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386 Miyake et al. | Journal of Clinical and Translational Research 2023; 9(6): 381-391
Table 2. Comparison of baseline characteristics according to response to neoadjuvant chemotherapy in patients with yielding pathological T2≤ and/or
N+ urothelial carcinoma
Variables Down‑staged ypT2≤ No‑changed ypT2≤ Up‑staged ypT2≤ P‑value
N (%) 14 (100%) 39 (100%) 42 (100%) -
Age (years-old), mean±standard deviation 69.4±6.8 68.3±10.5 70.2±9.4 0.66
Sex
Male 13 (93%) 25 (64%) 35 (83%) 0.037
Female 1 (7.1%) 14 (36%) 7 (17%)
ECOG-PS
0 13 (93%) 32 (82%) 32 (76%) 0.52
1 1 (7.1%) 6 (15%) 5 (12%)
2 0 0 2 (4.8%)
Unknown 0 1 (2.6%) 3 (7.1%)
Multiplicity
Single 12 (86%) 28 (72%) 25 (60%) 0.29
Multiple 2 (14%) 10 (26%) 13 (31%)
Unknown 0 1 (2.6%) 4 (9.5%)
Clinical T category
cT1 0 0 6 (14%) # 0.004
cT2 0 12 (31%) 13 (31%)
cT3 10 (71%) 20 (51%) 14 (33%)
cT4 4 (29%) 7 (18%) 3 (7.1%)
Unknown 0 0 6 (14%) ##
Clinical N category
cN0 13 (93%) 23 (59%) 39 (93%) 0.003
cN+ 1 (7.1) 16 (31%) 3 (7.1%)
NAC regimen
GC 9 (64%) 30 (77%) 21 (50%) 0.16
MVAC 2 (14%) 3 (7.7%) 6 (14%)
Others 3 (21%) 6 (15%) 15 (36%)
The number of NAC cycles
2 or less 8 (57%) 22 (56%) 23 (55%) 0.72
3 4 (29%) 14 (36%) 10 (24%)
4 1 (7.1%) 1 (2.6%) 4 (9.5%)
5 or more 0 1 (2.6%) 3 (7.1%)
Unknown 1 (7.1) 1 (2.6%) 2 (4.8%)
Pathological T category
ypTis 0 0 1 (2.4%) <0.001
ypT1 0 0 5 (12%)
ypT2 11 (79%) 12 (31%) 5 (12%)
ypT3 3 (21%) 20 (51%) 24 (57%)
ypT4 0 7 (18%) 7 (17%)
Pathological N category
ypN0 14 (100%) 28 (72%) 15 (36%) <0.001
ypN+ 0 11 (28%) 27 (64%)
CIS
No 11 (79%) 31 (80%) 38 (91%) 0.1
Yes 2 (14%) 8 (20%) 4 (9.5)
Unknown 1 (7.1%) 0 0
LVI
No 6 (42.9) 17 (43.6) 18 (42.9) 0.87
Yes 8 (57.1) 22 (56.4) 23 (54.8)
Unknown 0 0 1 (2.4) 0.24
Variant histology
No 14 (100%) 38 (97%) 38 (91%)
Yes 0 1 (2.6%) 4 (9.5%)
CIS: Carcinoma in situ; ECOG-PS, Eastern Cooperative Oncology Group-performance status; LVI, lymphovascular invasion; NAC, neoadjuvant chemotherapy Of six patients with cT1
#
##
UTUC, two had ypT2 ypN0 and the remaining four had ypN+in the nephroureterectomy specimens after NAC; All six patients with unknown cT UTUC had ypN+in the nephroureterectomy
specimens after NAC
DOI: http://dx.doi.org/10.18053/jctres.09.202306.23-00106