Page 20 - MI-2-3
P. 20
Microbes & Immunity PTMs in Sepsis: Mechanisms and therapy
inflammation by activating the PI3K/Akt pathway. Oxid 2016;26(4):399-422.
Med Cell Longev. 2020;2020:1720961.
doi: 10.1038/cr.2016.39
doi: 10.1155/2020/1720961
70. Shao S, Zhou D, Feng J, et al. Regulation of inflammation
60. Liang LD, Peng HX, Huang MJ, et al. HGF ameliorates and immunity in sepsis by E3 ligases. Front Endocrinol
cardiomyocyte apoptosis and inflammatory response in (Lausanne). 2023;14:1124334.
sepsis via the phosphatidylinositol 3-kinase (PI3K)/protein doi: 10.3389/fendo.2023.1124334
kinase B (AKT) pathway. Gene. 2024;928:148763.
71. Shim DW, Lee KH. Posttranslational regulation of the NLR
doi: 10.1016/j.gene.2024.148763
family pyrin domain-containing 3 inflammasome. Front
61. Zhao Y, Ye W, Wang YD, Chen WD. HGF/c-met: Immunol. 2018;9:1054.
A key promoter in liver regeneration. Front Pharmacol. doi: 10.3389/fimmu.2018.01054
2022;13:808855.
72. Toldo S, Mezzaroma E, Buckley LF, et al. Targeting the NLRP3
doi: 10.3389/fphar.2022.808855
inflammasome in cardiovascular diseases. Pharmacol Ther.
62. Ziegler AC, Haider RS, Hoffmann C, Gräler MH. S1PR3 2022;236:108053.
agonism and S1P lyase inhibition rescue mice in the doi: 10.1016/j.pharmthera.2021.108053
severe state of experimental sepsis. Biomed Pharmacother.
2024;174:116575. 73. Tang J, Tu S, Lin G, et al. Sequential ubiquitination of NLRP3
by RNF125 and Cbl-b limits inflammasome activation and
doi: 10.1016/j.biopha.2024.116575
endotoxemia. J Exp Med. 2020;217(4):133674.
63. Wang L, Jiang S, Li X, Lin T, Qin T. Astringin protects
LPS-induced toxicity by suppressing oxidative stress and doi: 10.1084/jem.20182091
inflammation via suppression of PI3K/AKT/NF-κB pathway 74. Wang D, Zhang Y, Xu X, et al. YAP promotes the
for pediatric acute lung injury. Naunyn Schmiedebergs Arch activation of NLRP3 inflammasome via blocking K27-
Pharmacol. 2023;396(10):2369-2377. linked polyubiquitination of NLRP3. Nat Commun.
2021;12(1):2674.
doi: 10.1007/s00210-023-02439-z
doi: 10.1038/s41467-021-22987-3
64. Zheng Y, Li Y, Li S, Hu R, Zhang L. Annexin A1 (Ac2-26)-
dependent Fpr2 receptor alleviates sepsis-induced acute 75. Shen W, Zhang X, Tang M, Chen W, Wang Y, Zhou H.
kidney injury by inhibiting inflammation and apoptosis in Targeting of ubiquitination and degradation of KLF15 by
vivo and in vitro. Inflamm Res. 2023;72(2):347-362. E3 ubiquitin ligase KBTBD7 regulates LPS-induced septic
brain injury in microglia. Exp Cell Res. 2024;443(1):114317.
doi: 10.1007/s00011-022-01640-9
doi: 10.1016/j.yexcr.2024.114317
65. Ng YY, Ho YC, Yen CH, et al. Protective Effect of hibifolin
on lipopolysaccharide-induced acute lung injury through 76. Liu J, Song K, Lin B, et al. The suppression of HSPA8
akt phosphorylation and NFκB pathway. Environ Toxicol. attenuates NLRP3 ubiquitination through SKP2 to promote
2024;40:524-531. pyroptosis in sepsis-induced lung injury. Cell Biosci.
2024;14(1):56
doi: 10.1002/tox.24383
doi: 10.1186/s13578-024-01239-z
66. Tang AL, Li Y, Sun LC, et al. Xuebijing improves intestinal
microcirculation dysfunction in septic rats by regulating the 77. Xu D, Jiang J, Liu Y, et al. TIMP2 protects against
VEGF-A/PI3K/Akt signaling pathway. World J Emerg Med. sepsis-associated acute kidney injury by cAMP/NLRP3
2024;15(3):206-213. axis-mediated pyroptosis. Am J Physiol Cell Physiol.
2024;326(5):C1353-C1366.
doi: 10.5847/wjem.j.1920-8642.2024.035
doi: 10.1152/ajpcell.00577.2023
67. Kawamura A, Ito A, Takahashi A, Sawamoto A, Okuyama S,
Nakajima M. Benproperine reduces IL-6 levels via Akt 78. Cockram PE, Kist M, Prakash S, Chen SH, Wertz IE,
signaling in monocyte/macrophage-lineage cells and Vucic D. Ubiquitination in the regulation of inflammatory
reduces the mortality of mouse sepsis model induced by cell death and cancer. Cell Death Differ. 2021;28(2):591-605.
lipopolysaccharide. J Pharmacol Sci. 2024;156(2):125-133.
doi: 10.1038/s41418-020-00708-5
doi: 10.1016/j.jphs.2024.08.001
79. Wang Y, Chen D, Xie H, et al. AUF1 protects against
68. Popovic D, Vucic D, Dikic I. Ubiquitination in disease ferroptosis to alleviate sepsis-induced acute lung injury by
pathogenesis and treatment. Nat Med. 2014;20(11):1242-1253. regulating NRF2 and ATF3. Cell Mol Life Sci. 2022;79(5):228.
doi: 10.1038/nm.3739 doi: 10.1007/s00018-022-04248-8
69. Swatek KN, Komander D. Ubiquitin modifications. Cell Res. 80. Li Z, Wu B, Chen J, et al. WWP2 protects against sepsis-
Volume 2 Issue 3 (2025) 12 doi: 10.36922/MI025090016

