. doi: 10.1038/ncomms13125
2021;13(5):a040535. 73. Houten SM, Wanders RJ. A general introduction to the
doi: 10.1101/cshperspect.a040535 biochemistry of mitochondrial fatty acid β-oxidation.
J Inherit Metab Dis. 2010;33(5):469-477.
61. Spencer JA, Ferraro F, Roussakis E, et al. Direct measurement
of local oxygen concentration in the bone marrow of live doi: 10.1007/s10545-010-9061-2
animals. Nature. 2014;508(7495):269-273. 74. Ito K, Carracedo A, Weiss D, et al. A PML-PPAR-δ pathway
doi: 10.1038/nature13034 for fatty acid oxidation regulates hematopoietic stem cell
maintenance. Nat Med. 2012;18(9):1350-1358.
62. Cullen SC, Cook EV. Normal human arterial oxygen tension.
Am J Physiol Legacy Content. 1942;137(1):238-241. doi: 10.1038/nm.2882
doi: 10.1152/ajplegacy.1942.137.1.238 75. Bonora M, Morganti C, Van Gastel N, et al. A mitochondrial
NADPH-cholesterol axis regulates extracellular vesicle
63. Takubo K, Goda N, Yamada W, et al. Regulation of the HIF- biogenesis to support hematopoietic stem cell fate. Cell Stem
1alpha level is essential for hematopoietic stem cells. Cell Cell. 2024;31(3):359-377.e10.
Stem Cell. 2010;7(3):391-402.
doi: 10.1016/j.stem.2024.02.004
doi: 10.1016/j.stem.2010.06.020
76. Tiwari SK, Toshniwal AG, Mandal S, Mandal L. Fatty
64. Du J, Chen Y, Li Q, et al. HIF-1α deletion partially rescues acid β-oxidation is required for the differentiation of
defects of hematopoietic stem cell quiescence caused by larval hematopoietic progenitors in Drosophila. Elife.
cited2 deficiency. Blood. 2012;119(12):2789-2798.
2020;9:e53247.
doi: 10.1182/blood-2011-10-387902
doi: 10.7554/eLife.53247
65. Zhou MY, Cheng ML, Huang T, et al. Transforming growth
factor beta-1 upregulates glucose transporter 1 and glycolysis 77. Jackson BT, Finley LWS. Metabolic regulation of the hallmarks
through canonical and noncanonical pathways in hepatic of stem cell biology. Cell Stem Cell. 2024;31(2):161-180.
stellate cells. World J Gastroenterol. 2021;27(40):6908-6926. doi: 10.1016/j.stem.2024.01.003

Volume 11 Issue 5 (2025) 64 doi: 10.36922/JCTR025320053