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Advanced Neurology                                                          EPAC2 null leads to tauopathy



               391-401.                                           https://doi.org/10.1038/ncb1528
               https://doi.org/10.1007/s12035-014-9007-z       32.  Jadhav S, Cubinkova V, Zimova I, et al., 2015, Tau-mediated
                                                                  synaptic damage in Alzheimer’s disease.  Transl Neurosci,
            21.  Greenberg SG, Davies P, 1990, A preparation of Alzheimer   6(1): 214–226.
               paired helical filaments that displays distinct tau proteins by
               polyacrylamide gel electrophoresis. Proc Natl Acad Sci U S A,      https://doi.org/10.1515/tnsci-2015-0023
               87(15): 5827–5831.                              33.  Wang JZ, Grundke-Iqbal I, Iqbal K, 2007, Kinases
               https://doi.org/10.1073/pnas.87.15.5827            and phosphatases and tau sites involved in Alzheimer
                                                                  neurofibrillary degeneration. Eur J Neurosci, 25(1): 59-68.
            22.  Wang JZ, Liu F, 2008, Microtubule-associated protein tau in
               development, degeneration and protection of neurons. Prog      https://doi.org/10.1111/j.1460-9568.2006.05226.x
               Neurobiol, 85(2): 148-175.                      34.  Götz  J, Nitsch RM,  2001,  Compartmentalized tau
               https://doi.org/10.1016/j.pneurobio.2008.03.002    hyperphosphorylation and increased levels of kinases in
                                                                  transgenic mice. Neuroreport, 12(9): 2007–2016.
            23.  Shukla V, Skuntz S, Pant HC, 2012, Deregulated Cdk5
               activity is involved in inducing Alzheimer’s disease.  Arch      https://doi.org/10.1097/00001756-200107030-00045
               Med Res, 43(8): 655–662.                        35.  Liu T, Perry G, Chan HW,  et al., 2004, Amyloid-beta-
               https://doi.org/10.1016/j.arcmed.2012.10.015       induced toxicity of primary neurons is dependent upon
                                                                  differentiation-associated increases in tau and cyclin-
            24.  Novais F, Starkstein S, 2015, Phenomenology of depression   dependent kinase 5 expression.  J  Neurochem, 88(3):
               in Alzheimer’s disease. J Alzheimers Dis, 47(4): 845–855.
                                                                  554–563.
               https://doi.org/10.3233/JAD-148004                 https://doi.org/10.1046/j.1471-4159.2003.02196.x
            25.  Wang  X,  Wang  ZH,  Wu  YY,  et al.,  2013,  Melatonin   36.  Castro-Alvarez JF, Uribe-Arias SA, Mejia-Raigosa D,
               attenuates scopolamine-induced memory/synaptic disorder   et al., 2014, Cyclin-dependent kinase 5, a node protein in
               by rescuing EPACs/miR-124/Egr1 pathway. Mol Neurobiol,   diminished tauopathy: A systems biology approach. Front
               47(1): 373-3781.                                   Aging Neurosci, 6: 232.
               https://doi.org/10.1007/s12035-012-8355-9          https://doi.org/10.3389/fnagi.2014.00232
            26.  Jones KA, Sumiya M, Woolfrey KM,  et al., 2019, Loss of   37.  Lopes JP, Oliveira CR, Agostinho P, 2010, Neurodegeneration
               EPAC2 alters dendritic spine morphology and inhibitory   in an Abeta-induced model of Alzheimer’s disease: The role
               synapse density. Mol Cell Neurosci, 98: 19-31.     of Cdk5. Aging Cell, 9(1): 64-77.
               https://doi.org/10.1016/j.mcn.2019.05.001          https://doi.org/10.1111/j.1474-9726.2009.00536.x
            27.  Yang X, Yao C, Tian T,  et al., 2018, A novel mechanism   38.  Lee MS, Kwon YT, Li M, et al., 2000, Neurotoxicity induces
               of memory loss in Alzheimer’s disease mice via the   cleavage of p35 to p25 by calpain. Nature, 405(6784): 360–364.
               degeneration of entorhinal-CA1 synapses.  Mol Psychiatry,
               23(2): 199-210.                                    https://doi.org/10.1038/35012636
               https://doi.org/10.1038/mp.2016.151             39.  Liu F, Su Y, Li B, et al., 2003, Regulation of amyloid precursor
                                                                  protein (APP) phosphorylation and processing by p35/Cdk5
            28.  Woolfrey KM, Srivastava DP, Photowala H,  et al., 2009,   and p25/Cdk5. FEBS Lett, 547(1-3): 193-196.
               Epac2 induces synapse remodeling and depression and its
               disease-associated forms alter spines. Nat Neurosci, 12(10):      https://doi.org/10.1016/s0014-5793(03)00714-2
               1275–1284.                                      40.  Joshi G, Bekier ME 2 , Wang Y, 2015, Golgi fragmentation
                                                                                  nd
               https://doi.org/10.1038/nn.2386                    in Alzheimer’s disease. Front Neurosci, 9: 340.
            29.  Wu M, Zhang M, Yin X, et al., 2021, The role of pathological      https://doi.org/10.3389/fnins.2015.00340
               tau in synaptic dysfunction in Alzheimer’s diseases. Transl   41.  McBrayer  M,  Nixon  RA,  2013,  Lysosome  and  calcium
               Neurodegener. 10(1): 45.                           dysregulation in Alzheimer’s disease: partners in crime.
               https://doi.org/10.1186/s40035-021-00270-1         Biochem Soc Trans, 41(6): 1495–1502.
            30.  Wang Y, Mandelkow E, 2016, Tau in physiology and      https://doi.org/10.1042/BST20130201
               pathology. Nat Rev Neurosci, 17(1): 5-21.       42.  Ferreira  A,  2012, Calpain dysregulation  in Alzheimer’s
               https://doi.org/10.1038/nrn.2015.1                 disease. ISRN Biochem, 2012: 728571.
                                                                  https://doi.org/10.5402/2012/728571
            31.  Fulga TA, Elson-Schwab I, Khurana V, et al., 2007, Abnormal
               bundling and accumulation of F-actin mediates tau-induced   43.  Camins A, Verdaguer E, Folch J, et al., 2006, involvement
               neuronal degeneration in vivo. Nat Cell Biol, 9(2): 139–148.  of calpain activation in neurodegenerative processes. CNS


            Volume 1 Issue 1 (2022)                         11                        https://doi.org/10.36922/an.v1i1.8
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