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Microbes & Immunity Factors associated with response to T-VEC

Table 3. Patient characteristics and disease failure‑free Table 3. (Continued)
survival
Variable Recurrence P‑value
Variable Recurrence P‑value (%)
(%) Prior immunotherapy
Categorical variables a Yes 38 1.00
Total 39 No 40
Sex Number of prior lines of
Male 36 1.00 immunotherapy
Female 43 0 40 0.22
Race 1 27
Caucasian 39 2 100
Other - Concurrent
immunotherapy and
Breslow categorical
T-VEC
<1 mm 33 0.18 Yes 31 0.33
1.01 – 2 mm 0
No 60
2.01 – 4 mm 100
Infield response (complete
>4 mm 33 or partial)
Stage at T-VEC initiation Yes 29 0.25
IIIB 0 0.31 No 75
IIIC 33 Bystander response
IIID 0 Yes 33 0.01
IV 67 No 83
BRAF mutation N/A 11
Mutant 80 0.05 Continuous variables a Recurrence No recurrence
Wild-type 23 (Mean [SD]) (Mean [SD])
NRAS mutation Age at T-VEC injections 77 (8) 69 (10) 0.97
(years)
Mutant 29 0.64
Breslow depth (mm) 4.8 (3.4) 5.4 (4.0) 0.73
Wild-type 45
Number of cycles of T-VEC 5.1 (2.9) 7.2 (4.0) 0.26
Injection location
Note: Fisher’s exact tests for categorical variables, two-sample t-tests
a
Head and neck 33 1.00 for continuous variables.
Upper extremity 67 0.53 Abbreviation: T-VEC: Talimogene laherparepvec.
Torso 40 1.00
Lower extremity 25 0.37 OS. However, a higher Breslow category (2.01 – 4.00 mm)
Type of lesion injected exhibited a trend toward worse OS (P = 0.06). Similarly,
Skin 67 0.53 a higher stage at the initiation of T-VEC injections also
Soft tissue 38 1.00 trended toward increased mortality, with all three deaths
Lymph node 50 1.00 observed in stage IV patients. Conversely, factors such
Number of treated lesions as the anatomic site of injection, type of lesion injected,
1 38 1.00 and number of lesions injected did not demonstrate any
association with OS. Prior systemic and immunotherapy
2 44 did not exhibit a significant association with OS; however,
≥3 0 having ≥2 prior lines of immunotherapy was associated
Prior systemic therapy with worse OS (P = 0.006) (Table 4 and Figure 1C).
Yes 38 1.00 Furthermore, a statistically significant relationship was
No 40
identified between the absence of a bystander response and
(Cont'd...) the mortality rate (P = 0.05) (Table 4).

Volume 1 Issue 1 (2024) 100 doi: 10.36922/mi.3445