Page 99 - JCTR-11-5

Journal of Clinical and
Translational Research ROCK inhibition in chronic rejection

Writing – original draft: Malgorzata Kloc, Arijita Subuddhi, doi: 10.1007/978-3-319-54090-0_15
Marta Halasa 7. Liu Y, Chen W, Wu C, et al. Macrophage/monocyte-
Writing – review & editing: Malgorzata Kloc, Souhail A. specific deletion of Ras homolog gene family member A
Thabet, Rafik M. Ghobrial (RhoA) downregulates fractalkine receptor and inhibits
chronic rejection of mouse cardiac allografts. J Heart Lung
Ethics approval and consent to participate Transplant. 2017;36:340-354.
All experiments were performed according to The doi: 10.1016/j.healun.2016.08.011
Methodist Hospital Research Institute animal care and use 8. Chen W, Chen W, Chen S, Uosef A, Ghobrial RM, Kloc M.
standards, as outlined in the Guide for the Care and Use of Fingolimod (FTY720) prevents chronic rejection of rodent
Laboratory Animals (DHHS publication No. [NIH] 85-23 cardiac allografts through inhibition of the RhoA pathway.
Revised 1985). The Institute also mandates concordance Transpl Immunol. 2021;65:101347.
with the Public Health Service Policy on Humane Care and doi: 10.1016/j.trim.2020.101347
Use of Laboratory Animals and the National Institute of
Health Principles for the Utilization and Care of Vertebrate 9. Tharaux PL, Bukoski RC, Rocha PN, et al. Rho kinase promotes
Animals Used in Testing, Research, and Training. The use of alloimmune responses by regulating the proliferation and
structure of T cells. J Immunol. 2003;171:96-105.
mice was approved by The Houston Methodist Research
Institute Institutional Animal Care and Use Committee doi: 10.4049/jimmunol.171.1.96
(IACUC; Protocol number #S00007095). 10. Subuddhi A, Uosef A, Zou D, Ubelaker HV, Ghobrial RM,
Kloc M. Comparative transcriptome profile of mouse
Consent for publication macrophages treated with the RhoA/Rock pathway inhibitors
Not applicable. Y27632, fingolimod (gilenya), and rezurock (belumosudil,
SLx-2119). Int Immunopharmacol. 2023;118:110017.
Availability of data doi: 10.1016/j.intimp.2023.110017
Data from this study are available from the corresponding 11. Liu Y, Chen W, Minze LJ, et al. Dissonant response of M0/
author on reasonable request. M2 and M1 bone-marrow-derived macrophages to RhoA
pathway interference. Cell Tissue Res. 2016;366:707-720.
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Volume 11 Issue 5 (2025) 93 doi: 10.36922/JCTR025270036