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Microbes & Immunity                                                PTMs in Sepsis: Mechanisms and therapy



               inflammation by activating the PI3K/Akt pathway.  Oxid   2016;26(4):399-422.
               Med Cell Longev. 2020;2020:1720961.
                                                                  doi: 10.1038/cr.2016.39
               doi: 10.1155/2020/1720961
                                                               70.  Shao S, Zhou D, Feng J, et al. Regulation of inflammation
            60.  Liang LD, Peng HX, Huang MJ,  et al. HGF ameliorates   and immunity in sepsis by E3 ligases.  Front Endocrinol
               cardiomyocyte apoptosis and inflammatory response in   (Lausanne). 2023;14:1124334.
               sepsis via the phosphatidylinositol 3-kinase (PI3K)/protein      doi: 10.3389/fendo.2023.1124334
               kinase B (AKT) pathway. Gene. 2024;928:148763.
                                                               71.  Shim DW, Lee KH. Posttranslational regulation of the NLR
               doi: 10.1016/j.gene.2024.148763
                                                                  family pyrin domain-containing 3 inflammasome.  Front
            61.  Zhao Y, Ye W, Wang YD, Chen WD. HGF/c-met:       Immunol. 2018;9:1054.
               A  key promoter in liver regeneration.  Front  Pharmacol.      doi: 10.3389/fimmu.2018.01054
               2022;13:808855.
                                                               72.  Toldo S, Mezzaroma E, Buckley LF, et al. Targeting the NLRP3
               doi: 10.3389/fphar.2022.808855
                                                                  inflammasome in cardiovascular diseases. Pharmacol Ther.
            62.  Ziegler AC, Haider RS, Hoffmann C, Gräler MH. S1PR3   2022;236:108053.
               agonism and S1P lyase inhibition rescue mice in the      doi: 10.1016/j.pharmthera.2021.108053
               severe state of experimental sepsis. Biomed Pharmacother.
               2024;174:116575.                                73.  Tang J, Tu S, Lin G, et al. Sequential ubiquitination of NLRP3
                                                                  by RNF125 and Cbl-b limits inflammasome activation and
               doi: 10.1016/j.biopha.2024.116575
                                                                  endotoxemia. J Exp Med. 2020;217(4):133674.
            63.  Wang L, Jiang S, Li X, Lin T, Qin T. Astringin protects
               LPS-induced toxicity by suppressing oxidative stress and      doi: 10.1084/jem.20182091
               inflammation via suppression of PI3K/AKT/NF-κB pathway   74.  Wang  D,  Zhang  Y,  Xu  X,  et  al.  YAP  promotes  the
               for pediatric acute lung injury. Naunyn Schmiedebergs Arch   activation of NLRP3 inflammasome via blocking K27-
               Pharmacol. 2023;396(10):2369-2377.                 linked polyubiquitination of NLRP3.  Nat  Commun.
                                                                  2021;12(1):2674.
               doi: 10.1007/s00210-023-02439-z
                                                                  doi: 10.1038/s41467-021-22987-3
            64.  Zheng Y, Li Y, Li S, Hu R, Zhang L. Annexin A1 (Ac2-26)-
               dependent Fpr2 receptor alleviates sepsis-induced acute   75.  Shen  W, Zhang  X, Tang  M, Chen W,  Wang Y, Zhou  H.
               kidney injury by inhibiting inflammation and apoptosis in   Targeting of ubiquitination and degradation of KLF15 by
               vivo and in vitro. Inflamm Res. 2023;72(2):347-362.  E3 ubiquitin ligase KBTBD7 regulates LPS-induced septic
                                                                  brain injury in microglia. Exp Cell Res. 2024;443(1):114317.
               doi: 10.1007/s00011-022-01640-9
                                                                  doi: 10.1016/j.yexcr.2024.114317
            65.  Ng YY, Ho YC, Yen CH, et al. Protective Effect of hibifolin
               on  lipopolysaccharide-induced  acute  lung  injury  through   76.  Liu J, Song K, Lin B,  et  al. The suppression of HSPA8
               akt phosphorylation and NFκB pathway.  Environ Toxicol.   attenuates NLRP3 ubiquitination through SKP2 to promote
               2024;40:524-531.                                   pyroptosis in sepsis-induced lung injury.  Cell Biosci.
                                                                  2024;14(1):56
               doi: 10.1002/tox.24383
                                                                  doi: 10.1186/s13578-024-01239-z
            66.  Tang AL, Li Y, Sun LC, et al. Xuebijing improves intestinal
               microcirculation dysfunction in septic rats by regulating the   77.  Xu D, Jiang J, Liu Y, et al. TIMP2 protects against
               VEGF-A/PI3K/Akt signaling pathway. World J Emerg Med.   sepsis-associated acute kidney injury by cAMP/NLRP3
               2024;15(3):206-213.                                axis-mediated pyroptosis.  Am J Physiol Cell Physiol.
                                                                  2024;326(5):C1353-C1366.
               doi: 10.5847/wjem.j.1920-8642.2024.035
                                                                  doi: 10.1152/ajpcell.00577.2023
            67.  Kawamura A, Ito A, Takahashi A, Sawamoto A, Okuyama  S,
               Nakajima M. Benproperine reduces IL-6 levels via Akt   78.  Cockram PE, Kist M, Prakash S, Chen SH, Wertz IE,
               signaling in monocyte/macrophage-lineage cells and   Vucic D. Ubiquitination in the regulation of inflammatory
               reduces the mortality of mouse sepsis model induced by   cell death and cancer. Cell Death Differ. 2021;28(2):591-605.
               lipopolysaccharide. J Pharmacol Sci. 2024;156(2):125-133.
                                                                  doi: 10.1038/s41418-020-00708-5
               doi: 10.1016/j.jphs.2024.08.001
                                                               79.  Wang  Y,  Chen  D,  Xie  H,  et al.  AUF1  protects  against
            68.  Popovic D, Vucic D, Dikic I. Ubiquitination in disease   ferroptosis to alleviate sepsis-induced acute lung injury by
               pathogenesis and treatment. Nat Med. 2014;20(11):1242-1253.  regulating NRF2 and ATF3. Cell Mol Life Sci. 2022;79(5):228.
               doi: 10.1038/nm.3739                               doi: 10.1007/s00018-022-04248-8
            69.  Swatek KN, Komander D. Ubiquitin modifications. Cell Res.   80.  Li Z, Wu B, Chen J, et al. WWP2 protects against sepsis-


            Volume 2 Issue 3 (2025)                         12                           doi: 10.36922/MI025090016
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