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Tumor Discovery BAK1 as a novel prognostic biomarker

of liver cancer in the future, as well as new directions for References
clinical use and drug development. Our current study, 1. Niu LJ, Huang T, Wang L, et al., 2022, HBX suppresses PTEN
inevitably, has certain limitations. First, our work is based on to promote the malignant progression of hepatocellular
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5. Conclusion 3. Muhammed A, D’Alessio A, Enica A, et al., 2022, Predictive
Our data demonstrate that BAK1 expression is greatly biomarkers of response to immune checkpoint inhibitors
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expression are associated with cancer progression and
poor prognosis. These findings suggest that BAK1 may https://doi.org/10.1080/14737159.2022.2049244
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Acknowledgments
https://doi.org/10.1155/2022/5334095
We want to thank TCGA and GEO for the free access to 5. Niu Z, Xu Y, Li Y, et al., 2022, Construction and validation of
their database. a novel pyroptosis-related signature to predict prognosis in
Funding patients with cutaneous melanoma. Math Biosci Eng., 19(1):
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This work was supported by the Sanming Project of https://doi.org/10.3934/mbe.2022031
Medicine in Shenzhen (Grant no. SZSM201612021) and
the Research Foundation of Peking University Shenzhen 6. Liu X, Ding S, Liu P, 2021, The roles of gasdermin D
in coronavirus infection and evasion. Front Microbiol.,
Hospital (Grant no. JCYJ2018002).
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Conflict of interest https://doi.org/10.3389/fmicb.2021.784009
The authors declare that there are no conflicts of interest. 7. Chu Q, Jiang Y, Zhang W, et al., 2016, Pyroptosis is involved
in the pathogenesis of human hepatocellular carcinoma.
Author contributions Oncotarget, 7(51): 84658–84665.
Conceptualization: Yiyang Chen and Xi Ou https://doi.org/10.18632/oncotarget.12384
Formal analysis: Yiyang Chen and Yiju Gong 8. Yan W, Chang Y, Liang X, et al., 2012, High-mobility group
Writing – original draft: Yiyang Chen and Wanbang Zhou box 1 activates caspase-1 and promotes hepatocellular
Writing – review & editing: Yiyang Chen carcinoma invasiveness and metastases. Hepatology, 55(6):
1863–1875.
Ethics approval and consent to participate
https://doi.org/10.1002/hep.25572
This study was approved by the Ethics Committee of 9. Teng JF, Mei QB, Zhou XG, et al., 2020, Polyphyllin VI
Peking University Shenzhen Hospital. induces Caspase-1-Mediated pyroptosis via the induction of
ROS/NF-kappaB/NLRP3/GSDMD signal axis in non-small
Consent for publication cell lung cancer. Cancers (Basel) 12: 193.
Not applicable. https://doi.org/10.3390/cancers12010193

Availability of data 10. Li H, Zhao XK, Cheng YJ, et al., 2019, Gasdermin D-mediated
hepatocyte pyroptosis expands inflammatory responses
The datasets presented in this study can be found in online that aggravate acute liver failure by upregulating monocyte
repositories. The names of the repository and accession chemotactic protein 1/CC chemokine receptor-2 to recruit
number(s) can be found in the article. macrophages. World J Gastroenterol., 25: 6527–6540.

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