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Tumor Discovery LCP2 regulates melanoma progression

cytokines and chemokines to activate CD8 T lymphocytes, References
+
which finally suppressed the growth of melanoma.
1. Torre LA, Bray F, Siegel RL, et al., 2015, Global cancer
5. Conclusions statistics, 2012. CA Cancer J Clin, 65(2): 87–108.
https://doi.org/10.3322/caac.21262
LCP2 is a novel prognostic biomarker of melanoma, which
could positively regulate the IRF5 signaling pathway to 2. Schadendorf D, Fisher DE, Garbe C, et al., 2015, Melanoma.
activate tumor-infiltrating CD8 T-cells and then inhibit Nat Rev Dis Primers, 1: 15003.
+
the growth of melanoma. Nevertheless, it is important to https://doi.org/10.1038/nrdp.2015.3
point out that there are some limitations in our study. First, 3. Luke JJ, Flaherty KT, Ribas A, et al., 2017, Targeted agents
the potential association between LCP2 and IRF5 is unclear, and immunotherapies: Optimizing outcomes in melanoma.
which needs to be systematically and deeply explored Nat Rev Clin Oncol, 14(8): 463.
in vitro and in vivo. Second, more public data on melanoma https://doi.org/10.1038/nrclinonc.2017.43
patients who received immunotherapy should be included 4. Redman JM, Gibney GT, Atkins MB, 2016, Advances in
for bioinformatics analysis in this study to investigate immunotherapy for melanoma. BMC Med, 14(1): 20.
prognostic significance of LCP2 in these patients.
https://doi.org/10.1186/s12916-016-0571-0
Acknowledgments 5. D’Arcangelo D, Giampietri C, Muscio M, et al., 2018, WIPI1,

None. BAG1, and PEX3 autophagy-related genes are relevant
melanoma markers. Oxidat Med Cell Longev, 2018: 1471682.
Funding https://doi.org/10.1155/2018/1471682

This study was supported by grants from General Program, 6. Gerami P, Cook RW, Wilkinson J, et al., 2015, Development
the National Natural Science Foundation of China of a prognostic genetic signature to predict the metastatic
(No. 81874138, 82073020 and 81903222). risk associated with cutaneous melanoma. Clin Cancer Res,
21(1): 175–183.
Conflict of interest https://doi.org/10.1158/1078-0432.CCR-13-3316

The authors declare no conflicts of interest. 7. Zhao Y, Schaafsma E, Gorlov IP, et al., 2018, A leukocyte
infiltration score defined by a gene signature predicts
Author contributions melanoma patient prognosis. Mol Cancer Res, 17(1): 109filtra.

Conceptualization: Mingzhu Yin https://doi.org/10.1158/1541-7786.MCR-18-0173
Data curation: Hongyin Sun, Kui Deng 8. Clements JL, Ross-Barta SE, Tygrett LT, et al., 1998, SLP-76
Investigation: Hongyin Sun, Kui Deng expression is restricted to hemopoietic cells of monocyte,
Validation: Xingchen Zhou, Dongsheng Cao, Yan Cheng granulocyte, and T lymphocyte lineage and is regulated
Writing – original draft: Hongyin Sun, Kui Deng, Mingzhu during T cell maturation and activation. J Immunol,
Yin 161: 3880–3889.
Writing – review & editing: Xiang Chen, Mingzhu Yin 9. Jumaa H, Wollscheid B, Mitterer M, et al., 1999, Abnormal
development and function of B lymphocytes in mice
Ethics approval and consent to participate deficient for the signalling adaptor protein SLP-65.
Immunity, 11: 547–554.
All the procedures of animal study were evaluated and
approved by the Institutional Animal Care and Use https://doi.org/10.1016/s1074-7613(00)80130-2
Committee of Xiangya Hospital, Central South University 10. Zhang J, Wang L, Xu X, et al., 2020, Transcriptome-based
(No. 2022020685). network analysis unveils eight immune-related genes as
molecular signatures in the immunomodulatory subtype of
Consent for publication triple negative breast cancer. Front Oncol, 10: 1787.
https://doi.org/10.3389/fonc.2020.01787
Not applicable.
11. Huo Y, Zhang K, Han S, et al., 2021, Lymphocyte
Availability of data cytosolic protein 2 is a novel prognostic marker in lung
adenocarcinoma. J Int Med Res, 49(11): 3000605211059681.
The data used to support the findings of this study are
available from the corresponding author on reasonable https://doi.org/10.1177/03000605211059681
request. 12. Wang Z, Peng M, 2021, A novel prognostic biomarker LCP2

Volume 2 Issue 1 (2023) 11 https://doi.org/10.36922/td.308