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Figure 3. The trace elements with neuromodulatory and osteoinductive activities. Reprinted with permission. Copyright © 2023, Chinese Medical
101
Association.
A

B

Figure 4. NGF administration by laponite vehicles promotes CGRP secretion of neurons and osteogenic differentiation of BMSCs. (A) ELISA results
of CGRP secretion of DRG neurons with the treatment of NGF@Laponite (*P < 0.05, ** P < 0.01, ***P < 0.001). (B) Immunofluorescent labeling of
osteogenic marker Runx2 in BMSCs with the treatment of NGF@Laponite. Scale bar: 50µ. Reprinted with permission. Copyright © 2021, Wiley-VCH
113
GmbH.
Abbreviations: BMSCs: Bone marrow-derived mesenchymal stem cells; CGRP: Calcitonin gene-related peptide; DRG: Dorsal root ganglion; ELISA:
Enzyme-linked immunosorbent assay; NGF: Nerve growth factor.

deeply involved in the orchestration of peripheral nerve and dedifferentiate into a repair phenotype with excessive
regeneration and bone wound healing. 111-113 A recent factor secretion after bone injury, indicating that the
study has unveiled that the SCs can rapidly reprogram activation and maintenance of the repair SC phenotype

Volume 1 Issue 1 (2025) 8 doi: 10.36922/OR8294