Page 22 - MI-2-3
P. 22
Microbes & Immunity PTMs in Sepsis: Mechanisms and therapy
Menaquinone-4 alleviates sepsis-associated acute lung acute kidney injury. Adv Sci (Weinh). 2024;11(28):e2307216.
injury via activating SIRT3-p53/SLC7A11 pathway. doi: 10.1002/advs.202307216
J Inflamm Res. 2024;17:7675-7685.
108. Gong F, Zheng X, Xu W, et al. H3K14la drives endothelial
doi: 10.2147/JIR.S486984 dysfunction in sepsis-induced ARDS by promoting
102. Guo J, Yuan Z, Wang R. Zn improves sepsis-induced SLC40A1/transferrin-mediated ferroptosis. MedComm
2+
acute kidney injury by upregulating SIRT7-mediated (2020). 2025;6(2):e70049.
parkin acetylation. Am J Physiol Renal Physiol. doi: 10.1002/mco2.70049
2024;327(1):F184-F197.
109. Yang K, Fan M, Wang X, et al. Lactate promotes macrophage
doi: 10.1152/ajprenal.00337.2023 HMGB1 lactylation, acetylation, and exosomal release in
103. Zhang D, Tang Z, Huang H, et al. Metabolic regulation polymicrobial sepsis. Cell Death Differ. 2022;29(1):133-146.
of gene expression by histone lactylation. Nature. doi: 10.1038/s41418-021-00841-9
2019;574(7779):575-580.
110. Sun Z, Song Y, Li J, Li Y, Yu Y, Wang X. Potential biomarker
doi: 10.1038/s41586-019-1678-1 for diagnosis and therapy of sepsis: Lactylation. Immun
104. Liu S, Yang T, Jiang Q, et al. Lactate and lactylation in sepsis: Inflamm Dis. 2023;11(10):e1042.
A comprehensive review. J Inflamm Res. 2024;17:4405-4417. doi: 10.1002/iid3.1042
doi: 10.2147/JIR.S459185 111. Liu Z, Ting Y, Li M, Li Y, Tan Y, Long Y. From immune
105. Wu D, Spencer CB, Ortoga L, Zhang H, Miao C. Histone dysregulation to organ dysfunction: Understanding the
lactylation-regulated METTL3 promotes ferroptosis via enigma of Sepsis. Front Microbiol. 2024;15:1415274.
m6A-modification on ACSL4 in sepsis-associated lung doi: 10.3389/fmicb.2024.1415274
injury. Redox Biol. 2024;74:103194.
112. Wu X, Xu M, Geng M, et al. Targeting protein modifications
doi: 10.1016/j.redox.2024.103194 in metabolic diseases: Molecular mechanisms and targeted
106. Lu Z, Fang P, Li S, et al. Lactylation of histone H3k18 therapies. Signal Transduct Target Ther. 2023;8(1):220.
and Egr1 promotes endothelial glycocalyx degradation doi: 10.1038/s41392-023-01439-y
in sepsis-induced acute lung injury. Adv Sci (Weinh). 113. Yang X, Sun J, Sun F, et al. TRIM31 promotes apoptosis
2024;12:e2407064.
via TAK1-mediated activation of NF-κB signaling in
doi: 10.1002/advs.202407064 sepsis-induced myocardial dysfunction. Cell Cycle.
2020;19(20):2685-2700.
107. Qiao J, Tan Y, Liu H, et al. Histone H3K18 and ezrin
lactylation promote renal dysfunction in sepsis-associated doi: 10.1080/15384101.2020.1826235
Volume 2 Issue 3 (2025) 14 doi: 10.36922/MI025090016

