Page 106 - TD-4-2

Tumor Discovery Cell-cell communication in cancer

3. Dimitrov D, Türei D, Garrido-Rodriguez M, et al. 14. Bach K, Pensa S, Zarocsinceva M, et al. Time-resolved single-
Comparison of methods and resources for cell-cell cell analysis of Brca1 associated mammary tumourigenesis
communication inference from single-cell RNA-Seq data. reveals aberrant differentiation of luminal progenitors. Nat
Nat Commun. 2022;13(1):3224. Commun. 2021;12:1502.
doi: 10.1038/s41467-022-30755-0 doi: 10.1038/s41467-021-21783-3
4. Shao X, Lu X, Liao J, Chen H, Fan X. New avenues 15. Alonso-Curbelo D, Ho YJ, Burdziak C, et al. A gene-
for systematically inferring cell-cell communication: environment-induced epigenetic program initiates
Through single-cell transcriptomics data. Protein Cell. tumorigenesis. Nature. 2021;590:642-648.
2020;11(12):866-880. doi: 10.1038/s41586-020 03147-x
doi: 10.1007/s13238-020-00727-5 16. Denk D, Greten FR. Inflammation: The incubator of the
5. Ginini L, Billan S, Fridman E, Gil Z. Insight into extracellular tumor microenvironment. Trends Cancer. 2022;8:901-914.
vesicle-cell communication: From cell recognition to doi: 10. 1016/j.trecan.2022.07.002
intracellular fate. Cells. 2022;11(9):1375.
17. Ringel AE, Drijvers JM, Baker GJ, et al. Obesity shapes
doi: 10.3390/cells11091375 metabolism in the tumor microenvironment to suppress
6. Lamouille S, Xu J, Derynck R. Molecular mechanisms of anti-tumor immunity. Cell. 2020;183:1848-1866.e26.
epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. doi: 10.1016/j.cell.2020.11.009
2014;15(3):178-196.
+
18. Philip M, Schietinger A. CD8 T cell differentiation and
doi: 10.1038/nrm3758 dysfunction in cancer. Nat Rev Immunol. 2022;22:209-223.
7. Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y, doi: 10.1038/s41577-021-00574-3
Johnson KR. Cadherin switching. J Cell Sci. 2008;121(Pt 6):
727-735. 19. Zheng L, Qin S, Si W, et al. Pan-cancer single-cell landscape
of tumor-infiltrating T cells. Science. 2021;374:abe6474.
doi: 10.1242/jcs.000455
doi: 10.1126/science.abe6474
8. Guilford P. E-cadherin downregulation in cancer: Fuel on
the fire? Mol Med Today. 1999;5(4):172-177. 20. Han C, Zhang C, Wang H, Zhao L. Exosome-mediated
communication between tumor cells and tumor-associated
doi: 10.1016/s1357-4310(99)01461-6 macrophages: Implications for tumor microenvironment.
9. Wei C, Yang C, Wang S, et al. Crosstalk between cancer Oncoimmunology. 2021;10(1):1887552.
cells and tumor associated macrophages is required for doi: 10.1080/2162402X.2021.1887552
mesenchymal circulating tumor cell-mediated colorectal
cancer metastasis. Mol Cancer. 2019;18(1):64. 21. Nicolini A, Paola F, Biava PM. Exosomes and cell
communication: From tumour-derived exosomes and their
doi: 10.1186/s12943-019-0976-4 role in tumour progression to the use of exosomal cargo for
10. Huang S, Chaudhary K, Garmire LX. More is better: Recent cancer treatment. Cancers (Basel). 2021;13(4):822.
progress in multi-omics data integration methods. Front doi: 10.3390/cancers13040822
Genet. 2017;8:84.
22. Kalluri R. The biology and function of exosomes in cancer.
doi: 10.3389/fgene.2017.00084 J Clin Invest. 2016;126(4)1208-1215.
11. Yan H, Deng X, Chen H, et al. Identification of common and doi: 10.1172/JCI81135
subtype-specific mutated sub-pathways for a cancer. Front
Genet. 2019;10:1228. 23. Kharaziha P, Ceder S, Li Q, Panaretakis T. Tumor cell-
derived exosomes: A message in a bottle. Biochim Biophys
doi: 10.3389/fgene.2019.01228 Acta. 2012;1826:103-111.
12. Griffiths JI, Cosgrove PA, Castaneda EM, et al. Cancer Cells doi: 10.1016/j.bbcan.2012.03.006
Communicate with Macrophages to Prevent T Cell Activation
During Development of Cell Cycle Therapy Resistance. 24. Nogués L, Benito-Martin A, Hergueta-Redondo M,
Peinado H. The influence of tumour-derived extracellular
BioRxiv [Preprint]; 2022.
vesicles on local and distal metastatic dissemination. Mol
doi: 10.1101/2022.09.14.507931 Aspects Med. 2018;60:15-26.
13. Coursier D, Calvo F. CAFs vs. TECs: When blood feuds doi: 10.1016/j.mam.2017.11.012
fuel cancer progression, dissemination and therapeutic 25. Maia J, Caja S, Strano Moraes MC, Couto N,
resistance. Cell Oncol (Dordr). 2024;47(4):1091-1112.
Costa-Silva B. Exosome-based cell-cell communication in
doi: 10.1007/s13402-024-00931-z the tumor microenvironment. Front Cell Dev Biol. 2018;6:18.

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