Page 100 - JCTR-11-5

Journal of Clinical and
Translational Research ROCK inhibition in chronic rejection

Immunol. 2021;230:108823. doi: 10.1002/path.2277
doi: 10.1016/j.clim.2021.108823 28. Wells RG. How collagen becomes ‘stiff’. Elife. 2022;11:e77041.
17. Ogawa T, Shichino S, Ueha S, Matsushima K. Macrophages doi: 10.7554/eLife.77041
in lung fibrosis. Int Immunol. 2021;33:665-671.
29. Pardali E, Sanchez-Duffhues G, Gomez-Puerto MC,
doi: 10.1093/intimm/dxab040 Ten Dijke P. TGF-β-induced endothelial-mesenchymal
transition in fibrotic diseases. Int J Mol Sci. 2017;18:2157.
18. Reyfman PA, Walter JM, Joshi N, et al. Single-cell
transcriptomic analysis of human lung provides insights doi: 10.3390/ijms18102157
into the pathobiology of pulmonary fibrosis. Am J Respir 30. Biernacka A, Dobaczewski M, Frangogiannis NG. TGF-β
Crit Care Med. 2019;199:1517-1536.
signaling in fibrosis. Growth Factors. 2011;29:196-202.
doi: 10.1164/rccm.201712-2410OC
doi: 10.3109/08977194.2011.595714
19. Yue Z, Jiang Z, Ruan B, et al. Disruption of myofibroblastic 31. Chang DH, Youn JC, Dilibero D, Patel JK, Kobashigawa JA.
notch signaling attenuates liver fibrosis by modulating Heart transplant immunosuppression strategies at cedars-
fibrosis progression and regression. Int J Biol Sci. sinai medical center. Int J Heart Fail. 2020;3:15-30.
2021;17:2135-2146.
doi: 10.36628/ijhf.2020.0034
doi: 10.7150/ijbs.60056
32. Hardinger KL, Brennan DC. Novel immunosuppressive
20. D’Amati A, Ronca R, Maccarinelli F, et al. PTX3 shapes agents in kidney transplantation. World J Transplant.
profibrotic immune cells and epithelial/fibroblast repair 2013;3:68-77.
and regeneration in a murine model of pulmonary fibrosis.
Pathol Res Pract. 2023;251:154901. doi: 10.5500/wjt.v3.i4.68
doi: 10.1016/j.prp.2023.154901 33. Small B, Au J, Brink H, Shah I, Strah H. Induction and
maintenance immunosuppression in lung transplantation.
21. Han X, Liu L, Huang S, et al. RNA m6A methylation
modulates airway inflammation in allergic asthma via Indian J Thorac Cardiovasc Surg. 2022;38(Suppl 2):300-317.
PTX3-dependent macrophage homeostasis. Nat Commun. doi: 10.1007/s12055-021-01225-x
2023;14:7328.
34. Moini M, Schilsky ML, Tichy EM. Review on
doi: 10.1038/s41467-023-43219-w immunosuppression in liver transplantation. World J
Hepatol. 2015;7:1355-1368.
22. Raghu H, Lepus CM, Wang Q, et al. CCL2/CCR2, but
not CCL5/CCR5, mediates monocyte recruitment, doi: 10.4254/wjh.v7.i10.1355
inflammation and cartilage destruction in osteoarthritis. 35. Safarini OA, Keshavamurthy C, Patel P. Calcineurin
Ann Rheum Dis. 2017;76:914-922.
inhibitors. In: StatPearls. Treasure Island, FL: StatPearls
doi: 10.1136/annrheumdis-2016-210426 Publishing; 2025.
23. Sahin H, Wasmuth HE. Chemokines in tissue fibrosis. 36. Allison AC, Eugui EM. Mycophenolate mofetil and its
Biochim Biophys Acta. 2013;1832:1041-1048. mechanisms of action. Immunopharmacology. 2000;47:85-118.
doi: 10.1016/j.bbadis.2012.11.004 doi: 10.1016/s0162-3109(00)00188-0
24. Yang J, Agarwal M, Ling S, et al. Diverse injury pathways 37. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M.
induce alveolar epithelial cell CCL2/12, which promotes Immunosuppression by glucocorticoids: Inhibition of
lung fibrosis. Am J Respir Cell Mol Biol. 2020;62:622-632. NF-kappa B activity through induction of I kappa B
synthesis. Science. 1995;270:286-290.
doi: 10.1165/rcmb.2019-0297OC
doi: 10.1126/science.270.5234.286
25. Palchevskiy V, Hashemi N, Weigt SS, et al. Immune
response CC chemokines CCL2 and CCL5 are associated 38. Wu K, Wang JP, Natekar NA, et al. Roadmap on magnetic
with pulmonary sarcoidosis. Fibrogenesis Tissue Repair. nanoparticles in nanomedicine. Nanotechnology.
2011;4:10. 2024;36(4):042003.
doi: 10.1186/1755-1536-4-10 doi: 10.1088/1361-6528/ad8626
26. Seki E, De Minicis S, Inokuchi S, et al. CCR2 promotes 39. Singh R, Yadav D, Ingole PG, Ahn YH. Magnetic engineering
hepatic fibrosis in mice. Hepatology. 2009;50:185-197. nanoparticles: Versatile tools revolutionizing biomedical
applications. Biomater Adv. 2024;163:213948.
doi: 10.1002/hep.22952
doi: 10.1016/j.bioadv.2024.213948
27. Wynn TA. Cellular and molecular mechanisms of fibrosis.
J Pathol. 2008;214:199-210. 40. Mishra S, Yadav MD. Magnetic nanoparticles:

Volume 11 Issue 5 (2025) 94 doi: 10.36922/JCTR025270036