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Tumor Discovery LCP2 regulates melanoma progression

Figure 2. Univariate survival analysis for DEGs in TCGA data set.
DEGs: Differentially expressed genes; TCGA: The Cancer Genome Atlas.

1.785 – 3.076, Figure 4A), with the median survival time of 3.4. Associations between identified prognostic
1628 and 4601 days, respectively. Meanwhile, our results genes and TAL subsets
showed that the DFS of high-risk group was significantly The associations between the selected ten prognostic genes
worse than that of low-risk group (log-rank P = 8e-07, HR:
2.895, 95% CI: 1.867 – 4.489, Figure 4B), with the median and the specific TAL were calculated using Spearman’s rank
survival time of 2195 and 6299 days, respectively. To correlation. Genes that had the largest absolute correlation
explore the robustness of ten-gene signature for predicting coefficients with certain TAL subset among all TAL
the survival of melanoma, we externally validated the subsets were considered to have strong association with
prognostic ability of ten-gene signature in an independent that TAL subset. Results showed that LCP2, ISG20, and
GSE65904 data set. Results showed that the OS of high-risk CLEC4E expression were significantly positively correlated
+
patients in GSE65904 was significantly worse than that of with CD8 T-cells. CD81 and MGRN1 expression were
low-risk patients (log-rank P = 0.0036, HR: 1.786, 95% CI: significantly positively correlated with Treg cells, while
1.202 – 2.653 days, Figure 4C), with the median survival BLNK and IL-18 expression were significantly negatively
time of 629 and 1404, respectively. In addition, patients in correlated with M0 macrophages. In addition, RAB5C and
high-risk group had significantly worse DMFS than those TRIM32 expression had strong association with B-cells
in low-risk group (log-rank P = 0.0082, HR: 1.786, 95% CI: and natural killer cells, respectively (Figure 5). Given the
1.155 – 2.762, Figure 4D), with the median survival time of important role of LCP2 in the immune system, we focused
379 and 1401 days, respectively. our efforts on investigating LCP2 in the subsequent studies.

Volume 2 Issue 1 (2023) 6 https://doi.org/10.36922/td.308