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Microbes & Immunity Neurological and cranial involvement in SAPHO syndrome

adalimumab further supports the possibility of a headache 2. Tsugawa J, Ouma S, Fukae J, Tsuboi Y. Recurrent unilateral
secondary to a systemic inflammatory process associated headache associated with SAPHO syndrome. Intern Med.
with the spectrum of SAPHO syndrome. 2014;53:1559-1562.
doi: 10.2169/internalmedicine.53.2150
4. Conclusion
3. Dihlmann W, Dihlmann WS, Hering L. Acquired
The current case report presents an atypical intracranial hyperostosis syndrome - AHYS - (sternocostoclavicular
involvement tied to the inflammatory process inherent in hyperostosis, pustulotic arthro-osteitis, SAPHO-syndrome):
SAPHO syndrome through a well documentation of the Bone scintigraphy of the anterior chest wall. Clin Rheumatol.
syndrome’s distinctive imaging and analytical features. 1997;16:13-24.
These findings underscore the importance of considering doi: 10.1007/BF02238758
systemic inflammatory disorders in the differential 4. Benhamou CL, Enjolras O, Delrieu F, Prier A, Camus JP,
diagnosis of headaches. Amor B. Pseudoseptic arthritis and bacterid of Andrews.

Acknowledgments Rev Rhum Mal Osteoartic. 1984;51:229-231.
5. Furer V, Kishimoto M, Tsuji S, et al. The diagnosis and
None. treatment of adult patients with SAPHO syndrome:
Controversies revealed in a multidisciplinary international
Funding survey of physicians. Rheumatol Ther. 2020;7:883-891.
None. doi: 10.1007/s40744-020-00235-2

Conflict of interest 6. Yildirim DT, Sari İ. SAPHO syndrome: Current clinical,
diagnostic and treatment approaches. Rheumatol Int.
E. Santos is on the advisory board for Biogen, Genzyme, 2023;44:2301-2313.
Bayer, Merck, Alexion, and Novartis, and has received doi: 10.1007/s00296-023-05491-3
a grant from Roche. The authors certify that there is no
conflict of interest regarding the publication of this paper. 7. Dantas RLF, Dantas F, Mourão GDNTR, Mattos CB,
Fonseca DTKV. Synovitis, acne, pustulosis, hyperostosis,
Author contributions osteitis (SAPHO) syndrome mimicking bone metastases in
the spine: A presentation of two cases and literature review.
Conceptualization: All authors Cureus. 2024;16:e64974.
Investigation: All authors doi: 10.7759/cureus.64974
Methodology: All authors
Writing – original draft: João Moura 8. Duan N, Chen X, Liu Y, Wang J, Wang Z. Multimodal
Writing – review & editing: All authors imaging findings of SAPHO syndrome with no skin lesions:
A report of three cases and review of the literature. Exp Ther
Ethical approval and consent to participate Med. 2016;12:2665-2670.

No ethical approval was required. Informed consent was doi: 10.3892/etm.2016.3689
taken from the patient before participation. 9. Diprose KW, Jordan A, Anderson EN. Autoinflammatory
syndromes in neurology: When our first line of defence
Consent for publication misbehaves. Pract Neurol. 2022;22:145-153.
Written informed consent for publishing was obtained by doi: 10.1136/practneurol-2021-003031
the patient. 10. Castillo DFJ, Caniego T, Hurtado-Nédélec M, et al.
THU0466 unraveling the genetic basis of familial SAPHO
Availability of data syndrome with next-generation sequencing. Ann Rheum
Not applicable. Dis. 2014;73:344.
11. Ferguson JP, Lokuta AM, El‐Shanti IH, Muhle L, Bing X,
References Huttenlocher A. Neutrophil dysfunction in a family with
a SAPHO syndrome-like phenotype. Arthritis Rheum.
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