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Tumor Discovery RNA-protein complexes deregulated in cancer

Table 1. RNAs that inhibit gene expression through PRC2 binding and deposition of H3K27me marks
Gene Partner Target Modification Tumor References
LINC01133 EZH2, LSD1 KLF2, p21, E-cadherin H3K27me NSCLC 40
ANRIL‑CDKN2B‑AS1 PRC1–CBX7, PRC1 P14arf, p16ink4 H3K27me - 41
LL22NC03‑N64E9.1 PRC2 KLF2 H3K27me CRC 42
HOTTIP CTCF, DNMT1 MTUS1 - NSCLC 43
ARHGAP27P1 PRC2 CDKIs p15, p16 H3K27me - 44
SNHG7 PRC2 CDKIs H3K27me ovary 45
TUG1 PRC2 KLF2 H3K27me HCC 46
SNHG6 PRC2 P21, KLF2 H3K27me Osteosarcoma 47
DUXAP8 EZH2, LSD1 CDK1A, KLF2 H3K27me Pancreas 48
SNHG20 PRC2 CDKis H3K27me NSCLC 49
PVT1 EZH2 miR-200b H3K27me Cervical cancer 50,51
UCA1 PRC2 P27 H3K27me Breast cancer 52
MYLK‑AS1 PRC2 LATS2 H3K27me Gastric 53
HOXA‑AS2 EZH2, LSD1 P21, KLF2 H3K27me Colorectal 54
SNHG17 PRC2 CDKIs H3K27me Gastric 55
CHASERR, HASTER unknown Transcription factors CHD2 - Various 56
chromatin remodeler
GIHCG EZH2, DNMT1 miR-200b/a/429 H3K27me CpGme Hepatocell HCC 57
renal cell cancer
PVT1 PRC2 Apoptotic genes H3K27me MM 58
NEAT1 BRG1, SWI/SNF GADD45A Silencing GC 59
LINC00675 LSD1 SPRY4 H3K4me2 demethylated GC 57
HOXA11‑AS EZH2, LSD1, DNMT1 KLF2, PRSS8 H3K27 me3, H3K4 me - 57
demethylation
BST2/BISPR - Tetherin Positive regulator of Antiviral 57
BST2/tetherin
SNHG12 HDAC9 miR-320a downregulated Resistance to OC, Osteosarcoma 60,61
doxorubicin carboplatin
sunitinib and
temozolomide
SNHG13/DANCR KAT6A (H3K23ac), CDK inhibitors - CRC, endocrine 62
EZH2 cancers
SNHG14, SNHG15 EZH2, PRC2 - - Endocrine 63
cancers
lincRNA-CMPK2, - Block IFN response, Stop protumor Macrophage 64
NRAV/NRIR downregulate IRENA inflammatory cytokines antitumor
response
FEZF2‑AS1 LSD1 p21 H3K4me2 Gastric cancer 65
LINC0144660 LSD1 RASD1 Suppression by Gastric cancer 66
demethylating H3K4
SNHG22 EZH2 - - . 67
ATRX EZH2 Xist targets H3K27me Chromatid 68
silencing
XIST PRC2, SMRT RNA Pol II exclusion Histone deacetylation X chromosome 69
TRIM28, SHARP, silencing
HDAC3
(Cont’d...)

Volume 3 Issue 4 (2024) 6 doi: 10.36922/td.4657