Page 44 - TD-3-1

Tumor Discovery Energy metabolism in bladder cancer

A B

C D

E F

Figure 4. Representative immunoblotting analysis results and semi-quantitative determination of β-F1-ATP synthase (ATPase) (A), HADHSC (B), PDH
(C), CS (D), GLUT 1 (E), and PFK (F) protein levels. Representative protein profiles pooled from ten patients per group for each repetition (duplicate).
Graphs depict the relative expression of integrated optical density observed for β-F1-ATP synthase (ATPase), HADHSC, PDH, CS, GLUT 1, and PFK
proteins, normalized by β-actin and expressed as mean ± standard deviation. *Significance difference (P < 0.01), after applying Tukey test.
Abbreviations: ATP: Adenosine triphosphate; GLUT1: Glucose transporter-1; PFK: Phosphofructokinase; PDH: Pyruvate dehydrogenase; CS: Citrate
synthase; HADHSC: Short chain 3-hydroxyacyl-CoA dehydrogenase.

and low-grade pTa tumors recorded notably higher IBEC allows removing visible lesions and collecting tissue
values than both high-grade pTa and pT1 tumors, as samples for histopathological analysis purposes, and it
graphically represented in Figure 7. enables determining tumor stage and grade. Intravesical
chemotherapy is often administered as adjunctive measure
4. Discussion for NMIBC treatment within 6 h after TURBT to prevent

The primary treatment approach to NMIBC typically tumor cells’ post-procedure implantation and to reduce
involves surgical intervention via TURBT. This procedure relapse rates. Another adjuvant therapy option is BCG
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Volume 3 Issue 1 (2024) 8 https://doi.org/10.36922/td.2290