Page 49 - TD-3-1

Tumor Discovery Energy metabolism in bladder cancer

findings, normal bladder tissue, and low-grade pTa tumors Ethics approval and consent to participate
mostly rely on oxidative phosphorylation as primary
energy metabolism pathway, which contributes to high The study was conducted according to the guidelines of the
IBEC. On the other hand, high-grade pTa and high-grade Declaration of Helsinki and approved by the Institutional
pT1 tumors present prevalent glycolytic metabolism Ethics Committee of Ethics and Research Committee
profile over oxidative phosphorylation, which leads to the of Amaral Carvalho Hospital, Jaú City, São Paulo State,
lower IBEC. Brazil (CAAE number: 47475815.9.0000.5434). Informed
consent was obtained from all subjects involved in the
In conclusion, the abnormal values of IBEC observed study.
for NMIBC grades underscore its potential as a valuable
marker in both the diagnosis and prognosis of BC patients. Consent for publication
Acknowledgments Written informed consent has been obtained from the
patients to publish this paper.
The authors wish to express their gratitude for the
assistance provided by the Amaral Carvalho Hospital Availability of data
(HAC), Jaú City, São Paulo State, Brazil, and the Program The data presented in this study are available from the
in Surgery Sciences of School of Medicine, Universidade corresponding author on reasonable request.
Estadual de Campinas (UNICAMP), Campinas City, São
Paulo State, Brazil. References

Funding 1. Celada Luis G, Albers Acosta E, De la Fuente H, et al.
A comprehensive analysis of immune response in patients
This research was funded by the São Paulo Research Council with non-muscle-invasive bladder cancer. Cancers (Basel).
(FAPESP grant numbers: 2014/11866-1; 2014/12047-4; 2023;15:1364.
2018/10052-1; 2020/03419-6), and the Brazilian National doi: 10.3390/cancers15051364
Council for Scientific and Technological Development
(CNPq grant numbers: 552120/2011-1; 312396/2021-0). 2. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA,
Jemal A. Global cancer statistics 2018: GLOBOCAN
Conflict of interest estimates of incidence and mortality worldwide for 36
cancers in 185 countries. CA Cancer J Clin. 2018;68:394-424.
The authors declare that they have no competing interests.
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Böckelmann, Leandro Luiz Lopes de Freitas, João Predicting recurrence and progression in individual patients
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Karla Böckelmann, Wagner José Fávaro 7. Van Rhijn BW, Burger M, Lotan Y, et al. Recurrence and
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