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Malakar et al. | Journal of Clinical and Translational Research 2023; 9(6): 423-432 427
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Figure 2. Long non-coding RNAs (lncRNAs) and autophagy as possible therapeutic targets of selinexor. (A) This schematic provides an overview
of the potential therapeutic targeting of long non-coding RNAs (lncRNAs) by selinexor. It also illustrates the regulation and implications of altered
lncRNA expression in acute lymphoblastic leukemia (ALL). (B) This diagram outlines the role of autophagy in the selinexor-mediated response in
ALL. It emphasizes the significance of autophagy in ALL. The “???” in the figure symbolizes areas that remain unexplored or unanswered.

isoforms that are unique to cancer and display either absence governing alternative splicing regulation [52]. Alternative splicing
or distinctive expression levels when contrasted with their plays a pivotal role in enhancing the intricacy of proteins within the
equivalents in healthy tissue [50]. Significantly, a considerable human system [34]. This intricate process is under the regulation
proportion of these transcripts encompass pivotal oncogenes of splicing factors [49,53], which exert control over alternative
and tumor suppressor genes [50,51]. Among the proteins that splicing. It is evident that a strong correlation exists between
are translocated to the nucleus in selinexor-sensitive cells, there numerous diseases and the disruptions and errors in splicing
was a notable over-presentation of KEGG terms associated with regulation caused by these splicing factors [50,51,53]. These
spliceosome [13]. The spliceosome holds a significant function in crucial regulatory elements, known as splicing factors, belong to

DOI: http://dx.doi.org/10.18053/jctres.09.202306.23-00088