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Microbes & Immunity                                                PTMs in Sepsis: Mechanisms and therapy



               Menaquinone-4 alleviates sepsis-associated acute lung   acute kidney injury. Adv Sci (Weinh). 2024;11(28):e2307216.
               injury via activating SIRT3-p53/SLC7A11 pathway.      doi: 10.1002/advs.202307216
               J Inflamm Res. 2024;17:7675-7685.
                                                               108. Gong F, Zheng X, Xu W, et al. H3K14la drives endothelial
               doi: 10.2147/JIR.S486984                           dysfunction  in  sepsis-induced  ARDS  by  promoting
            102. Guo J, Yuan Z, Wang R. Zn  improves sepsis-induced   SLC40A1/transferrin-mediated ferroptosis.  MedComm
                                      2+
               acute kidney injury by upregulating SIRT7-mediated   (2020). 2025;6(2):e70049.
               parkin acetylation.  Am J Physiol Renal Physiol.      doi: 10.1002/mco2.70049
               2024;327(1):F184-F197.
                                                               109. Yang K, Fan M, Wang X, et al. Lactate promotes macrophage
               doi: 10.1152/ajprenal.00337.2023                   HMGB1 lactylation, acetylation, and exosomal release in
            103. Zhang D, Tang Z, Huang H,  et al. Metabolic regulation   polymicrobial sepsis. Cell Death Differ. 2022;29(1):133-146.
               of  gene  expression  by histone  lactylation.  Nature.      doi: 10.1038/s41418-021-00841-9
               2019;574(7779):575-580.
                                                               110. Sun Z, Song Y, Li J, Li Y, Yu Y, Wang X. Potential biomarker
               doi: 10.1038/s41586-019-1678-1                     for  diagnosis  and  therapy  of  sepsis:  Lactylation.  Immun
            104. Liu S, Yang T, Jiang Q, et al. Lactate and lactylation in sepsis:   Inflamm Dis. 2023;11(10):e1042.
               A comprehensive review. J Inflamm Res. 2024;17:4405-4417.     doi: 10.1002/iid3.1042
               doi: 10.2147/JIR.S459185                        111. Liu  Z,  Ting  Y,  Li  M,  Li  Y,  Tan  Y,  Long  Y.  From  immune
            105. Wu D, Spencer CB, Ortoga L, Zhang H, Miao C. Histone   dysregulation to organ dysfunction: Understanding the
               lactylation-regulated METTL3 promotes ferroptosis via   enigma of Sepsis. Front Microbiol. 2024;15:1415274.
               m6A-modification on ACSL4 in sepsis-associated lung      doi: 10.3389/fmicb.2024.1415274
               injury. Redox Biol. 2024;74:103194.
                                                               112. Wu X, Xu M, Geng M, et al. Targeting protein modifications
               doi: 10.1016/j.redox.2024.103194                   in metabolic diseases: Molecular mechanisms and targeted
            106. Lu Z, Fang P, Li S,  et al. Lactylation of histone H3k18   therapies. Signal Transduct Target Ther. 2023;8(1):220.
               and Egr1 promotes endothelial glycocalyx degradation      doi: 10.1038/s41392-023-01439-y
               in sepsis-induced acute lung injury.  Adv Sci  (Weinh).   113. Yang X, Sun J, Sun F,  et  al. TRIM31 promotes apoptosis
               2024;12:e2407064.
                                                                  via TAK1-mediated activation of NF-κB signaling in
               doi: 10.1002/advs.202407064                        sepsis-induced myocardial dysfunction.  Cell Cycle.
                                                                  2020;19(20):2685-2700.
            107. Qiao J, Tan Y, Liu H,  et  al. Histone H3K18 and ezrin
               lactylation promote renal dysfunction in sepsis-associated      doi: 10.1080/15384101.2020.1826235


































            Volume 2 Issue 3 (2025)                         14                           doi: 10.36922/MI025090016
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