Page 18 - MI-2-3
P. 18
Microbes & Immunity PTMs in Sepsis: Mechanisms and therapy
Immunol. 2022;13:956361. 28. Zeng N, Jian Z, Zhu W, Xu J, Fan Y, Xiao F. KLF13
overexpression protects sepsis-induced myocardial injury
doi: 10.3389/fimmu.2022.956361
and LPS-induced inflammation and apoptosis. Int J Exp
18. Deng S, Gu B, Yu Z, Shen Z, Ren H. MIR210HG aggravates Pathol. 2023;104(1):23-32.
sepsis-induced inflammatory response of proximal tubular
epithelial cell via the NF-κB Signaling pathway. Yonsei Med doi: 10.1111/iep.12459
J. 2021;62(5):461-469. 29. Huang X, Zhang MZ, Liu B, Ma SY, Yin X, Guo LH.
doi: 10.3349/ymj.2021.62.5.461 Astragaloside IV attenuates polymicrobial sepsis-induced
cardiac dysfunction in rats via IKK/NF-κB pathway. Chin J
19. Wu JL, Wu HY, Tsai DY, et al. Temporal regulation of Lsp1 Integr Med. 2021;27(11):825-831.
O-GlcNAcylation and phosphorylation during apoptosis of
activated B cells. Nat Commun. 2016;7:12526. doi: 10.1007/s11655-021-2869-9
doi: 10.1038/ncomms12526 30. Huang Q, Liu DH, Chen CF, et al. Pgc-1α promotes
phosphorylation, inflammation, and apoptosis in H9c2 cells
20. Qian Y, Wang Z, Lin H, et al. TRIM47 is a novel endothelial during the early stage of lipopolysaccharide induction.
activation factor that aggravates lipopolysaccharide-induced Inflammation. 2021;44(5):1771-1781.
acute lung injury in mice via K63-linked ubiquitination of
TRAF2. Signal Transduct Target Ther. 2022;7(1):148. doi: 10.1007/s10753-021-01453-8
doi: 10.1038/s41392-022-00953-9 31. Li H, Liu Z, Wang Y, et al. PARK7 is induced to protect
against endotoxic acute kidney injury by suppressing
21. An S, Yao Y, Hu H, et al. PDHA1 hyperacetylation- NF-κB. Clin Sci (Lond). 2022;136(24):1877-1891.
mediated lactate overproduction promotes sepsis-induced
acute kidney injury via Fis1 lactylation. Cell Death Dis. doi: 10.1042/CS20220493
2023;14(7):457. 32. Cargnello M, Roux PP. Activation and function of the
doi: 10.1038/s41419-023-05952-4 MAPKs and their substrates, the MAPK-activated protein
kinases. Microbiol Mol Biol Rev. 2011;75(1):50-83.
22. Singh V, Ram M, Kumar R, Prasad R, Roy BK, Singh KK.
Phosphorylation: Implications in Cancer. Protein J. doi: 10.1128/MMBR.00031-10
2017;36(1):1-6. 33. Park HB, Baek KH. E3 ligases and deubiquitinating enzymes
doi: 10.1007/s10930-017-9696-z regulating the MAPK signaling pathway in cancers. Biochim
Biophys Acta Rev Cancer. 2022;1877(3):188736.
23. Yu H, Lin L, Zhang Z, Zhang H, Hu H. Targeting NF-κB
pathway for the therapy of diseases: Mechanism and clinical doi: 10.1016/j.bbcan.2022.188736
study. Signal Transduct Target Ther. 2020;5(1):209. 34. Lucas RM, Luo L, Stow JL. ERK1/2 in immune signalling.
doi: 10.1038/s41392-020-00312-6 Biochem Soc Trans. 2022;50(5):1341-1352.
24. Lai JL, Liu YH, Liu C, et al. Indirubin inhibits LPS-induced doi: 10.1042/BST20220271
inflammation via TLR4 abrogation mediated by the NF-kB and 35. Crawford TQ, Hecht FM, Pilcher CD, Ndhlovu LC,
MAPK signaling pathways. Inflammation. 2017;40(1):1-12. Barbour JD. Activation associated ERK1/2 signaling
+
doi: 10.1007/s10753-016-0447-7 impairments in CD8 T cells co-localize with blunted
polyclonal and HIV-1 specific effector functions in early
25. Zhou X, Zhang L, Lie L, et al. MxA suppresses TAK1-IKKα/ untreated HIV-1 infection. PLoS One. 2013;8(10):e77412.
β-NF-κB mediated inflammatory cytokine production to
facilitate Mycobacterium tuberculosis infection. J Infect. doi: 10.1371/journal.pone.0077412
2020;81(2):231-241. 36. Liang D, Zeng Q, Xu Z, et al. BAFF activates Erk1/2
+
doi: 10.1016/j.jinf.2020.05.030 promoting cell proliferation and survival by Ca2 -CaMKII-
dependent inhibition of PP2A in normal and neoplastic
26. Yuan M, Jing G, Kong Q, et al. TIPE2 ameliorates B-lymphoid cells. Biochem Pharmacol. 2014;87(2):332-343.
neuroinflammation and cognitive impairment in sepsis-
associated encephalopathy through regulating RhoA/ doi: 10.1016/j.bcp.2013.11.006
ROCK2-NF-κB signaling pathway. Biochem Pharmacol. 37. Feng Z, Li M, Ma A, et al. Intermedin
2023;217:115816. (adrenomedullin 2) plays a protective role in sepsis by
doi: 10.1016/j.bcp.2023.115816 regulating T- and B-cell proliferation and activity. Int
Immunopharmacol. 2023;121:110488.
27. Duan M, Jie J, Li C, et al. Echinatin alleviates sepsis severity
through modulation of the NF-κB and MEK/ERK signaling doi: 10.1016/j.intimp.2023.110488
pathways. Biomed Pharmacother. 2024;179:117359.
38. Yuan Y, Hua L, Zhou J, et al. The effect of artesunate to
doi: 10.1016/j.biopha.2024.117359 reverse CLP-induced sepsis immunosuppression mice
Volume 2 Issue 3 (2025) 10 doi: 10.36922/MI025090016

