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Tumor Discovery Mg-28-A theoretical novel strategy in cancer therapy

4.6.5. Broad applicability and potential for expanded clinical studies to evaluate its efficacy, pharmacokinetics,
therapeutic horizons and biosafety. Ultimately, Mg-28 therapy could inform the
The fundamental principle of exploiting the increased development of a new paradigm in cancer and infectious
metabolic demands of rapidly dividing cells suggests that disease treatment.
Mg-28 therapy holds promise across a wide spectrum of Despite its promising potential, several challenges
cancer types and stages. In addition, the concept of targeting must be addressed to translate Mg-28 therapy from theory
host cell enzymes essential for pathogen replication opens to practice. The clinical safety and therapeutic efficacy
avenues for exploring its utility in treating other diseases, require extensive, rigorous validation. In addition, Mg-28
such as viral infections—including coronaviruses that rely production is costly and technically complex, and the
on host cell RNA polymerase for replication. Furthermore, clinical trials and regulatory approval processes demand
this approach may be extended to other cofactors, such as significant logistical and financial investments. The short
copper, iron, manganese, zinc, and selenium. half-life of Mg-28 necessitates extremely rapid and efficient
transportation and administration systems to ensure
5. Conclusion and future directions effective delivery.
The Mg-28 method represents a revolutionary and To overcome these challenges and pave the way for
multifaceted approach to cancer therapy, characterized clinical translation, the following strategic actions are
by its dual mechanism of action: The targeted inactivation recommended on duct: (1) Conduct in vitro and in vivo
of crucial Mg-dependent enzymes and highly localized studies to validate the model; (2) establish cancer treatment
intracellular irradiation. centers near nuclear facilities; (3) invest in research and

The intrinsic selectivity of this approach is biologically development of on-site Mg-28 production systems; and
elegant, driven by the elevated Mg demand of rapidly (4) design and implement prioritized transportation
proliferating cancer cells. This phenomenon, quantified networks for timely delivery of Mg-28 to treatment centers.
by the Mg-uptake coefficient, allows for natural tumor
targeting without the need for complex biochemical Acknowledgments
carriers or nanoparticles—thereby enhancing both The authors thank Dr. Vu Thien Y (Pharmaceutical Faculty,
treatment precision and safety. Ton Duc Thang University, Vietnam) for the valuable

Preliminary analytical modeling and LET-dose feedback provided during manuscript preparation.
simulations support the foundational hypothesis, Funding
demonstrating that nanogram-scale doses of Mg-28 can
achieve therapeutic cytotoxic thresholds. Importantly, the None.
behavior of Mg-28 within the tumor microenvironment
embodies a form of natural biological targeting, where cancer Conflict of Interest
cells, fueled by their metabolic and replicative demands, The author declares no competing interests.
act as selective attractors for Mg . This pathway allows
2+
Mg-28 to efficiently infiltrate intracellular compartments, Author contributions
particularly the nucleus and mitochondria, where it disrupts This is a single-authored article.
the enzymatic machinery critical for cancer progression.
Furthermore, the inherent gamma emissions of Mg-28 Ethics approval and consent to participate
confer an integrated self-theranostic capability, enabling Not applicable.
early tumor detection and real-time monitoring of treatment
response, thus offering unparalleled precision in cancer Consent for publication
management. Significantly, this approach holds promise
for application across all cancer types and stages, a distinct Not applicable.
advantage over many existing therapies. Beyond oncology, Availability of data
the principle of targeting host cell enzymes extends to
infectious diseases. For instance, Mg-28 may disrupt the Data are available from the corresponding author upon
replication cycle of viruses—such as coronaviruses—by reasonable request.
inactivating host RNA polymerase, thus offering a novel
antiviral strategy. This innovative approach sets a strong References
foundation for future research and deserves in-depth 1. International Agency for Research on Cancer. Latest Global
exploration through pre-clinical (in vitro and in vivo) and Cancer Data: Cancer Burden Rises to 19.3 Million New Cases

Volume 4 Issue 3 (2025) 79 doi: 10.36922/TD025070010