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Microbes & Immunity                                                PTMs in Sepsis: Mechanisms and therapy



               Immunol. 2022;13:956361.                        28.  Zeng N, Jian Z, Zhu W, Xu J, Fan Y, Xiao F. KLF13
                                                                  overexpression protects sepsis-induced myocardial injury
               doi: 10.3389/fimmu.2022.956361
                                                                  and LPS-induced inflammation and apoptosis.  Int J Exp
            18.  Deng S, Gu B, Yu Z, Shen Z, Ren H. MIR210HG aggravates   Pathol. 2023;104(1):23-32.
               sepsis-induced inflammatory response of proximal tubular
               epithelial cell via the NF-κB Signaling pathway. Yonsei Med      doi: 10.1111/iep.12459
               J. 2021;62(5):461-469.                          29.  Huang X, Zhang MZ, Liu B, Ma SY, Yin X, Guo LH.
               doi: 10.3349/ymj.2021.62.5.461                     Astragaloside  IV attenuates polymicrobial sepsis-induced
                                                                  cardiac dysfunction in rats via IKK/NF-κB pathway. Chin J
            19.  Wu JL, Wu HY, Tsai DY, et al. Temporal regulation of Lsp1   Integr Med. 2021;27(11):825-831.
               O-GlcNAcylation and phosphorylation during apoptosis of
               activated B cells. Nat Commun. 2016;7:12526.       doi: 10.1007/s11655-021-2869-9
               doi: 10.1038/ncomms12526                        30.  Huang  Q,  Liu  DH,  Chen  CF,  et al.  Pgc-1α  promotes
                                                                  phosphorylation, inflammation, and apoptosis in H9c2 cells
            20.  Qian Y, Wang Z, Lin H, et al. TRIM47 is a novel endothelial   during the early stage of lipopolysaccharide induction.
               activation factor that aggravates lipopolysaccharide-induced   Inflammation. 2021;44(5):1771-1781.
               acute lung injury in mice via K63-linked ubiquitination of
               TRAF2. Signal Transduct Target Ther. 2022;7(1):148.     doi: 10.1007/s10753-021-01453-8
               doi: 10.1038/s41392-022-00953-9                 31.  Li  H,  Liu  Z,  Wang  Y,  et al.  PARK7  is  induced  to  protect
                                                                  against endotoxic acute kidney injury by suppressing
            21.  An S, Yao Y, Hu H,  et al. PDHA1 hyperacetylation-  NF-κB. Clin Sci (Lond). 2022;136(24):1877-1891.
               mediated lactate overproduction promotes sepsis-induced
               acute kidney injury via Fis1 lactylation.  Cell  Death Dis.      doi: 10.1042/CS20220493
               2023;14(7):457.                                 32.  Cargnello M, Roux PP. Activation and function of the
               doi: 10.1038/s41419-023-05952-4                    MAPKs and their substrates, the MAPK-activated protein
                                                                  kinases. Microbiol Mol Biol Rev. 2011;75(1):50-83.
            22.  Singh V, Ram M, Kumar R, Prasad R, Roy BK, Singh KK.
               Phosphorylation: Implications in Cancer.  Protein J.      doi: 10.1128/MMBR.00031-10
               2017;36(1):1-6.                                 33.  Park HB, Baek KH. E3 ligases and deubiquitinating enzymes
               doi: 10.1007/s10930-017-9696-z                     regulating the MAPK signaling pathway in cancers. Biochim
                                                                  Biophys Acta Rev Cancer. 2022;1877(3):188736.
            23.  Yu H, Lin L, Zhang Z, Zhang H, Hu H. Targeting NF-κB
               pathway for the therapy of diseases: Mechanism and clinical      doi: 10.1016/j.bbcan.2022.188736
               study. Signal Transduct Target Ther. 2020;5(1):209.  34.  Lucas RM, Luo L, Stow JL. ERK1/2 in immune signalling.
               doi: 10.1038/s41392-020-00312-6                    Biochem Soc Trans. 2022;50(5):1341-1352.
            24.  Lai JL, Liu YH, Liu C, et al. Indirubin inhibits LPS-induced      doi: 10.1042/BST20220271
               inflammation via TLR4 abrogation mediated by the NF-kB and   35.  Crawford TQ, Hecht FM, Pilcher CD, Ndhlovu LC,
               MAPK signaling pathways. Inflammation. 2017;40(1):1-12.  Barbour  JD. Activation associated ERK1/2 signaling
                                                                                   +
               doi: 10.1007/s10753-016-0447-7                     impairments  in  CD8   T  cells  co-localize  with  blunted
                                                                  polyclonal and HIV-1 specific effector functions in early
            25.  Zhou X, Zhang L, Lie L, et al. MxA suppresses TAK1-IKKα/  untreated HIV-1 infection. PLoS One. 2013;8(10):e77412.
               β-NF-κB mediated inflammatory cytokine production to
               facilitate  Mycobacterium tuberculosis  infection.  J  Infect.      doi: 10.1371/journal.pone.0077412
               2020;81(2):231-241.                             36.  Liang D, Zeng Q, Xu Z,  et al. BAFF activates Erk1/2
                                                                                                     +
               doi: 10.1016/j.jinf.2020.05.030                    promoting cell proliferation and survival by Ca2 -CaMKII-
                                                                  dependent inhibition of PP2A in normal and neoplastic
            26.  Yuan M, Jing G, Kong Q,  et  al. TIPE2 ameliorates   B-lymphoid cells. Biochem Pharmacol. 2014;87(2):332-343.
               neuroinflammation and cognitive impairment in sepsis-
               associated encephalopathy through regulating RhoA/     doi: 10.1016/j.bcp.2013.11.006
               ROCK2-NF-κB signaling pathway.  Biochem Pharmacol.   37.  Feng  Z,  Li  M,  Ma  A,  et  al.  Intermedin
               2023;217:115816.                                   (adrenomedullin  2) plays  a protective  role  in sepsis  by
               doi: 10.1016/j.bcp.2023.115816                     regulating T-  and B-cell proliferation and activity.  Int
                                                                  Immunopharmacol. 2023;121:110488.
            27.  Duan M, Jie J, Li C, et al. Echinatin alleviates sepsis severity
               through modulation of the NF-κB and MEK/ERK signaling      doi: 10.1016/j.intimp.2023.110488
               pathways. Biomed Pharmacother. 2024;179:117359.
                                                               38.  Yuan Y, Hua L, Zhou J,  et al. The effect of artesunate to
               doi: 10.1016/j.biopha.2024.117359                  reverse CLP-induced sepsis immunosuppression mice


            Volume 2 Issue 3 (2025)                         10                           doi: 10.36922/MI025090016
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