Page 19 - MI-2-3

Microbes & Immunity PTMs in Sepsis: Mechanisms and therapy

with secondary infection is tightly related to reducing the 48. Wang Y, Cui C, Zhao W, et al. WIP1-mediated regulation
apoptosis of T cells via decreasing the inhibiting receptors of p38 MAPK signaling attenuates pyroptosis in
and activating MAPK/ERK pathway. Int Immunopharmacol. sepsis-associated acute kidney injury. Immunobiology.
2023;124(Pt A):110917. 2024;229(5):152832.
doi: 10.1016/j.intimp.2023.110917 doi: 10.1016/j.imbio.2024.152832
39. Hammouda MB, Ford AE, Liu Y, Zhang JY. The JNK 49. Hillmer EJ, Zhang H, Li HS, Watowich SS. STAT3 signaling
signaling pathway in inflammatory skin disorders and in immunity. Cytokine Growth Factor Rev. 2016;31:1-15.
cancer. Cells. 2020;9(4):857. doi: 10.1016/j.cytogfr.2016.05.001
doi: 10.3390/cells9040857 50. Lei W, Liu D, Sun M, et al. Targeting STAT3: A crucial
40. Zhu H, Zhang L, Jia H, et al. Tetrahydrocurcumin improves modulator of sepsis. J Cell Physiol. 2021;236(11):7814-7831.
lipopolysaccharide-induced myocardial dysfunction by doi: 10.1002/jcp.30394
inhibiting oxidative stress and inflammation via JNK/
ERK signaling pathway regulation. Phytomedicine. 51. Paul WE, Zhu J. How are T(H)2-type immune responses
2022;104:154283. initiated and amplified? Nat Rev Immunol. 2010;10(4):225-235.
doi: 10.1016/j.phymed.2022.154283 doi: 10.1038/nri2735
41. Ouyang J, Hong Y, Wan Y, et al. PVB exerts anti-inflammatory 52. Liu Y, Yang H, Zhu F, Ouyang Y, Pan P. Inhibition of
effects by inhibiting the activation of MAPK and NF-κB STAT3 phosphorylation by colchicine regulates NLRP3
signaling pathways and ROS generation in neutrophils. Int activation to alleviate sepsis-induced acute lung injury.
Immunopharmacol. 2024;126:111271. Inflammopharmacology. 2023;31(4):2007-2021.
doi: 10.1016/j.intimp.2023.111271 doi: 10.1007/s10787-023-01199-9
42. Coulthard LR, White DE, Jones DL, McDermott MF, 53. Qian T, Qi B, Fei Y, et al. PLD2 deletion alleviates disruption
Burchill SA. p38(MAPK): Stress responses from of tight junctions in sepsis-induced ALI by regulating PA/
molecular mechanisms to therapeutics. Trends Mol Med. STAT3 phosphorylation pathway. Int Immunopharmacol.
2009;15(8):369-379. 2023;114:109561.
doi: 10.1016/j.molmed.2009.06.005 doi: 10.1016/j.intimp.2022.109561
43. Dai M, Sun S, Dai Y, et al. Maresin-1 ameliorates sepsis- 54. Li N, Lin G, Zhang H, et al. Lyn attenuates sepsis-associated
induced microglial activation through modulation of the acute kidney injury by inhibition of phospho-STAT3 and
P38 MAPK pathway. Neurochem Res. 2024;50(1):26. apoptosis. Biochem Pharmacol. 2023;211:115523.
doi: 10.1007/s11064-024-04280-z doi: 10.1016/j.bcp.2023.115523
44. Zhang HF, Zhang HB, Wu XP, Guo YL, Cheng WD, Qian F. 55. Tan Z, Liu Q, Chen H, et al. Pectolinarigenin alleviated
Fisetin alleviates sepsis-induced multiple organ dysfunction septic acute kidney injury via inhibiting Jak2/Stat3 signaling
in mice via inhibiting p38 MAPK/MK2 signaling. Acta and mitochondria dysfunction. Biomed Pharmacother.
Pharmacol Sin. 2020;41(10):1348-1356. 2023;159:114286.
doi: 10.1038/s41401-020-0462-y doi: 10.1016/j.biopha.2023.114286
45. Dong R, Xue Z, Fan G, et al. Pin1 promotes NLRP3 56. Xu L, Cai J, Li C, et al. 4-Octyl itaconate attenuates LPS-
inflammasome activation by phosphorylation of p38 MAPK induced acute kidney injury by activating Nrf2 and
pathway in septic shock. Front Immunol. 2021;12:620238. inhibiting STAT3 signaling. Mol Med. 2023;29(1):58.
doi: 10.1186/s10020-023-00631-8
doi: 10.3389/fimmu.2021.620238
46. Li D, Ren W, Jiang Z, Zhu L. Regulation of the NLRP3 57. Wang L, Deng Z, Sun Y, et al. The study on the regulation of
inflammasome and macrophage pyroptosis by the p38 Th cells by mesenchymal stem cells through the JAK-STAT
MAPK signaling pathway in a mouse model of acute lung signaling pathway to protect naturally aged sepsis model
injury. Mol Med Rep. 2018;18(5):4399-4409. rats. Front Immunol. 2022;13:820685.
doi: 10.3389/fimmu.2022.820685
doi: 10.3892/mmr.2018.9427
58. Ersahin T, Tuncbag N, Cetin-Atalay R. The PI3K/AKT/mTOR
47. Yue L, Liu X, Wu C, et al. Toll-like receptor 4 promotes
the inflammatory response in septic acute kidney injury interactive pathway. Mol Biosyst. 2015;11(7):1946-1954.
by promoting p38 mitogen-activated protein kinase doi: 10.1039/c5mb00101c
phosphorylation. J Bioenerg Biomembr. 2023;55(5):353-363.
59. Liu H, Weng XJ, Yao JY, et al. Neuregulin-1 β protects the
doi: 10.1007/s10863-023-09972-9 rat diaphragm during sepsis against oxidative stress and

Volume 2 Issue 3 (2025) 11 doi: 10.36922/MI025090016